Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)–Iridium(III) Imidazole–Phenanthroline Complexes with Aggregation-Induced Emission Properties

Inorganic Chemistry, Год журнала: 2024, Номер 63(31), С. 14641 - 14655

Опубликована: Июль 25, 2024

Organotin(IV) and iridium(III) complexes have shown good application potential in the field of anticancer; however, aggregation-caused quenching (ACQ) effect induced by high concentration or dose has limited research on their targeting anticancer mechanism. Then, a series aggregation-induced emission (AIE)-activated butyltin(IV)–iridium(III) imidazole-phenanthroline were prepared this study. Complexes exhibited significant fluorescence improvement aggregated state because restricted intramolecular rotation (RIR), accompanied an absolute quantum yield up to 29.2% (IrSn9). demonstrated vitro antiproliferative antimigration activity against A549 cells, following lysosomal–mitochondrial apoptotic pathway. Nude mouse models further confirmed that had favorable vivo antitumor comparison cisplatin. Therefore, possess as substitutes for platinum-based drugs.

Язык: Английский

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Cellular Mechanistic Considerations on Cytotoxic Mode of Action of Phosphino Ru(II) and Ir(III) Complexes

European Journal of Inorganic Chemistry, Год журнала: 2023, Номер 26(33)

Опубликована: Сен. 27, 2023

Abstract Two piano‐stool ruthenium(II) complexes Ru(η 6 ‐ p ‐cymene)Cl 2 PPh CH OH ( RuPOH ) and P(p‐OCH 3 Ph) RuMPOH two half‐sandwich iridium(III) Ir( η 5 ‐Cp*)Cl IrPOH IrMPOH have been studied in terms of potential anticancer activity on previously selected cell line (human lung adenocarcinoma). Based experimental results obtained monoculture vitro model mechanistic considerations the possible cellular modes action carried out. ICP‐MS analysis revealed higher uptake for less hydrophobic Ir(III) comparison to corresponding Ru(II) compounds. Cytometric showed a predominance apoptosis over other types death all complexes. The apoptotic pathway was confirmed by decrease mitochondrial membrane activation caspases‐3/9 both It concluded that case intense ROS generation is mainly responsible resulting cytotoxicity. trigger simultaneously at least three different cytotoxic pathways i . e ., depletion potential, caspases‐dependent apoptosis, ROS‐associated oxidation. Thus, it can be assumed final accumulation toxic effects time via parallel highest cytotoxicity exhibited when compared with

Язык: Английский

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Selectively attacking tumor cells of Ru/Ir–arene complexes based on meclofenamic acid via cyclooxygenase-2 inhibition

Dalton Transactions, Год журнала: 2023, Номер 52(20), С. 6922 - 6933

Опубликована: Янв. 1, 2023

Breast cancer (BC) is one of the most common malignant tumors and often accompanied by inflammatory processes. Inflammation an essential component tumor microenvironment, which might influence proliferation metastasis. Herein, three metal-arene complexes MA-bip-Ru, MA-bpy-Ir, MA-bpy-Ru were prepared tethering non-steroidal anti-inflammatory drug meclofenamic acid (MA). Among them, MA-bip-Ru MA-bpy-Ir showed lower cytotoxicity towards cells, but significantly high selectivity MCF-7 cells through autophagic pathway exhibited no toxicity against normal HLF showing potential for selective treatment cells. could also effectively destroy 3D multicellular spheroids, demonstrating its clinical application. Besides, properties superior to MA, notably downregulating expression cyclooxygenase-2 (COX-2) inhibiting secretion prostaglandin E2 in vitro. These findings demonstrated that was capable intervening processes act as a anticancer agent, thus presenting new mechanism action complexes.

Язык: Английский

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Cationic N,S-chelate half-sandwich iridium complexes: synthesis, characterization, anticancer and antiplasmodial activity

Biomaterials Science, Год журнала: 2023, Номер 11(21), С. 7090 - 7098

Опубликована: Янв. 1, 2023

A series of cationic N,S-chelate half-sandwich iridium complexes were prepared, which exhibited good anticancer activity against the MCF-7 and MDA-MB-231 cells. Additionally, these are also efficient in antiplasmodial study.

Язык: Английский

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Chlorido-pentamethylcyclopentadienyl-[2-(2-pyridyl-кN)-ferrocenyl-кC]-iridium(III)

Molbank, Год журнала: 2024, Номер 2024(1), С. M1770 - M1770

Опубликована: Фев. 2, 2024

Treatment of 2-pyridyl-ferrocene wit [Cp*IrCl2]2 in the presence NaOAc produces title compound Cp*ClIr[(C5H3C5H4N-кN,кC)Fe(C5H5)] (2) low yield. A crystal structure determination shows (SpSIr/RpRIr)-2 enantiomeric pair diastereomers.

Язык: Английский

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