A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives

Toxicology, Год журнала: 2019, Номер 424, С. 152235 - 152235

Опубликована: Июнь 12, 2019

Recent studies report widespread usage or exposure to a variety of chemicals with structural functional similarity bisphenol A (BPA), referred as BPA analogues derivatives. These have been detected in foodstuffs, house dust, environmental samples, human urine blood, and consumer products. Compared BPA, relatively little is known about potential toxicity these compounds. This scoping review aimed summarize the human, animal, mechanistic data for 24 emerging interest research regulatory communities. PubMed was searched from March 1, 2015 January 5, 2019 combined results obtained literature searches conducted through 23, 2015, The National Toxicology Program’s Research Report 4 (NTP RR-04), “Biological Activity Bisphenol (BPA) Structural Analogues Functional Alternatives”. Study details are presented interactive displays using Tableau Public. In total, 5748 records were screened inclusion. One hundred sixty seven included NTP RR-04 175 updated search 2019. there 22, 117, 221 epidemiological, experimental vitro included. most frequently studied S (BPS), F (4,4-BPF), AF (BPAF). Notable changes since include growing body epidemiological vivo zebrafish. Numerous new endpoints also evaluated across all three evidence streams including diabetes, obesity, oxidative stress. However, few addressed such neurodevelopmental outcomes impacts on developing mammary prostate glands, which be susceptible disruption by BPA. Further, remains critical need better information order prioritize studies. Moving forward, researchers should ensure that full dose responses performed main effects support hazard risk characterization efforts. gathered here suggests characterizations expand beyond consider analogues.

Язык: Английский

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Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae

Aquatic Toxicology, Год журнала: 2018, Номер 203, С. 80 - 87

Опубликована: Авг. 3, 2018

Язык: Английский

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Occurrence, fate and risk assessment of BPA and its substituents in wastewater treatment plant: A review

Environmental Research, Год журнала: 2019, Номер 178, С. 108732 - 108732

Опубликована: Сен. 7, 2019

Язык: Английский

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The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos/larvae

Chemosphere, Год журнала: 2019, Номер 220, С. 811 - 817

Опубликована: Янв. 3, 2019

Язык: Английский

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Bioconcentration and Metabolic Effects of Emerging PFOS Alternatives in Developing Zebrafish

Environmental Science & Technology, Год журнала: 2019, Номер 53(22), С. 13427 - 13439

Опубликована: Окт. 14, 2019

The novel PFOS alternatives, 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and sodium p-perfluorous nonenoxybenzenesulfonate (OBS), are emerging in the Chinese market, but little is known about their ecological risks. In this study, zebrafish embryos were exposed to PFOS, F-53B, OBS evaluate bioconcentration acute metabolic consequences. Per- polyfluoroalkyl substances (PFASs) accumulated larvae order of F-53B > OBS, with factors ranging from 20 357. Exposure not increased energy expenditure, reduced feed intake a concentration-dependent manner expression genes involved pathways at transcriptional translational levels. Molecular docking revealed that binding affinities PFASs glucokinase decreased following order: OBS. Finally, results Point Departure (PoD) indicate end points molecular organismal level most sensitive followed by Collectively, has highest potential strongest metabolism-disrupting effects, Our findings have important implications for assessment early developmental effects alternatives wildlife humans.

Язык: Английский

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Bisphenols and Thyroid Hormone

Endocrinology and Metabolism, Год журнала: 2019, Номер 34(4), С. 340 - 340

Опубликована: Янв. 1, 2019

In recent decades, attention has been directed toward the effects of bisphenol A (BPA) on human health.BPA estrogenic activity and is regarded as a representative endocrine disruptor.In addition, mounting evidence indicates that BPA can disrupt thyroid hormone its action.This review examined epidemiological studies to investigate association between exposure levels, analyzed in vivo vitro experiments identify causal relationship mechanism action.BPA involved action not only receptor antagonist, but also through several other mechanisms.Since use bisphenols than recently increased, we reviewed action.

Язык: Английский

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Prenatal exposure to bisphenol A and its alternatives and child neurodevelopment at 2 years

Journal of Hazardous Materials, Год журнала: 2019, Номер 388, С. 121774 - 121774

Опубликована: Ноя. 28, 2019

Язык: Английский

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Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring

The Science of The Total Environment, Год журнала: 2018, Номер 650, С. 557 - 565

Опубликована: Сен. 3, 2018

Язык: Английский

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Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence

International Journal of Environmental Research and Public Health, Год журнала: 2020, Номер 17(8), С. 2654 - 2654

Опубликована: Апрель 13, 2020

Bisphenols (BPs), and especially bisphenol A (BPA), are known endocrine disruptors (EDCs), capable of interfering with estrogen androgen activities, as well being suspected other health outcomes. Given the crucial role thyroid hormones increasing incidence carcinoma in last few decades, this review analyzes effects BPS on thyroid, considering original research vitro, vivo, humans published from January 2000 to October 2019. Both vitro vivo studies reported ability BPs disrupt function through multiple mechanisms. The antagonism receptors (TRs), which affects TR-mediated transcriptional activity, direct action gene expression at pituitary level, competitive binding transport proteins, induction toxicity several cell lines likely main mechanisms leading dysfunction. In humans, results more contradictory, though some evidence suggests potential risk nodules. standardized methodology toxicological prospective epidemiological individual exposure assessments warranted evaluate pathophysiology resulting damage establish temporal relationship between markers long-term effects.

Язык: Английский

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In Silico Prediction of Human Intravenous Pharmacokinetic Parameters with Improved Accuracy

Journal of Chemical Information and Modeling, Год журнала: 2019, Номер 59(9), С. 3968 - 3980

Опубликована: Авг. 12, 2019

Human pharmacokinetics is of great significance in the selection drug candidates, and silico estimation pharmacokinetic parameters early stage development has become trend research owing to its time- cost-saving advantages. Herein, quantitative structure-property relationship studies were carried out predict four human including volume distribution at steady state (VDss), clearance (CL), terminal half-life (t1/2), fraction unbound plasma (fu), using a data set consisting 1352 drugs. A series regression models built most suitable features selected by Boruta algorithm machine learning methods support vector (SVM), random forest (RF), gradient boosting (GBM), XGBoost (XGB). For VDss, SVM showed best performance with R2test = 0.870 RMSEtest 0.208. other three parameters, RF produced superior prediction accuracy (for CL, 0.875 0.103; for t1/2, 0.832 0.154; fu, 0.818 0.291). Assessed 10-fold cross validation, leave-one-out Y-randomization test applicability domain evaluation, these demonstrated excellent stability predictive ability. Compared published estimation, it was further confirmed that our obtained better ability could be used preclinical candidates.

Язык: Английский

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