Transformation products of pharmaceuticals in the environment: Their fate, (eco)toxicity and bioaccumulation potential

The Science of The Total Environment, Год журнала: 2021, Номер 802, С. 149916 - 149916

Опубликована: Авг. 27, 2021

Язык: Английский

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Human impacts and their interactions in the Baltic Sea region

Earth System Dynamics, Год журнала: 2022, Номер 13(1), С. 1 - 80

Опубликована: Янв. 3, 2022

Abstract. Coastal environments, in particular heavily populated semi-enclosed marginal seas and coasts like the Baltic Sea region, are strongly affected by human activities. A multitude of impacts, including climate change, affect different compartments environment, these effects interact with each other. As part Earth Assessment Reports (BEAR), we present an inventory discussion human-induced factors processes affecting environment their interrelations. Some naturally occurring modified activities (i.e. coastal processes, hypoxia, acidification, submarine groundwater discharges, marine ecosystems, non-indigenous species, land use cover), some completely agriculture, aquaculture, fisheries, river regulations, offshore wind farms, shipping, chemical contamination, dumped warfare agents, litter microplastics, tourism, management), they all interrelated to degrees. We a general description analysis state knowledge on Our main insight is that change has overarching, integrating impact other can be interpreted as background effect, which implications for factors. Impacts sphere roughly allocated anthropogenic drivers such food production, energy transport, industry economy. The findings from this available information interactions region largely transferred comparable world.

Язык: Английский

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Organizational Principles of Hyporheic Exchange Flow and Biogeochemical Cycling in River Networks Across Scales

Water Resources Research, Год журнала: 2022, Номер 58(3)

Опубликована: Фев. 11, 2022

Abstract Hyporheic zones increase freshwater ecosystem resilience to hydrological extremes and global environmental change. However, current conceptualizations of hyporheic exchange, residence time distributions, the associated biogeochemical cycling in streambed sediments do not always accurately explain complexity observed streams rivers. Specifically, existing conceptual models insufficiently represent coupled transport reactivity along groundwater surface water flow paths, role autochthonous organic matter functioning, feedbacks between surface‐subsurface ecological processes, both within across spatial temporal scales. While simplified approaches these issues are justifiable necessary for transferability, exclusion important processes from our can lead erroneous conclusions inadequate understanding management interconnected environments. This is particularly true at landscape scale, where organizational principles spatio‐temporal dynamics exchange (HEF) remain largely uncharacterized. article seeks identify most drivers controls HEF based on a comprehensive synthesis findings wide range river systems. We use observations test paradigms models, discussing interactions local‐to‐regional hydrological, geomorphological, zone functioning. improved conceptualization reach catchment scales will inform future research directions watershed strategies.

Язык: Английский

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Metformin Contamination in Global Waters: Biotic and Abiotic Transformation, Byproduct Generation and Toxicity, and Evaluation as a Pharmaceutical Indicator

Environmental Science & Technology, Год журнала: 2022, Номер 56(19), С. 13528 - 13545

Опубликована: Сен. 15, 2022

Metformin is the first-line antidiabetic drug and one of most prescribed medications worldwide. Because its ubiquitous occurrence in global waters demonstrated ecotoxicity, metformin, as with other pharmaceuticals, has become a concerning emerging contaminant. subject to transformation, producing numerous problematic transformation byproducts (TPs). The occurrence, removal, toxicity metformin have been continually reviewed; yet, comprehensive analysis pathways, byproduct generation, associated change adverse effects lacking. In this review, we provide critical overview fate during water treatments natural processes compile 32 organic TPs generated from biotic abiotic pathways. These occur aquatic systems worldwide along metformin. Enhanced several compared through organism tests necessitates development complete mineralization techniques for more attention on TP monitoring. We also assess potential indicate overall contamination pharmaceuticals environments, previously acknowledged ones, found be robust or comparable indicator such pharmaceutical contamination. addition, insightful avenues future research

Язык: Английский

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Occurrence of contaminants of emerging concern and pesticides and relative risk assessment in Tunisian groundwater

The Science of The Total Environment, Год журнала: 2023, Номер 906, С. 167319 - 167319

