Anticancer profile of coumarin 6-based Ir(iii) photocatalysts under normoxia and hypoxia by ROS generation and NADH oxidation
Inorganic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(17), С. 5435 - 5448
Опубликована: Янв. 1, 2024
Coumarin
6
appended
Ir(
iii
)
photocatalysts
exhibited
light
activated
anticancer
effects
against
cancer
cells
via
mitochondrial
depolarization
driven
apoptosis
by
inducing
type-I
(NADH
oxidation)
and
type-II
(ROS
generation)
mechanisms.
Язык: Английский
Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
147(9), С. 7161 - 7181
Опубликована: Фев. 20, 2025
Photocatalytic
cancer
therapy
(PCT)
has
emerged
as
a
cutting-edge
anticancer
mechanism
of
action,
harnessing
light
energy
to
mediate
the
catalytic
oxidation
intracellular
substrates.
PCT
is
significant
current
importance
due
its
potential
address
limitations
conventional
chemotherapy,
particularly
drug
resistance
and
side
effects.
This
approach
offers
noninvasive,
targeted
treatment
option
by
utilizing
metal-based
photocatalysts
induce
redox
metabolic
disorders
within
cells.
The
disrupt
cell
metabolism
converting
NADH/NAD(P)H
NAD+/NAD(P)+
via
photoredox
processes,
altering
NAD+/NADH
or
NAD(P)+/NAD(P)H
ratios,
which
are
crucial
for
cellular
metabolism.
Ir(III),
Ru(II),
Re(I),
Os(II)
demonstrated
promising
efficacy.
Despite
these
developments,
gaps
remain
in
literature
translating
this
new
into
clinical
trials.
Perspective
critically
examines
developments
research
area
provides
future
directions
designing
efficient
PCT.
Язык: Английский
RuIII–Morpholine-Derived Thiosemicarbazone-Based Metallodrugs: Lysosome-Targeted Anticancer Agents
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
The
idea
of
coordinating
biologically
active
ligand
systems
to
metal
centers
exploit
their
synergistic
effects
has
gained
momentum.
Therefore,
in
this
report,
three
RuIII
complexes
1–3
morpholine-derived
thiosemicarbazone
ligands
have
been
prepared
and
characterized
by
spectroscopy
HRMS
along
with
the
structure
2
through
a
single-crystal
X-ray
diffraction
study.
solution
stability
was
tested
using
conventional
techniques
such
as
UV–vis
HRMS.
Further,
anticancer
activity
HT-29
HeLa
cancer
cell
lines.
To
gain
insight
into
mechanism
action,
cytotoxicity,
hydrophobicity,
interaction
DNA
HSA
were
evaluated
different
methods
absorption,
fluorescence,
circular
dichroism
studies.
Along
favorable
biomolecule
interaction,
revealed
potent
selectivity
toward
cells,
which
is
prerequisite
for
generation
an
drug.
According
viability
results,
1
highest
cytotoxicity
among
all
group,
against
both
respectively.
Additionally,
fluorescence-active
ruthenium
selectively
target
lysosomes,
live-cell
imaging.
disrupt
lysosome
membrane
potential
generating
excessive
amount
reactive
oxygen
species,
results
apoptotic
mode
death.
Язык: Английский
Anticancer potential of polypyridyl-based Ir(III)-coumarin 6 conjugates under visible light and dark
Inorganic Chemistry Communications,
Год журнала:
2025,
Номер
unknown, С. 114184 - 114184
Опубликована: Фев. 1, 2025
Язык: Английский
Metalla-Aromatic Oligomers: Efficient Photocatalytic Activation for Phototherapy
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 1, 2025
Monodisperse
oligomers,
positioned
as
intermediates
between
polymers
and
small
molecules,
retain
certain
reactivities
of
molecules
while
simultaneously
displaying
the
initial
aggregation
characteristics
polymers.
This
distinctive
structure
bestows
on
them
with
significant
potential
for
a
wide
range
applications.
In
this
study,
series
carbolong
osmium
oligomers
(Os1-Os4)
corresponding
polymer
were
evaluated
photocatalysts.
