Network pharmacology and transcriptomics reveal androgen receptor as a potential protein target for 6PPD-quinone DOI
Xiao-Liang Liao,

Jia-Ming Zhou,

Yujie Wang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 957, P. 177678 - 177678

Published: Nov. 29, 2024

Language: Английский

Potential human health risk of the emerging environmental contaminant 6-PPD quinone DOI
Wan Xin, Geyu Liang, Dayong Wang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175057 - 175057

Published: July 26, 2024

Language: Английский

Citations

20
Exposure to 6-PPD quinone disrupts glucose metabolism associated with lifespan reduction by affecting insulin and AMPK signals in Caenorhabditis elegans DOI
Zhenjun Liu, Yunhui Li, Dayong Wang

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142975 - 142975

Published: July 29, 2024

Language: Английский

Citations

11
Exploring the Fate of 6PPD in Zebrafish (Danio rerio): Understanding Toxicokinetics, Biotransformation Mechanisms, and Metabolomic Profiling at Environmentally Relevant Levels DOI
Chenyang Rao,

Yanxia Zuo,

Dongfang Xiang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137687 - 137687

Published: Feb. 20, 2025

Language: Английский

Citations

1
Characterizing the Metabolism of Tire Rubber-Derived p-Phenylenediamine Quinones to Identify Potential Exposure Biomarkers in Humans DOI
Yingchen Yang, Wei Meng, Ya Zhang

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 5, 2024

There is growing evidence of the frequent detection tire rubber-derived contaminants

Language: Английский

Citations

4
6-PPD quinone at environmentally relevant concentrations induces immunosenescenece by causing immunosuppression during the aging process DOI
Jingwei Wu,

Shao-Ping Shen,

Dayong Wang

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 368, P. 143719 - 143719

Published: Nov. 1, 2024

Language: Английский

Citations

4
Environmental occurrence, fate, human exposure, and human health risks of p-phenylenediamines and their quinones DOI
Ruiying Shi, Zhao Zhang, Aurang Zeb

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 957, P. 177742 - 177742

Published: Nov. 29, 2024

Language: Английский

Citations

3
6PPD, Not 6PPD-Quinone, Induced Serious Zebrafish Eye Damage by Disrupting the Thyroid Signaling Pathway DOI
Jing Chang,

Leisen Zhang,

Juan Zhao

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

N-(1,3-Dimethylbutyl)-N′-phenyl-1,4-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPDQ) showed different acute toxicities bioaccumulation potencies in fish. In this study, we compared the thyroid disrupting effects of 6PPD 6PPDQ through vitro, silico, vivo assays. Interestingly, although similar docking affinities with hormone receptor (TR) isoforms GH3 cell inhibition effects, signaling pathway, eye development, phototactic behaviors, density retinal layer larval zebrafish were significantly affected only following exposure. Further investigation demonstrates that can act as a TR antagonist to reduce opsin protein abundance inhibit cone photoreceptor proliferation, which finally alters structure causes microphthalmus zebrafish. Especially, under environmental relevant concentration exposure, induced alterations trβ, opn1lw1, opn1mw1, rpe65a, nr2e3 gene expressions no significant histopathological change was observed. This study illustrates for first time more serious visual system impairment 6PPDQ, disruption being contributing factor, while other important toxic targets still require further research.

Language: Английский

Citations

3
Effects of Polystyrene Microplastic Exposure on Liver Cell Damage, Oxidative Stress, and Gene Expression in Juvenile Crucian Carp (Carassius auratus) DOI Creative Commons

Xiangtong Li,

Yuequn Huang,

Wenrong Li

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 53 - 53

Published: Jan. 12, 2025

A considerable quantity of microplastic debris exists in the environment and toxicity these materials has a notable impact on aquatic ecosystems. In this paper, 50–500 µm polystyrene microplastics (exposure concentrations were 200 µg/L, 800 3200 µg/L concentrations) selected to study effects (PS-MPs) cell morphology, detoxification enzyme activity, mRNA expression liver tissues crucian carp juveniles. The results demonstrated that: (1) Different PS-MPs cause varying degrees pathological oxidative damage tissue cells carp. higher concentration microplastics, lower antioxidant (CAT, GST, SOD) activity greater damage. These demonstrate typical dose–effect relationship. (2) Principal component analysis Spearman’s correlation that four components, namely glutathione S-transferase (GST) its related genes (GSTpi, GSTα), along with catalase (CAT), contributed most observed outcome. components relatively high level responsiveness PS-MP exposure can be employed as ecotoxicological indicators microplastics. (3) This experiment evaluated five three treatments, which found had different gene tested involved response pathways associated virulence. study, was determined at cellular, protein, levels, combined principal identify sensitivity provide scientific basis for ecological risk assessment safe use

Language: Английский

Citations

0
Aggregate exposure pathways for 6PPD-quinone: A source-to-target site continuum integrating exposure and human health DOI Creative Commons
Edmond Sanganyado

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Comparative effects of 6PPD and 6PPD-Quinone at environmentally relevant concentrations on hepatotoxicity, glucolipid metabolism and ferroptotic response in adult zebrafish DOI
Zhe Wang,

Mingjun Zhu,

Yao Hu

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 275, P. 121386 - 121386

Published: March 12, 2025

Language: Английский

Citations

0