Impacts of chronic exposure to sublethal diazepam on behavioral traits of female and male zebrafish (Danio rerio) DOI Creative Commons
Kun Chen, Min Wu, Chen Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 208, P. 111747 - 111747

Published: Dec. 8, 2020

Residues of the psychoactive drug diazepam (DZP) may pose potential risks to fish in aquatic environments, especially by disrupting their behavioral traits. In this study, female and male zebrafish were subjected chronic exposure (21 days) sublethal doses (120 12 µg/L) DZP, aimed compare characteristics responses DZP exposure, investigate possible links between those variations brain γ-aminobutyric acid (GABA) acetylcholinesterase (AChE) levels. Chronic significantly decreased swimming velocity locomotor activity both genders, indicating a typical sedative effect. Compared with males, whose was only for 21 days, females became hypoactive on day 14 (i.e., more sensitive), they developed tolerance effect induced 120 μg/L 21. Exposure disturbed traits related social interactions but not males. Those results indicate that exhibits sex-dependent effects behaviors fish. Moreover, days almost all tested associated courtship when genders put together. Sex-dependent GABA AChE levels due also identified. Significant relationships GABA/AChE some parameters detected females,

Language: Английский

A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives DOI Creative Commons
Katherine E. Pelch, Jessica Wignall,

Alexandra E. Goldstone

et al.

Toxicology, Journal Year: 2019, Volume and Issue: 424, P. 152235 - 152235

Published: June 12, 2019

Recent studies report widespread usage or exposure to a variety of chemicals with structural functional similarity bisphenol A (BPA), referred as BPA analogues derivatives. These have been detected in foodstuffs, house dust, environmental samples, human urine blood, and consumer products. Compared BPA, relatively little is known about potential toxicity these compounds. This scoping review aimed summarize the human, animal, mechanistic data for 24 emerging interest research regulatory communities. PubMed was searched from March 1, 2015 January 5, 2019 combined results obtained literature searches conducted through 23, 2015, The National Toxicology Program’s Research Report 4 (NTP RR-04), “Biological Activity Bisphenol (BPA) Structural Analogues Functional Alternatives”. Study details are presented interactive displays using Tableau Public. In total, 5748 records were screened inclusion. One hundred sixty seven included NTP RR-04 175 updated search 2019. there 22, 117, 221 epidemiological, experimental vitro included. most frequently studied S (BPS), F (4,4-BPF), AF (BPAF). Notable changes since include growing body epidemiological vivo zebrafish. Numerous new endpoints also evaluated across all three evidence streams including diabetes, obesity, oxidative stress. However, few addressed such neurodevelopmental outcomes impacts on developing mammary prostate glands, which be susceptible disruption by BPA. Further, remains critical need better information order prioritize studies. Moving forward, researchers should ensure that full dose responses performed main effects support hazard risk characterization efforts. gathered here suggests characterizations expand beyond consider analogues.

Language: Английский

Citations

219
Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae DOI

Qipeng Shi,

Min Wang,

Fengqiong Shi

et al.

Aquatic Toxicology, Journal Year: 2018, Volume and Issue: 203, P. 80 - 87

Published: Aug. 3, 2018

Language: Английский

Citations

166
Occurrence, fate and risk assessment of BPA and its substituents in wastewater treatment plant: A review DOI
Hu Yu, Qingqing Zhu, Xueting Yan

et al.

Environmental Research, Journal Year: 2019, Volume and Issue: 178, P. 108732 - 108732

Published: Sept. 7, 2019

Language: Английский

Citations

154
The adverse effect of TCIPP and TCEP on neurodevelopment of zebrafish embryos/larvae DOI

Ruiwen Li,

Hengqi Wang,

Chuang Mi

et al.

Chemosphere, Journal Year: 2019, Volume and Issue: 220, P. 811 - 817

Published: Jan. 3, 2019

Language: Английский

Citations

110
Bioconcentration and Metabolic Effects of Emerging PFOS Alternatives in Developing Zebrafish DOI
Wenqing Tu, Rubén Martínez, Laia Navarro‐Martín

et al.