It
was
discovered
that
their
molar
absorption
coefficients
reactive
oxygen
species
generation
rose
π-conjugation
length,
peaking
at
polymerization
degree
4.
Moreover,
Os4
facilitates
photocatalytic
oxidation
nicotinamide
adenine
dinucleotide
(NADH)
to
its
oxided
form,
NAD+.
vitro
experiments
demonstrated
had
strongest
phototoxicity
index
in
cells
hypoxic
conditions,
highlighting
efficacy
tumor.
Metabolomic
analyses
indicated
exerted
photocytotoxicity
by
disrupting
purine
metabolism.
These
insights
will
guide
future
design
π-conjugated
metal
advancing
Язык: Английский
The Role of Intraligand Charge Transfer Processes in Iridium(III) Complexes with Morpholine-Decorated 4′-Phenyl-2,2′:6′,2″-terpyridine
Molecules,
Год журнала:
2024,
Номер
29(13), С. 3074 - 3074
Опубликована: Июнь 27, 2024
To
investigate
the
impact
of
electron-donating
morpholinyl
(morph)
group
on
ground-
and
excited-state
properties
two
different
types
Ir(III)
complexes,
[IrCl3(R-C6H4-terpy-κ3N)]
[Ir(R-C6H4-terpy-κ3N)2](PF6)3,
compounds
[IrCl3(morph-C6H4-terpy-κ3N)]
(1A),
4[Ir(morph-C6H4-terpy-κ3N)2](PF6)3
(2A),
[IrCl3(Ph-terpy-κ3N)]
(1B)
[Ir(Ph-terpy-κ3N)2](PF6)3
(2B)
were
obtained.
Their
photophysical
comprehensively
investigated
with
aid
static
time-resolved
spectroscopic
methods
accompanied
by
theoretical
DFT/TD-DFT
calculations.
In
case
bis-terpyridyl
iridium(III)
attachment
induced
dramatic
changes
in
absorption
emission
characteristics,
manifested
appearance
a
new,
very
strong
visible
tailing
up
to
600
nm,
significant
bathochromic
shift
2A
relative
model
chromophore.
The
features
2B
found
originate
from
triplet
excited
states
natures:
intraligand
charge
transfer
(3ILCT)
for
small
admixture
metal-to-ligand
(3IL–3MLCT)
2B.
optical
mono-terpyridyl
complexes
less
significantly
impacted
substituent.
Based
UV–Vis
spectra,
wavelengths
lifetimes
environments,
transient
studies,
calculations,
it
was
demonstrated
that
1A
are
governed
singlet
mixed
MLLCT-ILCT
nature,
dominant
contribution
first
component,
is,
metal-ligand-to-ligand
(MLLCT).
involvement
ILCT
transitions
reflected
an
enhancement
molar
extinction
coefficients
bands
range
350–550
red
its
Язык: Английский
Vitamin B6 appended polypyridyl Co(III) complexes for photo‐triggered antibacterial activity
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Abstract
Three
novel
polypyridyl‐Co(III)‐vitamin
B
6
complexes
viz
.,
[Co(CF
3
‐phtpy)(SBVB
)]Cl
(
Co1
),
[Co(anthracene‐tpy)(SBVB
Co2
[Co(NMe
2
Co3
where
4’‐(4‐(trifluoromethyl)phenyl)‐2,2’:6’,2’’‐terpyridine=CF
‐phtpy,
4’‐(anthracen‐9‐yl)‐2,2’:6’,2’’‐terpyridine=anthracene‐tpy;,
4‐([2,2’:6’,2’’‐terpyridin]‐4’‐yl)‐N,N‐dimethylaniline=NMe
(E)‐5‐(hydroxymethyl)‐4‐(((2‐hydroxyphenyl)imino)methyl)‐2‐methylpyridin‐3‐ol=H
SBVB
were
successfully
developed
for
aPDT
(antibacterial
photodynamic
therapy)
applications.
–
exhibited
an
intense
absorption
band
at
ca
.
435–485
nm,
which
is
attributed
to
ligand‐to‐metal
charge
transfer
and
was
beneficial
antibacterial
therapy.
