Design, Synthesis, and Fungicidal Activity of α-Methylene-γ-Butyrolactone Derivatives Bearing a Diphenyl Ether Moiety DOI
Caiyun Chen, Hong‐Wei He, Dan Xu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

The γ-butyrolactone scaffold, commonly present in natural products and bioactive compounds, has played a crucial role the development of novel pesticides. In this study, series α-methylene-γ-butyrolactone derivatives containing diphenyl ether moiety were designed synthesized using scaffold splicing strategy. Bioassays revealed that several target compounds demonstrated potent fungicidal activities, particularly against Phytophthora capsici Valsa mali. Notably, compound B7 (EC50 = 0.809 mg/L) exhibited highest antioomycete activity P. capsici, outperforming famoxadone 41.0 but being less effective than dimethomorph 0.180 mg/L). Meanwhile, C22 1.47 showed strongest antifungal V. mali, which was higher those 1.80 13.6 vivo experiments confirmed satisfactory protective curative effects better famoxadone. Additionally, found to inhibit sporangia formation, zoospore release, cystospore germination at 10 mg/L. Physiological biochemical studies indicated can induce changes mycelial morphology increase cell membrane permeability, modulate respiratory metabolism. Furthermore, both vitro enzymatic inhibition assays molecular docking analysis suggested primary mechanism action may involve binding complex III on chain. This work provides valuable insights for incorporating as agricultural agents.

Язык: Английский

Frontier Exploration of Synthesis and Biological Activity of Vanillin Derivatives DOI

丽琼 张

Journal of Organic Chemistry Research, Год журнала: 2025, Номер 13(01), С. 13 - 20

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Design, Synthesis, and Herbicidal Activity Study of Novel Pyrazole-Carboxamides as Potential Transketolase Inhibitors DOI
Chengkun Li, Junmin Wang, Haijiao Dong

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 21, 2024

Transketolase (TKL; EC 2.2.1.1) has been identified as a potential new herbicide target. In order to discover highly herbicidal active compounds targeting TKL and improve their structural diversity for lead compounds, series of pyrazole-carboxamides 7a–7v were designed synthesized through optimization pyrazole-containing phenoxy amide compound 4u. Among the 7r possessed excellent efficacy against Digitaria sanguinalis (Ds) Amaranthus retroflexus (Ar) by small cup method (the inhibition about 95%, 100 mg/L) foliar spray over 90%, 150 g ai/ha) in greenhouse, which superior that positive control nicosulfuron. More significantly, displayed good crop selectivity toward both maize wheat even at 375 ai/ha. The studies on mode action (MOA) high including enzyme activity, fluorescent quenching experiments, molecular docking analysis between Setaria viridis (Sv)TKL ligand, suggested acts typical inhibitor, benzothiazole ring is an important motif SvTKL activity. Above all, could be candidate development herbicides with MOA weed field.

Язык: Английский

Процитировано

1
A rapid, efficient microwave-assisted synthesis of novel bis-pyrazole analogues using non-toxic and cost-effective catalyst under green solvent medium DOI

Komati Satish Kumar,

Alice R. Robert,

Adapaka Venkateswara Rao

и другие.

Chemical Data Collections, Год журнала: 2024, Номер unknown, С. 101165 - 101165

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

0
Design, Synthesis, and Fungicidal Activity of α-Methylene-γ-Butyrolactone Derivatives Bearing a Diphenyl Ether Moiety DOI
Caiyun Chen, Hong‐Wei He, Dan Xu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

The γ-butyrolactone scaffold, commonly present in natural products and bioactive compounds, has played a crucial role the development of novel pesticides. In this study, series α-methylene-γ-butyrolactone derivatives containing diphenyl ether moiety were designed synthesized using scaffold splicing strategy. Bioassays revealed that several target compounds demonstrated potent fungicidal activities, particularly against Phytophthora capsici Valsa mali. Notably, compound B7 (EC50 = 0.809 mg/L) exhibited highest antioomycete activity P. capsici, outperforming famoxadone 41.0 but being less effective than dimethomorph 0.180 mg/L). Meanwhile, C22 1.47 showed strongest antifungal V. mali, which was higher those 1.80 13.6 vivo experiments confirmed satisfactory protective curative effects better famoxadone. Additionally, found to inhibit sporangia formation, zoospore release, cystospore germination at 10 mg/L. Physiological biochemical studies indicated can induce changes mycelial morphology increase cell membrane permeability, modulate respiratory metabolism. Furthermore, both vitro enzymatic inhibition assays molecular docking analysis suggested primary mechanism action may involve binding complex III on chain. This work provides valuable insights for incorporating as agricultural agents.

Язык: Английский

Процитировано

0