Опубликована: Сен. 23, 2023

Groundwater is an important source for drinking water supply, agricultural irrigation and industrial uses in the Middle East North Africa region. Due to growing need groundwater use, quality studies on presence of contaminants emerging concern (CECs) pesticides have gained attention. The Wadi El Bey one most polluted areas Tunisia. However, very limited data CECs infiltration into aquifers has been described, comparison industrialized countries where contamination comprehensively addressed. To gain early insight potential contamination, wells northeast Tunisia, area with high population density intensive activity were sampled during two seasons analyzed resolution mass spectrometry approaches: target suspect screening. latter was used screening banned pesticides. A selection 116 which 19 are transformation products (TPs) 20 previously prioritized by screened samples. results showed 69 1 TP at concentrations per well, ranging between 43 7384 ng L-1 7.3 80 L-1, respectively. Tunisian do not differ from those countries. WWTPs considered main pollution, classes detected analgesics, antihypertensives artificial sweeteners especially caffeine, salicylic acid ibuprofen found be ubiquitous. Regarding pesticides, triazines herbicides carbamates insecticides pose highest due their ubiquitous presence, leachability them toxicity. environmental risk assessment (ERA) highlighted that ibuprofen, propoxur may environment, consequently, non-target organisms. This study provides occurrence ERA analysis groundwater.

Язык: Английский

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Emerging organic contaminants in the River Ganga and key tributaries in the middle Gangetic Plain, India: Characterization, distribution & controls

Environmental Pollution, Год журнала: 2023, Номер 327, С. 121626 - 121626

Опубликована: Апрель 11, 2023

The presence and distribution of emerging organic contaminants (EOCs) in freshwater environments is a key issue India globally, particularly due to ecotoxicological potential antimicrobial resistance concerns. Here we have investigated the composition spatial EOCs surface water along ∼500 km segment iconic River Ganges (Ganga) tributaries middle Gangetic Plain Northern India. Using broad screening approach, 11 samples, identified 51 EOCs, comprising pharmaceuticals, agrochemicals, lifestyle industrial chemicals. Whilst majority detected were mixture pharmaceuticals chemicals (and sucralose) occurred at highest concentrations. Ten are priority compounds (e.g. sulfamethoxazole, diuron, atrazine, chlorpyrifos, perfluorooctane sulfonate (PFOS), perfluorobutane sulfonate, thiamethoxam, imidacloprid, clothianidin diclofenac). In almost 50% sulfamethoxazole concentrations exceeded predicted no-effect (PNECs) for ecological toxicity. A significant downstream reduction was observed Ganga between Varanasi (Uttar Pradesh) Begusarai (Bihar), likely reflecting dilution effects associated with three major tributaries, all considerably lower EOC than main channel. Sorption and/or redox controls some clopidol), as well relatively high degree mixing within river. We discuss environmental relevance persistence several parent (notably carbamazepine, metribuzin fipronil) transformation products. Associations other hydrochemical parameters including excitation emission matrix (EEM) fluorescence indicated positive, significant, compound-specific correlations tryptophan-, fulvic- humic-like fluorescence. This study expands baseline characterization Indian contributes an improved understanding sources on large river systems.

Язык: Английский

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Emerging organic contaminants in groundwater under a rapidly developing city (Patna) in northern India dominated by high concentrations of lifestyle chemicals

