Anti-obesity and hypolipidemic effects of "Jinhua Xiangyuan" tea infusion in high-fat diet-induced obese rats DOI Creative Commons
Jie Xiao, Zhixiong Chen, Shasha Xiang

и другие.

Beverage Plant Research, Год журнала: 2023, Номер 3(1), С. 0 - 0

Опубликована: Янв. 1, 2023

Jinhua Xiangyuan (JHXY) is a unique type of Chinese tea made from roasted oolong and subsequently fermented by Eurotiumcristatum. In this study, we investigated the potential benefits JHXY on obese rats induced high-sucrose high-fat diet. infusion was administered orally at 1.6 g/kg·bw (HI), 0.8 (MI), 0.4 (LI) per day for10 weeks. Weight gain significantly suppressed without affecting appetite. MI HI groups, led to significant reduction in triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), accompanied an increase high-density (HDL-C) levels. A white adipose tissue (WAT) index brown (BAT) were observed. group, morphology hepatocytes restored. The abundance Bifidobacterium elevated, whereas Desulfovibrio reduced. Correlation analysis revealed that ratio Ruminococcus positively correlated with HDL-C; Christensenellaceae_R7_group negatively TC LDL-C, while Lactobacillus BAT/WAT ratio. lipopolysaccharide biosynthesis pathway predicted be weakened (p<0.05); sulfur relay system attenuated, bacterial toxins augmented (p<0.05). Our research showed has enhance metabolic health maintain intestinal homeostasis. Optimal dosage should focal point future research.

Язык: Английский

Consumption of dietary turmeric promotes fat browning and thermogenesis in association with gut microbiota regulation in high-fat diet-fed mice DOI
Chengcheng Yang, Yao Du, Tong Zhao

и другие.

Food & Function, Год журнала: 2024, Номер 15(15), С. 8153 - 8167

Опубликована: Янв. 1, 2024

This study was designed to verify the anti-obesity effect of dietary turmeric powder (TP) as a traditional cooking spice and its underlying mechanism. The HFD-fed C57BL/6J mice were supplemented with or without TP (8%) for 12 weeks. results indicated that glucolipid metabolism disorder high-fat diet (HFD)-fed significantly ameliorated through supplementation TP. consumption also induced beige-fat development brown adipose tissue (BAT)-derived nonshivering thermogenesis in obese mice. 16S rDNA-based microbiota targeted metabolomics analysis intestinal dysbiosis microbial abnormality caused by HFD, reflected dramatically increasing relative abundance

Язык: Английский

Процитировано

3

Fructo-oligosaccharides Alleviated Ulcerative Colitis via Gut Microbiota-Dependent Tryptophan Metabolism in Association with Aromatic Hydrocarbon Receptor Activation in Mice DOI
Chengcheng Yang, Yao Du,

Qimei Li

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 6, 2024

Fructo-oligosaccharide (FOS) is a typical prebiotic with intestinal health-promoting effects. Here, we explored the anticolitis activity of FOS and clarified underlying mechanisms. Dextran sulfate sodium (DSS)-induced mice were gavaged (400 mg/kg) for 37 days, administration alleviated DSS-induced colitis symptoms. Besides, improved gut microbiota dysbiosis modulated microbiota-controlled tryptophan metabolic pathways. Targeted metabolomic results showed that significantly increased colonic levels indole-3-acetic acid (IAA) indole-3-propionic (IPA) subsequently expressions aromatic hydrocarbon receptors (AhR) in colon further promoted interleukin-22 (IL-22) tight junction proteins mice. These findings first time highlight novel mechanism by alleviating modulating microbial metabolism to promote IAA IPA production triggering AhR/IL-22 axis activation.

Язык: Английский

Процитировано

3

Verrucomicrobia: Akkermansia DOI
Yanli Zhang, Qiqiong Li, Huizi Tan

и другие.

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 347 - 377

Опубликована: Янв. 1, 2025

Процитировано

0

Qimen An Tea with Different Storage Years Exhibits Anti-Obesity Activity and Differently Modulates Gut Microbiota in a Year-Dependent Manner DOI
Yubin Chen, Zhuang Li,

Juan Wang

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106121 - 106121

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Fu brick tea supplementation ameliorates non-alcoholic fatty liver disease and associated endotoxemia via maintaining intestinal homeostasis and remodeling hepatic immune microenvironment DOI

Gaolong Zuo,

Meng-Hua Li,

Xiaoli Guo

и другие.

Food Research International, Год журнала: 2025, Номер unknown, С. 116207 - 116207

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

A novel fermented tea FOFT for obesity resistance and gut health restoration via modulation of the gut-fat-liver axis in HFD-induced obese mice DOI

Yan Ma,

Zhi‐Hong Jiang, Hai Xie

и другие.

