Plant Secondary Metabolites: The Weapons for Biotic Stress Management

Metabolites, Год журнала: 2023, Номер 13(6), С. 716 - 716

Опубликована: Май 31, 2023

The rise in global temperature also favors the multiplication of pests and pathogens, which calls into question food security. Plants have developed special coping mechanisms since they are sessile lack an immune system. These use a variety secondary metabolites as weapons to avoid obstacles, adapt their changing environment, survive less-than-ideal circumstances. Plant include phenolic compounds, alkaloids, glycosides, terpenoids, stored specialized structures such latex, trichomes, resin ducts, etc. Secondary help plants be safe from biotic stressors, either by repelling them or attracting enemies, exerting toxic effects on them. Modern omics technologies enable elucidation structural functional properties these along with biosynthesis. A better understanding enzymatic regulations molecular aids exploitation modern pest management approaches biopesticides integrated management. current review provides overview major plant that play significant roles enhancing stress tolerance. It examines involvement both indirect direct defense mechanisms, well storage within tissues. Additionally, this explores importance metabolomics elucidating significance application metabolic engineering breeding for resistance is discussed, sustainable

Язык: Английский

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Recent advances on biologically active coumarin-based hybrid compounds

Medicinal Chemistry Research, Год журнала: 2023, Номер 32(4), С. 617 - 642

Опубликована: Фев. 9, 2023

Язык: Английский

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The evolutionary trajectories of specialized metabolites towards antiviral defense system in plants

Molecular Horticulture, Год журнала: 2024, Номер 4(1)

Опубликована: Янв. 12, 2024

Abstract Viral infections in plants pose major challenges to agriculture and global food security the twenty-first century. Plants have evolved a diverse range of specialized metabolites (PSMs) for defenses against pathogens. Although, PSMs-mediated plant-microorganism interactions been widely discovered, these are mainly confined plant-bacteria or plant-fungal interactions. PSM-mediated plant-virus interaction, however, is more complicated often due additional involvement virus spreading vectors. Here, we review classes PSMs their emerging roles involved antiviral resistances. In addition, evolutionary scenarios between plant, virus-transmitting vectors presented. These advancements comprehending biochemical language during not only lay foundation understanding potential co-evolution across life kingdoms, but also open gateway fundamental principles biological control strategies beyond. Graphical The putative co-evolutionary triad plant (PSM) mediated viruses insect This dynamic trio depicted through interplay represented by pink green arrows, signifying PSM bidirectional occurring virus, host vector.

Язык: Английский

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3-mercaptocoumarins as potential bioactive candidates: From novel synthesis to comparative analysis

Journal of Molecular Structure, Год журнала: 2024, Номер 1320, С. 139657 - 139657

Опубликована: Авг. 14, 2024

Язык: Английский

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Pesticide Engineering from Natural Vanillin: Recent Advances and a Perspective

Engineering, Год журнала: 2024, Номер unknown

Опубликована: Июль 1, 2024

Pesticide ecological safety continues to be a hot issue. The inherent biosafety and physiological functions of vanillin, widely used natural flavor in food additives, have unlocked numerous applications the medical field, leading plethora pharmaceutically active derivatives commercial drugs. Despite its extensive use pharmaceutical discovery industry, vanillin's potential domain green pesticide development has only recently come light. Significantly, advantages low price make vanillin ideal for research (R&D). In this context, review illuminates on transformation into suite innovative agrochemicals. By delving design, synthesis, action mechanisms, bio-safety these vanillin-derived compounds, we uncover novel pathways sustainable agriculture. Further possible directions exploration substance are also outlined. We believe that story about will serve as source inspiration those seeking derive ideas from substances, particularly realm R&D.

