Occurrence, toxicity and ecological risk of Bisphenol A analogues in aquatic environment – A review

Ecotoxicology and Environmental Safety, Год журнала: 2020, Номер 208, С. 111481 - 111481

Опубликована: Окт. 23, 2020

Bisphenol analogues (BPs) have been widely applied to industry as the substitutes for bisphenol A (BPA), which detected frequently in surface water, sediment, sewage and sludge. The presence of BPs natural environment could pose risks aquatic ecosystem human health. This study outlined occurrence, toxicity manifested their potential ecological risk throughout world. As BPA was losing its dominance, while were occupying a large part, especially S (BPS), F (BPF) AF (BPAF). In some heavily polluted areas, concentration reached µg/L environment, effluent plants higher than that water. content sludge sediment more aqueous phase. All other BPS P (BPP) had moderate toxicity. current data supports exposure may adverse effects on dysfunction endocrine system such thyroid hormone concentration, enzyme activity, even cell dysfunction, gene damage chromosomal abnormalities. According quotient (RQ), BPF shows highest China, Japan South Korea, followed by BPS. occurrence bisphenols neurotoxicity organisms merit further investigation.

Язык: Английский

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Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(16), С. 5761 - 5761

Опубликована: Авг. 11, 2020

Bisphenol A (BPA) is an organic synthetic compound serving as a monomer to produce polycarbonate plastic, widely used in the packaging for food and drinks, medical devices, thermal paper, dental materials. BPA can contaminate food, beverage, air, soil. It accumulates several human tissues organs potentially harmful health through different molecular mechanisms. Due its hormone-like properties, may bind estrogen receptors, thereby affecting both body weight tumorigenesis. also affect metabolism cancer progression, by interacting with GPR30, impair male reproductive function, binding androgen receptors. Several transcription factors, including PPARγ, C/EBP, Nrf2, HOX, HAND2, are involved action on fat liver homeostasis, cardiovascular system, cancer. Finally, epigenetic changes, such DNA methylation, histones modification, changes microRNAs expression contribute pathological effects. This review aims provide extensive comprehensive analysis of most recent evidence about potential mechanisms which affects health.

Язык: Английский

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A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives

Toxicology, Год журнала: 2019, Номер 424, С. 152235 - 152235

Опубликована: Июнь 12, 2019

Recent studies report widespread usage or exposure to a variety of chemicals with structural functional similarity bisphenol A (BPA), referred as BPA analogues derivatives. These have been detected in foodstuffs, house dust, environmental samples, human urine blood, and consumer products. Compared BPA, relatively little is known about potential toxicity these compounds. This scoping review aimed summarize the human, animal, mechanistic data for 24 emerging interest research regulatory communities. PubMed was searched from March 1, 2015 January 5, 2019 combined results obtained literature searches conducted through 23, 2015, The National Toxicology Program’s Research Report 4 (NTP RR-04), “Biological Activity Bisphenol (BPA) Structural Analogues Functional Alternatives”. Study details are presented interactive displays using Tableau Public. In total, 5748 records were screened inclusion. One hundred sixty seven included NTP RR-04 175 updated search 2019. there 22, 117, 221 epidemiological, experimental vitro included. most frequently studied S (BPS), F (4,4-BPF), AF (BPAF). Notable changes since include growing body epidemiological vivo zebrafish. Numerous new endpoints also evaluated across all three evidence streams including diabetes, obesity, oxidative stress. However, few addressed such neurodevelopmental outcomes impacts on developing mammary prostate glands, which be susceptible disruption by BPA. Further, remains critical need better information order prioritize studies. Moving forward, researchers should ensure that full dose responses performed main effects support hazard risk characterization efforts. gathered here suggests characterizations expand beyond consider analogues.