Journal of Functional Foods, Год журнала: 2025, Номер 128, С. 106809 - 106809

Опубликована: Апрель 8, 2025

Язык: Английский

Процитировано

0

Structural characterization and alleviative effects of novel polysaccharides from Artemisia sphaerocephala Krasch seed on obese mice by regulating gut microbiota DOI

Xiaoqian Zeng,

Pinglian Yu,

Donglu Li

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143407 - 143407

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Exploring the lipid-lowering effects of cinnamic acid and cinnamaldehyde from the perspective of gut microbiota and metabolites DOI
Xueke Wang, Tianxing Li, Ling Dong

и другие.

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The increasing incidence and associated metabolic complications pose major challenges in the treatment of hyperlipidaemia. Cinnamon is a food medicinal resource with lipid metabolism, but mechanism by which its active components, cinnamic acid (CA) cinnamaldehyde (CM), alleviate hyperlipidaemia remains unclear. Biochemical, pathological, gut microbiota, metabolomic analyses were performed to investigate effects CA CM on HFD-fed mice underlying mechanisms involved. Supplementation reduced body weight, liver, adipose tissue accumulation HFD-induced mice; improved glucose metabolism; decreased inflammation oxidative stress levels, showing superior efficacy. Faecal microbiota transplantation confirmed that therapeutic effect was closely related core bacteria metabolites. Specifically, inhibited growth metabolism-related genera (e.g., Turicibacter Romboutsia) metabolites PC, LysoPCs, prostaglandin E2, arachidonic acid) while promoting beneficial Oscillospiraceae Colidextribacter) linoleic acid, phytosphingosine, stercobilin). Additionally, Spearman's correlation analysis revealed serum hepatic lipids, as well inflammatory factors, positively correlated Erysipelatoclostridium, Turicibacter, Eubacterium fissicatena, Enterorhabdus, cervonoyl ethanolamide, acetoxystachybotrydial acetate, whereas they negatively Lachnospiraceae NK4A136, stercobilin, LysoPE (15:0/0:0), phytosphingosine. In contrast, markers exhibited opposite pattern. conclusion, have potential regulate improve metabolism decrease levels.

Язык: Английский

Процитировано

0

Food-derived polysaccharides and anti-obesity effects through enhancing adipose thermogenesis: structure-activity relationships, mechanisms, and regulation of gut microecology DOI Creative Commons
Zhenyu Wang, Qiyu Xu,

Lijuan Hou

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 22

Опубликована: Май 12, 2025

Polysaccharides represent a crucial and extensively utilized bioactive fraction in natural products, which are employed the treatment of metabolic disorders due to their significant therapeutic potential. Recently, food-derived polysaccharides (FPs) have emerged as substances obesity management, valued for ability activate thermogenic fat. This review discusses correlation between structural features FPs efficacy combating obesity. Moreover, molecular mechanism by regulate fat how intestinal microecology induces activity is elucidated. The anti-obesity effects depend on structure, including weight, composition, linkages, conformation, branching. Furthermore, thermogenesis via multiple mechanisms, AMPK, p38, AKT, PGC-1α-FNDC5/irisin, miRNA signaling pathways. Importantly, gut microbiota, together with its associated metabolites gut-derived hormones, pivotal regulatory control brown FPs. work provides an in-depth examination adipose tissue contributes FPs, shedding light potential preventing informing formulation weight-loss remedies.

Язык: Английский

Процитировано

0

Moringa-Fu brick tea extract attenuated high-fat diet-induced obesity via modulating bile acid metabolism and gut microbiota in rats DOI Creative Commons

Jian Ouyang,

Xiuping Li, Changwei Liu

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 109, С. 105766 - 105766

Опубликована: Сен. 5, 2023

Obesity is regarded to be correlated with disorders of lipid metabolism, bile acid metabolism and dysbiosis the gut microbiota. Moringa-Fu brick tea (MFBT), a functional food, has significant anti-obesity effect. However, effectiveness mechanisms MFBT in preventing obesity require further investigation. Here, our results show that moringa-Fu extract (MFTE) displays effects by reducing high-fat diet-induced weight gain adipose tissue accumulation rats, attenuating visceral adiposity index, oxidative stress inflammation. In addition, MFTE could regulate microbiota diversity, reduce relative abundance microbioa associated salt hydrolase (BSH) activity, such as Blautia, Ruminococcaceae, Coprococcus Roseburia. Moreover, improve expression main rate-limiting enzymes CYP7A1 CYP27A1 process synthesis, downregulate intestinal FXR protein, promote serum level, cholesterol liver. Taken together, these suggested serve food for prevention hyperlipidemia association regulating

Язык: Английский

Процитировано

7