p-AAB/MXene as a novel adsorbent and SALDI matrix for highly efficient enrichment and rapid MS detection of emerging environmental organic pollutants in beverages and PM2.5
Journal of Chromatography A,
Год журнала:
2025,
Номер
1745, С. 465759 - 465759
Опубликована: Фев. 8, 2025
Язык: Английский
Discovery of novel 3-phenylhydrazone coumarin derivatives as potential antifungal agents against phytopathogenic fungi
Food Chemistry,
Год журнала:
2025,
Номер
486, С. 144655 - 144655
Опубликована: Май 10, 2025
Язык: Английский
Discovery of Coumarin-7-N/O-Acethydrazide Derivatives as Novel Antifungal and Herbicidal Agents
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 3, 2025
Natural
products
(NPs)
have
attracted
increasing
attention
due
to
their
structural
diversity,
abundance,
and
low
environmental
impact,
making
them
valuable
for
novel
fungicide
development.
In
this
study,
a
series
of
coumarin-7-N/O
acethydrazide
derivatives
were
synthesized
by
incorporating
acetic
acid
moieties
into
the
coumarin
scaffold.
The
in
vitro
antifungal
activities
these
compounds
evaluated
against
six
common
plant
pathogenic
fungi.
Compound
B13
demonstrated
significant
effects,
with
EC50
values
3.24,
1.89,
1.70,
0.36,
4.27,
1.50
μg/mL
Botrytis
cinerea,
Alternaria
solani,
Fusarium
graminearum,
Rhizoctonia
Colletotrichum
orbiculare
alternata,
respectively.
Notably,
activity
R.
solani
was
comparable
commercial
boscalid
(EC50
=
0.31
μg/mL),
while
A.
alternata
significantly
higher
than
that
13.60
2.55
μg/mL,
respectively),
Furthermore,
vivo
assays
protective
efficacy
at
200
(86.9%)
Validamycin
(92.1%).
inhibitory
effects
further
confirmed
through
scanning
electron
microscopy
fluorescence
microscopy.
influence
charge
distribution
compound
on
its
investigated
using
Density
Functional
Theory
(DFT).
Meanwhile,
some
exhibited
herbicidal
four
field
weeds.
These
results
indicate
is
promising
candidate
crop
protection,
exhibiting
high
toxicity.
Язык: Английский
Novel Aminocoumarin‐Based Schiff Bases: High Antifungal Activity in Agriculture
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(12)
Опубликована: Авг. 22, 2024
Abstract
Structural
modification
is
an
effective
way
to
improve
the
antifungal
activity
of
natural
products
and
has
been
widely
used
in
development
novel
fungicides.
In
this
work,
a
series
aminocoumarin‐based
Schiff
bases
were
synthesized
characterized
by
1
H‐NMR,
13
C
NMR
HR‐MS
spectra.
The
vitro
inhibition
all
compounds
was
tested
against
four
phytopathogenic
fungi
(
Alternaria
solani
,
Fusarium
oxysporum
Botrytis
cinerea
alternata
)
using
mycelial
growth
rate
method.
results
showed
that
most
target
exhibited
significant
activities.
particular,
5b
5c
5d
5h
5n
7c
7n
7p
more
than
commercially
available
fungicides,
chlorothalonil
azoxystrobin.
structure‐activity
relationship
revealed
electron‐withdrawing
groups
with
electronegativity
introduced
at
C‐3
position
improving
inhibitory
halogenated
benzaldehydes
would
be
necessary
preparation
bases.
compound
(EC
50
=8.73
μg/mL)
=26.25
much
better
positive
controls
(chlorothalonil
azoxystrobin).
Therefore,
could
serve
as
promising
lead
for
broad‐spectrum
which
useful
applications
agriculture.
Язык: Английский
Fluxomic, Metabolomic, and Transcriptomic Analyses Reveal Metabolic Responses to Phenazine-1-carboxamide Synthesized in Pseudomonas chlororaphis
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(43), С. 23928 - 23936
Опубликована: Окт. 18, 2024
Phenazine-1-carboxamide
(PCN)
has
been
exploited
as
a
successful
biopesticide
due
to
its
broad-spectrum
antifungal
activity.
We
engineered
PCN-overproducing
Pseudomonas
chlororaphis
strain
through
overexpressing
shikimate
pathway
genes
(aroB,
aroQ,
aroE,
and
phzC)
deleting
negative
regulatory
(relA,
fleQ,
pykF).
The
optimized
produced
1.92
g/L
PCN
with
yield
of
0.11
g/g
glycerol,
the
highest
titer
ever
reported
by
using
minimal
media.
To
gain
deeper
insights
into
underlying
network,
final
parental
were
examined
three
distinct
omic
data
sets.
13C-metabolic
flux
analysis
revealed
substantial
reconfiguration
in
strain,
including
activation
EDEMP
cycle,
PP
pathway,
glyoxylate
shunt,
pathway.
Metabolomic
results
indicated
that
central
carbon
was
rerouted
Transcriptomic
identified
global
gene
expression
changes.
This
study
forms
basis
for
further
engineering
strains
achieve
outstanding
performance.
Язык: Английский