Journal of Functional Foods,
Год журнала:
2024,
Номер
119, С. 106333 - 106333
Опубликована: Июнь 25, 2024
Insects
are
considered
as
a
potentially
eco-friendly,
highly
nutritious,
and
protein-rich
food
source.
We
evaluated
the
effects
of
Tenebrio
molitor
(Tm)
Protaetia
brevitarsis
seulensis
(Pbs)
extracts
in
mouse
model
D-galactose
(D-Gal)
aging,
focusing
on
impact
insect
neuronal
viability,
blood–brain
barrier
(BBB)
integrity,
gut
health.
D-gal
administration
led
to
cognitive
behavioral
deficits
increased
anxiety
levels.
Tm
Pbs
glutathione,
superoxide
dismutase,
catalase
levels;
protected
neurons
brain,
preventing
BBB
disruption
brain
edema;
prevented
deposition
amyloid-β
plaques
prefrontal
cortex
hippocampus.
Furthermore,
both
epithelial
integrity
mitigated
intestinal
inflammation.
Our
findings
suggest
novel
therapeutic
potential
against
aging-related
changes;
they
can
be
used
functional
foods
aging
process
by
controlling
Foods,
Год журнала:
2022,
Номер
11(15), С. 2361 - 2361
Опубликована: Авг. 6, 2022
Inflammation
is
considered
to
be
a
crucial
factor
in
the
development
of
chronic
diseases,
eight
which
were
listed
among
top
ten
causes
death
worldwide
World
Health
Organization’s
Statistics
2019.
Moreover,
traditional
drugs
for
inflammation
are
often
linked
undesirable
side
effects.
As
gentler
alternatives
anti-inflammatory
drugs,
plant-derived
bioactive
peptides
have
been
shown
effective
interventions
against
various
including
Alzheimer’s
disease,
cardiovascular
disease
and
cancer.
However,
an
adequate
systematic
review
structures
activities
has
lacking.
This
paper
reviews
latest
research
on
(PAPs),
mainly
specific
regulatory
mechanisms
PAPs;
structure–activity
relationships
their
enzymatic
processing
based
relationships.
current
problems
PAPs
discussed,
such
as
shallow
exploration
mechanisms,
solution
determination
difficulty,
low
yield
unknown
vivo
absorption
metabolism
proposed
future
directions.
work
aims
provide
reference
functional
activity
research,
nutritional
food
clinical
applications
PAPs.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2021,
Номер
62(22), С. 6225 - 6237
Опубликована: Март 16, 2021
The
role
of
the
intestinal
flora
in
health
and
disease
has
become
a
research
hotspot.
Compared
with
carbohydrates
fats,
proteins
are
metabolized
primarily
by
microbial
fermentation
intestine.
production
protein
products
metabolites
depends
on
composition,
diversity,
metabolism
gut
microbiota.
Several
products,
including
indoles,
phenols,
polyamines,
hydrogen
sulfide
(H2S),
amines,
carnitine,
toxic.
This
study
analyzes
relationship
between
high-protein
diets
(HPDs),
microbiota,
human
disease.
Long-term
HPDs
increase
risk
diseases,
type
2
diabetes
(T2DM),
obesity,
central
nervous
system
(CNS)
cardiovascular
diseases
(CVD)
producing
toxic
colon,
H2S,
ammonia.
Short-term
have
little
effect
healthy
individuals
under
65
years
old.
However,
meeting
requirements
over
old
using
is
more
challenging.
adverse
effects
athletes
minimal.
Natural
compounds
(plant
extracts,
whose
main
constituents
polysaccharides
polyphenols),
prebiotics,
probiotics,
regular
physical
exercise
improve
dysbiosis
reduce
risk.
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
323, С. 117685 - 117685
Опубликована: Янв. 1, 2024
Placenta
is
a
kind
of
traditional
Chinese
medicine,
known
as
"Ziheche",
which
has
the
function
tonifying
qi
and
blood,
nourishing
liver
kidney.
extract
(PE)
been
used
for
delaying
organismal
aging
treating
various
diseases.
Cow
placenta
rich
natural
resource
with
large
mass.
Its
composition
similar
to
that
human
placenta,
but
it
not
effectively
utilized.
However,
little
about
effect
CPE
on
mice.
Food Innovation and Advances,
Год журнала:
2023,
Номер
2(4), С. 272 - 290
Опубликована: Янв. 1, 2023
Recently,
there
has
been
a
growing
focus
on
researching
ways
to
delay
aging
and
protect
against
age-related
illnesses.
Small
molecular
exogenous
peptides,
sourced
from
dietary
elements
like
animals,
plants,
microorganisms,
have
demonstrated
considerable
potential
in
exerting
anti-aging
effects.
Notably,
natural
food-derived
peptides
exhibited
enhanced
stability,
safety,
absorption
efficiency,
heightened
biological
activity.