Environmental Pollution, Год журнала: 2020, Номер 268, С. 115765 - 115765

Опубликована: Окт. 1, 2020

Aquatic pollution from emerging organic contaminants (EOCs) is of key environmental importance in India and globally, particularly due to concerns antimicrobial resistance, ecotoxicity drinking water supply vulnerability. Here, using a broad screening approach, we characterize the composition distribution EOCs groundwater Gangetic Plain around Patna (Bihar), as an exemplar rapidly developing urban area northern India. A total 73 were detected 51 samples, typically at ng.L−1 low μg.L−1 concentrations, relating medical veterinary, agrochemical, industrial lifestyle usage. Concentrations often dominated by chemical artificial sweetener sucralose. Seventeen identified are flagged priority compounds European Commission, World Health Organisation and/or for Animal Health: namely, herbicides diuron atrazine; insecticides imidacloprid, thiamethoxam, clothianidin acetamiprid; surfactant perfluorooctane sulfonate (and related perfluorobutane sulfonate, perfluorohexane perfluorooctanoic acid perfluoropentane sulfonate); medical/veterinary sulfamethoxazole, sulfanilamide, dapson, sulfathiazole, sulfamethazine diclofenac. The spatial varies widely, with concentrations declining depth, consistent strong dominant vertical flow control. Groundwater EOC found peak within ∼10 km distance River Ganges, indicating mainly inputs some local hotspots. heterogeneous relationship between population density likely reflects confounding factors including varying input types controls (e.g. spatial, temporal), wastewater treatment infrastructure abstraction. Strong seasonal agreement was observed. Co-existence limited transformation products associated parent indicate active microbial degradation processes. This study characterizes on across rural transition near Patna, Indian city, contributes wider understanding vulnerability shallow surface-derived contamination similar environments.

Язык: Английский

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Association between Aquatic Micropollutant Dissipation and River Sediment Bacterial Communities

Environmental Science & Technology, Год журнала: 2020, Номер 54(22), С. 14380 - 14392

Опубликована: Окт. 26, 2020

Assessment of micropollutant biodegradation is essential to determine the persistence potentially hazardous chemicals in aquatic ecosystems. We studied dissipation half-lives 10 micropollutants sediment-water incubations (based on OECD 308 standard) with sediment from two European rivers sampled upstream and downstream wastewater treatment plant (WWTP) discharge. Dissipation (DT50s) were highly variable between tested compounds, ranging 1.5 772 days. Sediment one river WWTP showed fastest all after RNA normalization. By characterizing bacteria using 16S rRNA sequences, bacterial community composition a was associated its capacity for dissipating micropollutants. Bacterial amplicon sequence variants genera Ralstonia, Pseudomonas, Hyphomicrobium, Novosphingobium, which are known degraders contaminants, significantly more abundant where fast observed. Our study illuminates limitations standard account variation rates due differences composition. This limitation problematic particularly those compounds DT50s close regulatory criteria. Thus, it consider as source variability assessments.

Язык: Английский

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Impact of long-term irrigation with municipal reclaimed wastewater on the uptake and degradation of organic contaminants in lettuce and leek

The Science of The Total Environment, Год журнала: 2020, Номер 765, С. 142742 - 142742

Опубликована: Окт. 4, 2020

Язык: Английский

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Filling in the Gaps in Metformin Biodegradation: a New Enzyme and a Metabolic Pathway for Guanylurea

Applied and Environmental Microbiology, Год журнала: 2021, Номер 87(11)

Опубликована: Март 22, 2021

The widely prescribed pharmaceutical metformin and its main metabolite, guanylurea, are currently two of the most common contaminants in surface wastewater. Guanylurea often accumulates is poorly, if at all, biodegraded wastewater treatment plants. This study describes Pseudomonas mendocina strain GU, isolated from a municipal plant, using guanylurea as sole nitrogen source. genome was sequenced with 36-fold coverage mined to identify degradation genes. gene encoding enzyme initiating metabolism expressed, purified characterized. hydrolase, newly described enzyme, shown transform one equivalent (each) ammonia guanidine. Guanidine also supports growth Cell yields on limiting concentrations revealed that releases all four atoms. Genes complete metabolic transformation were identified bioinformatically, defining pathway follows: guanidine carboxyguanidine allophanate carbon dioxide. first member isochorismatase-like hydrolase protein family, which includes biuret triuret hydrolase. Although homologs, three enzymes show distinct substrate specificities. Pairwise sequence comparisons use similarity networks allowed fine structure discrimination between homologous provided insights into evolutionary origins hydrolase.IMPORTANCE Metformin for type 2 diabetes now being examined potential benefits COVID-19 patients. People taking drug pass it largely unchanged, subsequently enters has been known be metabolized guanylurea. levels exceed metformin, leading former considered "dead-end" metabolite. water pollutants emerging concern, they persist reach nontarget aquatic life humans, latter remains treated water. present completely degrades sequenced, genes involved separated genomic regions. knowledge advances idea not dead-end product will allow bioinformatic identification relevant plant microbiomes other environments subjected metagenomic sequencing.

Язык: Английский

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