Recent Advancement in the Synthesis of Ir-Based Complexes

ACS Omega, Год журнала: 2023, Номер 8(46), С. 43408 - 43432

Опубликована: Ноя. 6, 2023

Cancer is a devastating disease with over 100 types, including lung and breast cancer. Cisplatin metal-based drugs are limited due to their drug resistance side effects. Iridium-based compounds have emerged as promising candidates unique chemical properties resemblance platinum compounds. The objective of this study investigate the synthesis categorization iridium complexes, particular emphasis on potential use anticancer agents. major focus research examine these complexes relevance field cancer treatment. negligible effects flexibility cyclometalated iridium(III) garnered significant interest. Organometallic half-sandwich Ir(III) notable benefits in review places categorizing according ligand environment, afterward considering density coordination number. This primarily focuses several methods for synthesizing Ir divided into subgroups based denticity. number determines ligands coordinated central atom, which impacts stability reactivity. Understanding crucial designing desired investigating Cyclometalated contain meta-cycle E-M-C order σ bond, were synthesized 1999. These high quantum yields, stock shifts, luminescence qualities, cell permeability, strong photostability. They been biosensing, bioimaging, phosphorescence heavy metal complexes.

Язык: Английский

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Configurationally regulated half-sandwich iridium(III)-ferrocene heteronuclear metal complexes: Potential anticancer agents

Journal of Inorganic Biochemistry, Год журнала: 2023, Номер 249, С. 112393 - 112393

Опубликована: Окт. 4, 2023

Язык: Английский

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Antitumor studies evaluation of triphenylphosphine ruthenium complexes with 5,7-dihalo-substituted-8-quinolinoline targeting mitophagy pathways

Journal of Inorganic Biochemistry, Год журнала: 2023, Номер 248, С. 112361 - 112361

Опубликована: Авг. 25, 2023

Язык: Английский

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A comprehensive survey of cytotoxic active half-sandwich Ir(iii) complexes: structural perspective, and mechanism of action

Dalton Transactions, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Since half-sandwich Ir( iii ) complexes have garnered more attention, this review will focus on the intricate connections between cytotoxicity, cellular uptake efficiency, and their intracellular distribution properties, while taking coordination site atom variation into account.

Язык: Английский

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Cytotoxic Organometallic Iridium(III) Complexes

Molecules, Год журнала: 2025, Номер 30(4), С. 801 - 801

Опубликована: Фев. 9, 2025

Iridium complexes attract a lot of attention as highly promising antitumor agents due to their various structures, which offer the modification physicochemical and biological effects. Compared conventional platinum-based drugs, iridium are commonly thought be more active in tumors, resistant platinum stable air moisture conditions. Chloridoiridium range advantages facilitating rational design, reactivity photochemical activity, leading different cytotoxic profiles, diverse mechanisms action specific intracellular organelles targets. They also known good light-mediated chemotherapeutics, serving bioimaging biosensing agents. The potential photophysical properties chloridoiridium(III) can readily controlled by suitable ligand modifications substitution patterns, providing wide versatile structures. Over years, numerous structural types chloridoiridium have been developed studied for antineoplastic activity. In this review, recent advances cytotoxicity studies compounds summarized. categorized review according number coordinated ligands, type donor atoms, nuclearity complexes, etc., allowing thorough discussion structure-activity relationship.

Язык: Английский

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Recent advances in organic fluorophore-based Schiff base metal complexes: Applications in biomedicine and related fields

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102166 - 102166

Опубликована: Март 1, 2025

Язык: Английский

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Preparation of ferrocene‑iridium(III) acylhydrazone complexes and their anticancer application against A549 cell line

Journal of Inorganic Biochemistry, Год журнала: 2025, Номер unknown, С. 112899 - 112899

Опубликована: Март 1, 2025

Язык: Английский

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Dual inhibition of oxidative phosphorylation and glycolysis to enhance cancer therapy

Bioorganic Chemistry, Год журнала: 2024, Номер 147, С. 107325 - 107325

Опубликована: Апрель 2, 2024

Язык: Английский

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Ferrocene-modified half-sandwich iridium(III) and ruthenium(II) propionylhydrazone complexes and anticancer application

Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 257, С. 112586 - 112586

Опубликована: Май 6, 2024

Язык: Английский

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Development of a Highly In Vivo Efficacious Dual Antitumor and Antiangiogenic Organoiridium Complex as a Potential Anti-Lung Cancer Agent

Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(19), С. 13481 - 13500

Опубликована: Окт. 3, 2023

While the phenomenal clinical success of blockbuster platinum (Pt) drugs is highly encouraging, inherent and acquired resistance dose-limiting side effects severely limit their application. To find a better alternative with translational potential, we synthesized library six organo-IrIII half-sandwich [(η5-CpX)Ir(N∧N)Cl]+-type complexes. In vitro screening identified two lead candidates [(η5-CpXPh)Ir(Ph2Phen)Cl]+ (5, CpXPh = tetramethyl-phenyl-cyclopentadienyl Ph2Phen 4,7-diphenyl-1,10-phenanthroline) [(η5-CpXBiPh)Ir(Ph2Phen)Cl]+ (6, CpXBiPh tetramethyl-biphenyl-cyclopentadienyl) nanomolar IC50 values. Both 5 6 efficiently overcame Pt presented excellent cancer cell selectivity in vitro. Potent antiangiogenic properties were demonstrated zebrafish model. Satisfyingly, its nanoliposome Lipo-6 considerably higher vivo antitumor efficacy as compared to cisplatin, well earlier reported IrIII complexes mice bearing A549 non-small lung xenograft. particular, complex first example this class that exerted dual properties.

Язык: Английский

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