Discovery of Bis-5-cyclopropylisoxazole-4-carboxamides as Novel Potential 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors DOI
Dongchen Yang, Yan‐En Wang, Miaomiao Chen

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(13), С. 5136 - 5142

Опубликована: Март 27, 2023

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27; HPPD) represents a potential target for novel herbicide development. To discover the more promising HPPD inhibitor, we designed and synthesized series of bis-5-cyclopropylisoxazole-4-carboxamides with different linkers using multitarget pesticide design strategy. Among them, compounds b9 b10 displayed excellent herbicidal activities versus Digitaria sanguinalis (DS) Amaranthus retroflexus (AR) inhibition about 90% at concentration 100 mg/L in vitro, which was better than that isoxaflutole (IFT). Furthermore, best inhibitory effect DS AR 90 85% g (ai)/ha greenhouse, respectively. The structure-activity relationship study showed flexible linker (6 carbon atoms) is responsible increasing their activity. molecular docking analyses could closely bind to active site thus exhibited effect. Altogether, these results indicated be used as candidates targeting HPPD.

Язык: Английский

Design, Synthesis, and Herbicidal Activity of Pyrazole Amide Derivatives as Potential Transketolase Inhibitors DOI

Shiqi Hu,

Yan‐En Wang, Kai Wang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(7), С. 3334 - 3341

Опубликована: Фев. 12, 2024

The design and synthesis of new herbicidal active compounds based on a target are great significance for the development herbicides. Transketolase (TK) plays key role in Calvin cycle plant photosynthesis has been confirmed as potential candidate to develop discover To obtain with ultraefficient targeting TK, series pyrazole amide derivatives were designed synthesized through structural optimization lead compound 4u TK target. bioassay results showed that 6ba 6bj displayed highly inhibitory effect root inhibition about 90% against Digitaria sanguinalis (DS) 80% Amaranthus retroflexus (AR) Setaria viridis (SV) by small cup method, which was better than positive control mesotrione nicosulfuron. Furthermore, exhibited an excellent (against DS) over SV) at dosage 150 g ingredient/ha foliar spray method. enzyme activity test consistent activities. Also, molecular docking analysis went deep into cavity bound strong interaction, might act TK. Above all, promising herbicide Hence, they could be developed more efficient herbicides further optimization.

Язык: Английский

Процитировано

5
Transcriptomic Profiling of Fusarium pseudograminearum in Response to Carbendazim, Pyraclostrobin, Tebuconazole, and Phenamacril DOI Creative Commons

Yuan Zhang,

Kai He, Xuhao Guo

и другие.

Journal of Fungi, Год журнала: 2023, Номер 9(3), С. 334 - 334

Опубликована: Март 8, 2023

Fusarium pseudograminearum has been identified as a significant pathogen. It causes crown rot (FCR), which occurs in several major wheat-producing areas China. Chemical control is the primary measure with to this disease. In study, transcriptome sequencing (RNA-Seq) was used determine different mechanisms of action four frequently fungicides including carbendazim, pyraclostrobin, tebuconazole, and phenamacril on F. pseudograminearum. brief, 381, 1896, 842, 814 differentially expressed genes (DEGs) were under treatments, respectively. After joint analysis, 67 common DEGs obtained, further functional analysis showed that ABC transported pathway significantly enriched. Moreover, FPSE_04130 (FER6) FPSE_11895 (MDR1), two important multidrug transporter whose expression levels simultaneously increased, mined unambiguously demonstrated effects. addition, Mfuzz clustering WGCNA revealed core are involved critical pathways each treatment groups. Taken together, these may play crucial function pseudograminearum's response stress.