Environmental Science & Technology, Journal Year: 2019, Volume and Issue: 53(22), P. 13427 - 13439

Published: Oct. 14, 2019

The novel PFOS alternatives, 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) and sodium p-perfluorous nonenoxybenzenesulfonate (OBS), are emerging in the Chinese market, but little is known about their ecological risks. In this study, zebrafish embryos were exposed to PFOS, F-53B, OBS evaluate bioconcentration acute metabolic consequences. Per- polyfluoroalkyl substances (PFASs) accumulated larvae order of F-53B > OBS, with factors ranging from 20 357. Exposure not increased energy expenditure, reduced feed intake a concentration-dependent manner expression genes involved pathways at transcriptional translational levels. Molecular docking revealed that binding affinities PFASs glucokinase decreased following order: OBS. Finally, results Point Departure (PoD) indicate end points molecular organismal level most sensitive followed by Collectively, has highest potential strongest metabolism-disrupting effects, Our findings have important implications for assessment early developmental effects alternatives wildlife humans.

Language: Английский

Citations

98
Bisphenols and Thyroid Hormone DOI Creative Commons
Min Joo Kim, Young Joo Park

Endocrinology and Metabolism, Journal Year: 2019, Volume and Issue: 34(4), P. 340 - 340

Published: Jan. 1, 2019

In recent decades, attention has been directed toward the effects of bisphenol A (BPA) on human health.BPA estrogenic activity and is regarded as a representative endocrine disruptor.In addition, mounting evidence indicates that BPA can disrupt thyroid hormone its action.This review examined epidemiological studies to investigate association between exposure levels, analyzed in vivo vitro experiments identify causal relationship mechanism action.BPA involved action not only receptor antagonist, but also through several other mechanisms.Since use bisphenols than recently increased, we reviewed action.

Language: Английский

Citations

98
Prenatal exposure to bisphenol A and its alternatives and child neurodevelopment at 2 years DOI
Yangqian Jiang, Jiufeng Li, Shunqing Xu

et al.

Journal of Hazardous Materials, Journal Year: 2019, Volume and Issue: 388, P. 121774 - 121774

Published: Nov. 28, 2019

Language: Английский

Citations

88
Parental co-exposure to bisphenol A and nano-TiO2 causes thyroid endocrine disruption and developmental neurotoxicity in zebrafish offspring DOI

Yongyong Guo,

Lianguo Chen,

Juan Wu

et al.

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 650, P. 557 - 565

Published: Sept. 3, 2018

Language: Английский

Citations

85
Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence DOI Open Access
Francesca Gorini, Elisa Bustaffa, Alessio Coi

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2020, Volume and Issue: 17(8), P. 2654 - 2654

Published: April 13, 2020

Bisphenols (BPs), and especially bisphenol A (BPA), are known endocrine disruptors (EDCs), capable of interfering with estrogen androgen activities, as well being suspected other health outcomes. Given the crucial role thyroid hormones increasing incidence carcinoma in last few decades, this review analyzes effects BPS on thyroid, considering original research vitro, vivo, humans published from January 2000 to October 2019. Both vitro vivo studies reported ability BPs disrupt function through multiple mechanisms. The antagonism receptors (TRs), which affects TR-mediated transcriptional activity, direct action gene expression at pituitary level, competitive binding transport proteins, induction toxicity several cell lines likely main mechanisms leading dysfunction. In humans, results more contradictory, though some evidence suggests potential risk nodules. standardized methodology toxicological prospective epidemiological individual exposure assessments warranted evaluate pathophysiology resulting damage establish temporal relationship between markers long-term effects.

Language: Английский

Citations

84
In Silico Prediction of Human Intravenous Pharmacokinetic Parameters with Improved Accuracy DOI
Yuchen Wang, Haichun Liu,

Yuanrong Fan

et al.

Journal of Chemical Information and Modeling, Journal Year: 2019, Volume and Issue: 59(9), P. 3968 - 3980

Published: Aug. 12, 2019

Human pharmacokinetics is of great significance in the selection drug candidates, and silico estimation pharmacokinetic parameters early stage development has become trend research owing to its time- cost-saving advantages. Herein, quantitative structure-property relationship studies were carried out predict four human including volume distribution at steady state (VDss), clearance (CL), terminal half-life (t1/2), fraction unbound plasma (fu), using a data set consisting 1352 drugs. A series regression models built most suitable features selected by Boruta algorithm machine learning methods support vector (SVM), random forest (RF), gradient boosting (GBM), XGBoost (XGB). For VDss, SVM showed best performance with R2test = 0.870 RMSEtest 0.208. other three parameters, RF produced superior prediction accuracy (for CL, 0.875 0.103; for t1/2, 0.832 0.154; fu, 0.818 0.291). Assessed 10-fold cross validation, leave-one-out Y-randomization test applicability domain evaluation, these demonstrated excellent stability predictive ability. Compared published estimation, it was further confirmed that our obtained better ability could be used preclinical candidates.

Language: Английский

Citations

78