Heliyon,
Год журнала:
2024,
Номер
10(12), С. e33072 - e33072
Опубликована: Июнь 1, 2024
High-polarity
iridoids
from
Radix
Scrophulariae
(R.
Scrophulariae)
offer
a
range
of
benefits,
including
anti-inflammatory,
antioxidant,
antitumour,
antibacterial,
antiviral,
and
antiallergic
effects.
Although
previous
studies
have
indicated
the
potential
R.
for
hyperthyroidism
prevention
treatment,
specific
active
compounds
involved
their
mechanisms
action
are
not
fully
understood.
This
study
explored
effects
high-polarity
iridoid
glycosides
on
induced
in
rats
by
levothyroxine
sodium.
The
experimental
design
included
control
group,
model
group
treated
with
glycosides.
Serum
triiodothyronine
(T3)
thyroxine
(T4)
levels
were
quantified
using
an
enzyme-linked
immunosorbent
assay
(ELISA).
Transcriptomic
proteomic
analyses
applied
to
liver
samples
identify
differentially
expressed
genes
proteins.
These
complemented
trend
analysis
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
analysis.
effectiveness
key
factors
was
further
examined
through
molecular
biology
techniques.
ELISA
results
notable
increase
T3
T4
hyperthyroid
rats,
which
significantly
mitigated
treatment
revealed
6
upregulated
downregulated
showing
marked
improvement
following
treatment.
Proteomic
changes
30
50
proteins,
improvements
observed
upon
PI3K-Akt
signalling
pathway
investigated
KEGG
Molecular
methods
verified
upregulation
Spp1,
Thbs1,
PI3K,
Akt
reversed
group.
that
highly
polar
can
modulate
Spp1
gene
Thbs1
protein
via
pathway,
suggesting
therapeutic
benefit
providing
basis
drug
development
targeting
this
condition.
International Journal of Clinical Practice,
Год журнала:
2022,
Номер
2022, С. 1 - 6
Опубликована: Авг. 29, 2022
There
is
an
important
role
for
hepatic
stellate
cells
(HSCs)
in
liver
fibrosis.
As
it
stands,
many
traditional
Chinese
medicine
formulations
can
effectively
improve
fibrosis,
whether
clinically
used
or
animal
studies;
however,
the
efficacy
and
mechanism
of
main
remain
unclear,
including
peach
kernel,
which
contains
numerous
phytochemicals
with
a
wide
range
biological
activities.
The
purpose
this
study
was
to
investigate
kernel's
anti-liver
fibrosis
effects.
In
study,
kernel
extracts
inhibited
lipopolysaccharide
(LPS)
activation
HSC-T6
expression
α-smooth
muscle
actin
connective
tissue
growth
factor
induced
by
LPS
cells.
Furthermore,
signal
transducers
involving
protein
kinase
B
mitogen-activated
kinase,
regulate
downstream
genes
associated
inflammation.
result,
inflammatory
responses
subsequently
LPS-induced
transformation
activated
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(9)
Опубликована: Авг. 15, 2024
Abstract
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
an
alarming
ailment
that
leads
to
severe
damage
and
increases
the
risk
of
serious
health
conditions.
The
prevalence
NAFLD
due
oxidative
stress
could
be
mitigated
by
plant‐derived
antioxidants.
This
study
aims
investigate
effects
syringic
acid
(SA)
on
in
a
high‐fat
diet
(HFD)
rat
model.
Twenty‐four
rats
were
randomly
divided
into
four
groups
(
n
=
6):
normal
control,
HFD,
SA‐administered
positive
control
SA
diet.
Rats
received
diet,
remaining
HFD
for
8
weeks.
(20
mg/kg
b.w.)
was
orally
(gavage)
administered
Lipid
profiles
controlled
against
HFD‐fed
p
<
0.05).
reduced
serum
aspartate
aminotransferase
alanine
levels
70%–190%.
also
suppressed
pro‐inflammatory
cytokines
attenuated
histopathological
immunohistochemical
changes
rats.
reversed
suppressing
malondialdehyde
formation
82%
replenished
nonenzymatic
enzymatic
antioxidant
activities
Gene
expressions
nuclear
factor‐erythroid
2‐related
factor/heme
oxygenase
1
(Nrf2/HO‐1)
elevated
SA‐treated
Ameliorative
induced
prominent
through
reversal
inflammation,
regulated
intrinsic
mechanism
defense
stress,
Nrf2/HO‐1
pathway.
Poultry Science,
Год журнала:
2024,
Номер
103(12), С. 104422 - 104422
Опубликована: Окт. 13, 2024
The
pathogenesis
of
fatty
liver
is
highly
intricate.
role
the
gut-liver
axis
in
development
has
gained
increasing
recognition
recent
years.
This
study
was
conducted
to
explore
bile
acid
signaling
and
gut
barrier
liver.
A
total
100
"Jing
Tint
6"
laying
hens,
56-week-old,
were
used
fed
basal
diets
until
60
weeks
age.
At
end
experiment,
thirty
individuals
selected
based
on
degree
hepatic
steatosis.
hens
with
minimal
steatosis
(<
5
%)
chosen
as
healthy
controls,
while
those
severe
(>
33
classified
group.
Laying
controls
showed
significant
differences
body
weight,
index,
abdominal
fat
ratio,
feed
conversion
ratio
(FCR),
albumin
height,
Haugh
unit,
biochemical
indexes.
results
metabolomics
revealed
a
clear
separation
profiles
between
group
multiple
secondary
acids
decreased
group,
indicating
disordered
metabolism.
Additionally,
mRNA
levels
farnesoid
X
receptor
(FXR)
genes
related
transport
significantly
both
terminal
ileum
Moreover,
exhibited
decreases
ileal
crypt
depth,
number
goblet
cells,
expression
tight
junction-related
proteins,
alongside
increase
permeability.
Collectively,
these
findings
suggest
that
acids,
suppressed
FXR-mediated
signaling,
impaired
intestinal
function
are
potential
factors
promoting
These
insights
indicate
regulating
enhancing
may
become
new
preventive
therapeutic
strategies
for
near
future.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(43), С. 23832 - 23843
Опубликована: Окт. 21, 2024
Essential
oils
(EOs)
are
gaining
importance
as
sustainable
food
antioxidants,
but
kinetic
data
on
peroxyl
radical
trapping
missing.
Thirteen
EOs
from
11
botanical
species
were
studied
in
the
inhibited
autoxidation
of
cumene
by
oxygen-uptake
kinetics.
Juniperus
oxycedrus,
Syzygium
aromaticum,
Thymus
vulgaris,
Thymbra
capitata,
Betula
alba,
Pimenta
racemosa,
and
Satureja
montana,
containing
23–86%
phenolic
components
gas
chromatography/mass
spectrometry
(GC–MS)
analysis,
afforded
inhibition
rate
constants
kinh
order
104
M–1
s–1
at
30
°C
similar
to
reference
butylhydroxytoluene
(2,6-di-tert-butyl-4-methylphenol)
(BHT).
They
matched
or
outperformed
BHT
protection
olive
oil.
The
Daucus
carota
Cedrus
atlantica
with
<1%
phenols
those
Apium
graveolens
Tagetes
minuta
no
phenolics
had
chain-breaking
activity.
Key
carvacrol,
thymol,
eugenol,
dihydroeugenol,
umbelliferone,
conyferyl
alcohol,
o-cresol,
m-cresol,
p-cresol,
4-allylphenol,
2,3-xylenol,
2,4-xylenol,
phenol
range
103–104
and,
along
them,
could
potentially
replace
products.