Язык: Английский

Процитировано

9
Design, Synthesis, and Herbicidal Activities of N-(5-(3,5-Methoxyphenyl)-(thiazole-2-yl))phenoxyacetamide Derivatives DOI
Na Liu,

Yuanhui Wan,

Zhendong Bai

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(42), С. 23097 - 23107

Опубликована: Авг. 13, 2024

Thiazole and phenoxyacetic acid are key moieties in many natural synthetic biologically active agents. A series of

Язык: Английский

Процитировано

3
Design, Synthesis, and Biological Evaluation of 2-(Benzylsulfonyl)-5-(2-Methoxypyridin-4-yl)-1,3,4-Oxadiazole Derivatives as Novel Herbicides DOI

Sheng Yan,

Chujian Ma,

Lamei Wu

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Design, Synthesis, and Biological Evaluation of 2-(Benzylsulfonyl)-5-(2-Methoxypyridin-4-yl)-1,3,4-Oxadiazole Derivatives as Novel Herbicides DOI Creative Commons

Sheng Yan,

Chujian Ma,

Lamei Wu

и другие.

Advanced Agrochem, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Investigations into Simplified Analogues of the Herbicidal Natural Product (+)‐Cornexistin DOI Creative Commons

Christian Steinborn,

Aldo Tancredi,

Christoph Habiger

и другие.

Chemistry - A European Journal, Год журнала: 2023, Номер 29(39)

Опубликована: Фев. 20, 2023

Abstract We report the design, synthesis and biological evaluation of simplified analogues herbicidal natural product (+)‐cornexistin. Guided by an X‐Ray co‐crystal structure cornexistin bound to transketolase from Zea mays , we attempted identify key interactions that are necessary for maintain its profile. This resulted in preparation three novel investigating importance substituents located on nine‐membered ring cornexistin. One analogue maintained a good level activity could provide researchers insights how further optimize commercialization future.

Язык: Английский

Процитировано

7
Design, Synthesis, and Herbicidal Activity Study of Novel Pyrazole-Carboxamides as Potential Transketolase Inhibitors DOI
Chengkun Li, Junmin Wang, Haijiao Dong

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 21, 2024

Transketolase (TKL; EC 2.2.1.1) has been identified as a potential new herbicide target. In order to discover highly herbicidal active compounds targeting TKL and improve their structural diversity for lead compounds, series of pyrazole-carboxamides 7a–7v were designed synthesized through optimization pyrazole-containing phenoxy amide compound 4u. Among the 7r possessed excellent efficacy against Digitaria sanguinalis (Ds) Amaranthus retroflexus (Ar) by small cup method (the inhibition about 95%, 100 mg/L) foliar spray over 90%, 150 g ai/ha) in greenhouse, which superior that positive control nicosulfuron. More significantly, displayed good crop selectivity toward both maize wheat even at 375 ai/ha. The studies on mode action (MOA) high including enzyme activity, fluorescent quenching experiments, molecular docking analysis between Setaria viridis (Sv)TKL ligand, suggested acts typical inhibitor, benzothiazole ring is an important motif SvTKL activity. Above all, could be candidate development herbicides with MOA weed field.

Язык: Английский

Процитировано

1
Discovery of Bis-5-cyclopropylisoxazole-4-carboxamides as Novel Potential 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors DOI
Dongchen Yang, Yan‐En Wang, Miaomiao Chen

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(13), С. 5136 - 5142

Опубликована: Март 27, 2023

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27; HPPD) represents a potential target for novel herbicide development. To discover the more promising HPPD inhibitor, we designed and synthesized series of bis-5-cyclopropylisoxazole-4-carboxamides with different linkers using multitarget pesticide design strategy. Among them, compounds b9 b10 displayed excellent herbicidal activities versus Digitaria sanguinalis (DS) Amaranthus retroflexus (AR) inhibition about 90% at concentration 100 mg/L in vitro, which was better than that isoxaflutole (IFT). Furthermore, best inhibitory effect DS AR 90 85% g (ai)/ha greenhouse, respectively. The structure-activity relationship study showed flexible linker (6 carbon atoms) is responsible increasing their activity. molecular docking analyses could closely bind to active site thus exhibited effect. Altogether, these results indicated be used as candidates targeting HPPD.

Язык: Английский

Процитировано

3