Язык: Английский

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Antifungal Activities of Natural Products and Their Hybrid Molecules

Pharmaceutics, Год журнала: 2023, Номер 15(12), С. 2673 - 2673

Опубликована: Ноя. 25, 2023

The increasing cases of drug resistance and high toxicity associated with the currently used antifungal agents are a worldwide public health concern. There is an urgent need to develop new drugs unique target mechanisms. Plant-based compounds, such as carvacrol, eugenol, coumarin, cinnamaldehyde, curcumin, thymol, etc., have been explored for development promising due their diverse biological activities, lack toxicity, availability. However, researchers around world unable fully utilize potential natural products limitations, poor bioavailability aqueous solubility. hybrid molecules containing synthetic approach overcome these limitations control microbes' capability resistance. Based on advantages compounds improve activity, there different reported synthesized compounds. This paper reviews literature report activities products.

Язык: Английский

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An Overview on the Synthesis of Fused Pyridocoumarins with Biological Interest

Molecules, Год журнала: 2022, Номер 27(21), С. 7256 - 7256

Опубликована: Окт. 26, 2022

Pyridocoumarins are a class of synthetic and naturally occurring organic compounds with interesting biological activities. This review focuses on the strategies for synthesis pyridocoumarins presents properties those compounds. The involves formation pyridine ring, at first, from coumarin derivative, such as aminocoumarins, hydroxycoumarins, or other coumarins. pyranone moiety follows an existing piperidine phenol derivative. For above syntheses, [4 + 2] cycloaddition reactions, multi-component reactions (MCR), well metal-catalyzed useful. present anti-cancer, anti-HIV, antimalarial, analgesic, antidiabetic, antibacterial, antifungal, anti-inflammatory, antioxidant

Язык: Английский

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Development of Sustainable Insecticide Candidates for Protecting Pollinators: Insight into the Bioactivities, Selective Mechanism of Action and QSAR of Natural Coumarin Derivatives against Aphids

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(47), С. 18359 - 18374

Опубликована: Ноя. 15, 2023

Plants employ abundant toxic secondary metabolites to withstand insect attack, while pollinators can tolerate some natural defensive compounds. Coumarins, as promising green alternatives chemical insecticides, possess wide application prospects in the crop protection field. Herein, bioactivities of 30 coumarin derivatives against Aphis gossypii were assessed and revealed that 6-methylcoumarin exhibited potent aphicidal activity aphids but displayed no toxicity honeybees. Additionally, using biochemical, bioinformatic, molecular assays, we confirmed action mode was by inhibiting acetylcholinesterase (AChE). Meanwhile, functional assays difference site, which located Lys585 aphid AChE (equivalent Val548 honeybee AChE), principal reason for being safe pollinators. This site further validated mutagenesis data, uncovered how unique selective over or mammalian AChE. Furthermore, a 2D-QSAR model established, revealing central structural feature H3m, offers guidance future design more work provides sustainable strategy take advantage analogues pest management protecting nontarget

Язык: Английский

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Design, synthesis and bactericidal activity of novel coumarin derivatives containing pyridinium salts

Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 202, С. 105967 - 105967

Опубликована: Май 26, 2024

Язык: Английский

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Recent Advances and Outlook of Benzopyran Derivatives in the Discovery of Agricultural Chemicals

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(22), С. 12300 - 12318

Опубликована: Май 27, 2024

Scaffold structures, new mechanisms of action, and targets present enormous challenges in the discovery novel pesticides. The scaffolds is basis for continuous development modern agrochemicals. Identification a good scaffold such as triazole, carbamate, methoxy acrylate, pyrazolamide, pyrido-pyrimidinone mesoionic, bisamide often leads to series In addition, pesticides with same target, including inhibitors succinate dehydrogenase (SDH), oxysterol-binding-protein, p-hydroxyphenyl pyruvate dioxygenase (HPPD), may have or similar structure. Recent years witnessed significant progress using natural products bridges. recent years, there been increasing reports on application benzopyran compounds pesticides, especially osthole coumarin. A systematic comprehensive review active agricultural chemicals helpful promote discussion compounds. Therefore, this work systematically reviewed research derivatives chemicals, summarized antiviral, herbicidal, antibacterial, fungicidal, insecticidal, nematicidal acaricidal activities compounds, discussed structural–activity relationship mechanism action. some fragments were recommended further optimize chemical structure based reference information.

Язык: Английский

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