These
attributes
position
them
with
greater
for
mitigating
aging-related
disorders
compared
alternative
drugs
or
phytochemicals.
This
review
summarizes
the
origins,
structural
attributes,
isolation
methods
of
properties.
It
also
explores
how
these
external
improve
conditions
such
as
neurodegenerative
diseases,
skin
aging,
metabolic
disorders.
The
underlying
mechanisms
dictating
their
impact
well-conserved
signaling
pathways—encompassing
oxidative
stress,
inflammation,
apoptosis,
collagen
synthesis—are
meticulously
elucidated.
paper
engages
an
insightful
exploration
key
challenges
pivotal
trajectories,
grounded
ongoing
research
endeavors.
As
result,
this
is
poised
offer
authoritative
scientific
guidance
invaluable
support
practical
implementation
realm
applications
within
food,
pharmaceutical,
cosmetic
industries.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(7), С. 6408 - 6408
Опубликована: Март 29, 2023
Previous
study
has
shown
that
propolis
ethanolic
extract
(PEE)
a
protective
effect
on
aging
skeletal
muscle
atrophy.
However,
the
exact
molecular
mechanism
remains
unclear.
This
aimed
to
investigate
of
PEE
D-galactose
(D-gal)-induced
damage
in
mouse
C2C12
cells.
The
results
revealed
increased
viability
senescent
cells,
decreased
number
senescence-associated
β-galactosidase
(SA-β-Gal)-positive
cells
and
promoted
differentiation
resisted
oxidative
stress
caused
by
D-gal
activating
Nrf2/HO-1
signaling
pathway
maintained
ability
inhibited
apoptosis
suppressing
p38
phosphorylation
reducing
p53
expression.
In
summary,
our
findings
reveal
which
protects
D-gal-induced
providing
theoretical
basis
for
development
alleviation
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
71(32), С. 12203 - 12215
Опубликована: Авг. 2, 2023
Selenopeptides
are
promising
candidates
for
intervening
in
neuroinflammation;
however,
the
key
role
of
selenium
(Se)
selenopeptides
remains
poorly
understood.
To
address
this
gap,
we
compared
neuroprotective
effects
selenopeptide
Val-Pro-Arg-Lys-Leu-SeMet
(namely,
Se–P1)
and
its
native
peptide
Val-Pro-Arg-Lys-Leu-Met
P1).
Our
results
demonstrate
that
Se–P1
treatment
exhibits
superior
antioxidant
antineuroinflammatory
PC12
cells
lipopolysaccharide
(LPS)-injured
mice
to
P1.
Moreover,
administration
P1
resulted
a
shift
gut
microbiota
composition.
Notably,
during
LPS-induced
injury,
demonstrated
greater
stability
maintaining
composition
treatment.
Specifically,
may
have
positive
impact
on
dysbiosis
by
modulating
inflammatory-related
bacteria
such
as
enhancing
Lactobacillus
abundance
while
reducing
Lachnospiraceae_NK4A136_group.
Furthermore,
alteration
metabolites
induced
exhibited
significant
correlation
with
microbiota,
subsequently
metabolic
pathways
including
histidine
metabolism,
lysine
degradation,
purine
metabolism.
These
findings
suggest
organic
Se
contributes
bioactivities
mitigating
neuroinflammation
LPS-injured
hold
value
development
potential
preventive
or
therapeutic
strategies
against
neurodegenerative
diseases
introduce
novel
concepts
nutrition
supplementation
recommendations.
Food Frontiers,
Год журнала:
2023,
Номер
4(4), С. 1927 - 1945
Опубликована: Окт. 3, 2023
Abstract
Mangiferin
(MAN)
was
a
natural
bioactive
xanthone
with
remarkable
antioxidative,
anti‐inflammatory,
and
antiapoptotic
effects.
The
purpose
of
this
study
to
determine
the
protective
influence
MAN
on
D‐galactose
(D‐gal)‐induced
aging
cognitive
impairment,
together
its
underlying
molecular
mechanism.
network
pharmacology
docking
analysis
revealed
that
has
potential
binding
aging‐related
oxidative
stress
apoptosis
proteins.
In
D‐gal‐induced
mice,
could
significantly
reduce
histopathological
changes
liver
brain
tissues.
Moreover,
administration
obviously
increased
activities
antioxidant
enzymes
(SOD,
T‐AOC,
GSH‐Px,
CAT)
decreased
levels
AChE
MDA
in
serum,
liver,
or
Additionally,
alleviated
learning
memory
disorders
improved
exploration
ability.
Western
blotting
immunohistochemical
results
regulate
expressions
PI3K/Akt/Nrf2
signaling
pathway‐related
proteins
apoptotic‐related
(Bax,
Bcl‐2,
Caspase‐9)
Therefore,
these
findings
suggested
can
be
used
as
potent
dietary
supplement
functional
foods
for
protection
against
impairments.
