The
development
of
light-triggered
ruthenium
(Ru)
nanophotocages
has
revolutionized
conventional
methods
drug
administration,
thereby
facilitating
cancer
therapy
in
a
noninvasive
and
temperate
manner.
Ru
employ
distinct
approach
known
as
photoactivated
chemotherapy
(PACT),
wherein
light-induced
ligand
dissociation
yields
toxic
metal
complex
or
capable
performing
other
functions
such
optically
controlled
protein
degradation
delivery.
Simultaneously,
this
process
is
accompanied
by
the
generation
reactive
oxygen
species
(ROS),
which
serve
an
effective
anticancer
agent
combination
with
PACT
photodynamic
(PDT).
Due
to
its
exceptional
attributes
extended
tissue
penetration,
minimized
damage,
red
light
near-infrared
widely
acknowledged
"phototherapeutic
window"
(650-900
nm).
In
Concept,
we
present
overview
most
recent
advancements
within
phototherapeutic
range.
Diverse
aspects,
including
design
principles,
photocaging
efficacy,
photoactivation
mechanisms,
potential
applications
field
biomedical
chemistry,
are
discussed.
Questions
challenges
regarding
their
synthesis,
characterization,
also
This
Concept
would
foster
further
exploration
into
realm
nanophotocages.
Inorganic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
The
photochemotherapeutic
activity
of
diazido
Pt(
iv
)
complexes
towards
bladder
cancer,
a
common
cancer
with
expensive
treatment,
has
been
tuned
via
modification
trans
N
-heterocyclic
ligands,
to
give
candidate
for
preclinical
development.
Inorganic Chemistry,
Год журнала:
2024,
Номер
63(14), С. 6248 - 6259
Опубликована: Март 27, 2024
The
covalent
modification
of
Ru(II)
polypyridyl
complexes
(RPCs)
with
organic
chromophores
is
a
powerful
strategy
to
obtain
metal-based
photosensitizer
agents
(PSs)
improved
performance
for
application
in
photodynamic
therapy
(PDT).
In
this
respect,
perylene-imides
are
particular
interest
due
their
rich
chemical–physical
repertoire,
and
it
therefore
quite
surprising
that
combination
RPCs
has
been
poorly
considered
so
far.
Herein,
we
report
on
the
photophysical
behavior
two
newly
synthesized
bearing
perylene
monoimide
appendant
(PMI-Ad).
Differently
from
majority
RPCs-perylene-imides
dyads,
these
dissymmetric
tethered
metal
centers
through
single
C–C
bond
3-
or
5-position
1,10-phenanthroline
(Ru-3PMI-Ad
Ru-5PMI-Ad).
Both
compounds
show
excellent
singlet
oxygen
photosensitizing
activity,
quantum
yields
reaching
>90%
case
Ru-3PMI-Ad.
A
combined
spectroscopic
theoretical
analysis,
also
involving
transient
absorption
luminescence
lifetime
measurements,
demonstrates
both
undergo
intersystem
crossing
very
fast
time
scale
(tens
picoseconds)
high
efficiency.
Our
results
further
demonstrate
increased
electron
delocalization
between
center
PMI-Ad
chromophore
observed
Ru-3PMI-Ad
additionally
contributes
increase
by
prolonging
triplet
state.
Journal of Inorganic Biochemistry,
Год журнала:
2024,
Номер
260, С. 112692 - 112692
Опубликована: Авг. 12, 2024
The
overuse
of
antimicrobial
agents
in
medical
and
veterinary
applications
has
led
to
the
development
resistance
some
microorganisms
this
is
now
one
major
concerns
modern
society.
In
context,
use
transition
metal
complexes
with
photoactivatable
properties,
which
can
act
as
drug
delivery
systems
triggered
by
light,
could
become
a
potent
strategy
overcome
problem
resistance.
work
several
Ru
terpyridine
ligands
clotrimazole
fragment,
antimycotic
drug,
were
synthesized.
main
goal
was
explore
potential
photoactivated
activity
antifungal
evaluate
effect
introducing
different
substituents
on
ligand.
capable
delivering
unit
upon
irradiation
visible
light
short
period
time.
influence
photodissociation
rate
explained
means
TD-DFT
calculations.
tested
against
three
yeasts,
selected
based
their
prevalence
fungal
infections.
complex
carboxybenzene
attached
ligand
showed
best
species
under
minimal
inhibitory
concentration
values
0.88
μM
phototoxicity
index
50
achieved.
markedly
higher
than
that
free
clotrimazole,
especially
(141
times
higher).
more
active
yeast
cancer
cell
lines.
Molecules,
Год журнала:
2024,
Номер
29(19), С. 4529 - 4529
Опубликована: Сен. 24, 2024
Naphthylimides
play
a
pivotal
role
as
aromatic
heterocyclic
compounds,
serving
the
foundational
structures
for
numerous
pharmacologically
significant
drugs.
These
drugs
encompass
antibacterial,
antifungal,
anticancer,
antimalarial,
antiviral,
anti-inflammatory,
antithrombotic,
and
antiprotozoal
agents.
The
planar
heteroaromatic
characteristics
of
naphthylimides
grant
them
strong
ability
to
intercalate
into
DNA.
This
intercalation
property
renders
naphthylimide
derivatives
highly
valuable
various
biological
activities.
advantageous
pharmacological
activity
ease
synthesis
associated
with
their
provide
benefits
in
design
development
new
compounds
within
this
class.
Currently,
only
few
such
molecules
are
undergoing
preclinical
clinical
evaluations.
In
paper,
we
have
compiled
literature
on
reported
by
researchers
from
2006
2024.
Our
focus
lies
exploring
activities
analogues
drug
discovery
perspective,
while
examining
structure–activity
relationship
mechanisms
action.
Dalton Transactions,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
work
provides
a
simple
new
strategy
to
design
Ru(
ii
)
polypyridyl-based
photoactivated
chemotherapeutic
agents
via
the
attachment
of
‘uncageable’
anticancer
based
on
serendipitous
crossed
aldol
reaction
in
ligand
periphery.