The
distorted
octahedral
geometry
of
the
with
Co
III
N
4
O
core
evident
from
DFT
study.
visible
light
ability
good
photo‐stability
made
them
photosensitizers
aPDT.
displayed
significant
responses
against
gram‐positive
S.
aureus
)
gram‐negative
E.
coli
bacteria
upon
exposure
(10
J
cm
−2
,
400–700
nm)
showed
MIC
values
between
0.01–0.005
μg
mL
−1
activities
these
due
their
damage
bacterial
cell
membranes
via
ROS
generation.
Overall,
this
study
shows
photo‐triggered
ROS‐mediated
bacteria‐killing
potential
Co(III)
complexes.
Язык: Английский
Recent advances in Rh(III)-based anticancer complexes
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
525, С. 216306 - 216306
Опубликована: Ноя. 22, 2024
Язык: Английский
Aggregation‐Enhanced Photodynamic Activity of Organometallic Ru(II)–Arene Complexes
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
39(1)
Опубликована: Сен. 24, 2024
ABSTRACT
Organometallic
Ru(II)–arene
complexes
have
emerged
as
potential
chemotherapeutic
agents
for
improved
cancer
treatment.
However,
the
application
of
photosensitizers
has
been
rarely
explored.
In
consideration
their
excellent
biological
performance,
herein,
three
1–3
bearing
2,3,8,9,14,15‐hexamethyl‐5,6,11,12,17,18‐hexaazatrinapthalene
(HATN‐Me
6
)
acceptor
ligand
designed
and
investigated
photosensitizers.
Distinctively,
produced
negligible
singlet
oxygen
(
1
O
2
generation
in
DMF.
The
mechanism
investigations
indicated
that
large
change
equilibrium
displacement
between
excited
ground
states
rather
than
narrow
energy
gap
results
increased
vibrational
wave
function
overlap
non‐radiative
decay
rate.
Remarkably,
induced
greatly
enhanced
efficiency
an
aggregated
state
due
to
suppression
process,
implying
electronic
structures
play
essential
role
photochemical
properties
functions
organometallic
complexes.
evaluation
showed
exhibited
potent
photocytotoxicity
against
cells,
highlighting
scaffolds
are
platforms
fabrication
efficient
Язык: Английский
Effect of the Appended Morpholinyl Group on Photophysical Behavior of Mono- and Bis-cyclometalated Terpyridine Iridium(III) Chromophores
Inorganic Chemistry,
Год журнала:
2024,
Номер
64(1), С. 646 - 661
Опубликована: Дек. 26, 2024
This
paper
provides
extensive
studies
of
[IrCl(Ph-py)(morph-C6H4-terpy-κ3N)]PF6
(1A),
[Ir(Ph-py)2(morph-C6H4-terpy-κ2N)]PF6
(2A),
[IrCl(Ph-py)(Ph-terpy-κ3N)]PF6
(1B),
and
[Ir(Ph-py)2(Ph-terpy-κ2N)]PF6
(2B)
designed
to
demonstrate
the
possibility
controlling
photophysical
properties
mono-
bis-cyclometalated
complexes
[IrCl(Ph-py)(R-C6H4-terpy-κ3N)]PF6
[Ir(Ph-py)2(R-C6H4-terpy-κ2N)]PF6
through
a
remote
electron-donating
substituent
introduced
into
4′-position
2,2′:6′,2″-terpyridine
(terpy)
via
phenyl
linker.
The
attachment
morpholinyl
(morph)
group
was
evidenced
induce
dramatic
changes
in
emission
characteristics
monocyclometalated
Ir(III)
systems
with
meridionally
coordinated
R-C6H4-terpy
ligand
(κ3N).
In
solution,
obtained
complex
found
be
rare
example
dual-emissive
systems.
Within
series
bearing
bound
central
ion
bidentate
coordination
mode,
appended
induced
minor
effect
on
maximum,
but
it
an
effective
tool
for
extending
excited-state
lifetime,
further
prolonging
increase
solvent
polarity.
results
this
work
are
high
significance
better
understanding
push–pull
dual-emission
phenomena
Ir-based
luminophores,
as
well
developing
chromophores
prolonged
lifetimes.
Язык: Английский