Язык: Английский

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Worldwide bottled water occurrence of emerging contaminants: A review of the recent scientific literature

Journal of Hazardous Materials, Год журнала: 2020, Номер 392, С. 122271 - 122271

Опубликована: Фев. 14, 2020

Язык: Английский

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Occurrence, distribution, bioaccumulation, and ecological risk of bisphenol analogues, parabens and their metabolites in the Pearl River Estuary, South China

Ecotoxicology and Environmental Safety, Год журнала: 2019, Номер 180, С. 43 - 52

Опубликована: Май 7, 2019

Язык: Английский

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Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring

Environment International, Год журнала: 2020, Номер 144, С. 105811 - 105811

Опубликована: Авг. 29, 2020

Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to bisphenol A (BPA). Moreover, BPA structural analogues (e.g. BPS, BPF, BPAF), used as replacements, are being increasingly detected in human biological matrices. some of its classified endocrine disruptors suspected contributing adverse health outcomes such altered reproduction neurodevelopment, obesity, metabolic disorders among other developmental chronic impairments. One the aims H2020 European Biomonitoring Initiative (HBM4EU) is implementation effect biomarkers at large scales future HBM a systematic standardized way, order complement data with mechanistically-based early effects. This review aimed identify prioritize existing for BPA, well provide relevant mechanistic outcome pathway (AOP) information cover knowledge gaps better interpret biomarker data. comprehensive literature search was performed PubMed all epidemiologic published last 10 years addressing potential relationship between bisphenols alterations parameters. total 5716 references were screened, out which, 119 full-text articles analyzed tabulated detail. work provides first an overview epigenetics, gene transcription, oxidative stress, reproductive, glucocorticoid thyroid hormones, allergy/immune previously studied. Then, promising related neurodevelopmental reproductive including brain-derived neurotrophic factor (BDNF), kisspeptin (KiSS), expression nuclear receptors prioritized, providing insights based on vitro, animal AOP information. Finally, omics technologies discovery implications risk assessment discussed. To best our knowledge, this effort comprehensively bisphenol-related purposes.

Язык: Английский

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Thyroid Disruption by Bisphenol S Analogues via Thyroid Hormone Receptor β: in Vitro, in Vivo, and Molecular Dynamics Simulation Study

Environmental Science & Technology, Год журнала: 2018, Номер 52(11), С. 6617 - 6625

Опубликована: Май 15, 2018

Bisphenol S (4-hydroxyphenyl sulfone, BPS) is increasingly used as a bisphenol A (BPA) alternative. The global usage of BPS and its analogues (BPSs) resulted in the frequent detection their residues multiple environmental media. We investigated potential endocrine-disrupting effects toward thyroid hormone receptor (TR) β. molecular interaction BPSs TRβ ligand binding domain (LBD) was probed by fluorescence spectroscopy dynamics (MD) simulations. caused static quenching LBD. 100 ns MD simulations revealed that significant changes distance between residue His435 at helix 11(H11) Phe459 H12 comparison to no ligand-bound LBD, indicating relative repositioning H12. recombinant two-hybrid yeast assay showed tetrabromobisphenol (TBBPS) (TBBPA) have potent antagonistic activity TRβ, with an IC10 10.1 21.1 nM, respectively. BPA 312 884 significantly altered expression level mRNA gene zebrafish embryos. TBBPS environmentally relevant concentrations implying are not safe alternatives many BPA-free products. Future health risk assessments for TR disruption other adverse should focus more on structure–activity relationship design benign alternatives.

Язык: Английский

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The occurrence, potential toxicity, and toxicity mechanism of bisphenol S, a substitute of bisphenol A: A critical review of recent progress

Ecotoxicology and Environmental Safety, Год журнала: 2019, Номер 173, С. 192 - 202

Опубликована: Фев. 14, 2019

Язык: Английский

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Endocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPA

Nature Reviews Endocrinology, Год журнала: 2019, Номер 15(6), С. 366 - 374

Опубликована: Март 6, 2019

Язык: Английский

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Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review

Nutrients, Год журнала: 2020, Номер 12(2), С. 532 - 532

Опубликована: Фев. 19, 2020

In recent years, bisphenol analogues such as S (BPS) have come to replace A in food packaging and containers, since (BPA) has been shown leach into water, causing numerous negative health effects. Unfortunately, little or no research was done determine the safety of these BPA-free products before they were marketed public a healthier alternative. The latest studies that some may be even more harmful than original BPA situations. This article used literature survey investigate analogue BPS compare it other with regards increased obesity, metabolic disorders, cancer, reproductive defects; among others. It found works via different pathways does while equivalent obesogenic effects, activating preadipocytes, correlated gestational diabetes, not with. also toxic system hormonally promote certain breast cancers at same rate BPA. Therefore, strong argument made regulate exactly manner

Язык: Английский

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