Опубликована: Июль 31, 2024
Cp*Co(III) complexes based on the ligand 1-amidino-2-thiourea (guanylylthiourea) have been synthesized and characterized. The antitumor potential of was evaluated in vitro using HeLa HepG2 cell lines. cytotoxicity assessed, along with their effect production reactive oxygen species (ROS), activation apoptotic pathways, cycle progression. Finally, acute toxicity model organism Caenorhabditis elegans.
Язык: Английский
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Фев. 11, 2024
Abstract Malignant tumours of the digestive system cover a wide range diseases that affect health people to large extent. Angiogenesis is indispensable in development, and metastasis tumours, mainly two ways: occupation or formation. Vessels can provide nutrients, oxygen, growth factors for encourage metastasis, so cancer progression depends on simultaneous angiogenesis. Recently, exosomes have been proven participate angiogenesis tumours. They influence by binding tyrosine kinase receptors (VEGFR)-1, VEGFR-2, VEGFR-3 with different affinities, regulating Yap-VEGF pathway, Akt pathway other signaling pathway. Additionally, are potential therapeutic vectors deliver many types cargoes cells. In this review, we summarize roles highlight clinical application prospects, directly used as targers delivery vehicles, antiangiogenic therapy.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9337 - 9337
Опубликована: Авг. 28, 2024
The search for new antineoplastic agents is imperative, as cancer remains one of the most preeminent causes death worldwide. Since discovery therapeutic potential cisplatin, study metallodrugs in chemotherapy acquired increasing interest. Starting from cisplatin derivatives, such oxaliplatin and carboplatin, last years, different compounds were explored, employing metal centers iron, ruthenium, gold, palladium. Nonetheless, face several drawbacks, low water solubility, rapid clearance, possible side toxicity. Encapsulation has emerged a promising strategy to overcome these issues, providing both improved biocompatibility protection payload degradation biological environment. In this respect, liposomes, which are spherical vesicles characterized by an aqueous core surrounded lipid bilayers, have proven be ideal candidates due their versatility. fact, they can encapsulate hydrophilic hydrophobic drugs, biocompatible, properties tuned improve selective delivery tumour sites exploiting passive active targeting. review, we report recent findings on liposomal formulations metallodrugs, with focus encapsulation techniques obtained results.
Язык: Английский
Процитировано
3
Inorganic Chemistry Frontiers, Год журнала: 2023, Номер 10(22), С. 6711 - 6727
Опубликована: Янв. 1, 2023
A hydrolytically stable oxo-Re( v ) complex presents potent in vitro antitumor activity as a single agent or combination with cisplatin and negligible toxicity zebrafish.
Язык: Английский
Процитировано
7
Dalton Transactions, Год журнала: 2024, Номер 53(36), С. 15205 - 15214
Опубликована: Янв. 1, 2024
A novel lipoformulation was developed by encapsulating cationic (S^C)-cyclometallated gold(III) complex [Au(dppta)(N
Язык: Английский
Процитировано
2
Journal of Inorganic Biochemistry, Год журнала: 2024, Номер 263, С. 112792 - 112792
Опубликована: Ноя. 26, 2024
Язык: Английский
Процитировано
2
Опубликована: Июль 31, 2024
Cp*Co(III) complexes based on the ligand 1-amidino-2-thiourea (guanylylthiourea) have been synthesized and characterized. The antitumor potential of was evaluated in vitro using HeLa HepG2 cell lines. cytotoxicity assessed, along with their effect production reactive oxygen species (ROS), activation apoptotic pathways, cycle progression. Finally, acute toxicity model organism Caenorhabditis elegans.
Язык: Английский
Процитировано
1