Beverage Plant Research,
Год журнала:
2023,
Номер
3(1), С. 0 - 0
Опубликована: Янв. 1, 2023
Jinhua
Xiangyuan
(JHXY)
is
a
unique
type
of
Chinese
tea
made
from
roasted
oolong
and
subsequently
fermented
by
Eurotiumcristatum.
In
this
study,
we
investigated
the
potential
benefits
JHXY
on
obese
rats
induced
high-sucrose
high-fat
diet.
infusion
was
administered
orally
at
1.6
g/kg·bw
(HI),
0.8
(MI),
0.4
(LI)
per
day
for10
weeks.
Weight
gain
significantly
suppressed
without
affecting
appetite.
MI
HI
groups,
led
to
significant
reduction
in
triglycerides
(TG),
total
cholesterol
(TC),
low-density
lipoprotein
(LDL-C),
accompanied
an
increase
high-density
(HDL-C)
levels.
A
white
adipose
tissue
(WAT)
index
brown
(BAT)
were
observed.
group,
morphology
hepatocytes
restored.
The
abundance
Bifidobacterium
elevated,
whereas
Desulfovibrio
reduced.
Correlation
analysis
revealed
that
ratio
Ruminococcus
positively
correlated
with
HDL-C;
Christensenellaceae_R7_group
negatively
TC
LDL-C,
while
Lactobacillus
BAT/WAT
ratio.
lipopolysaccharide
biosynthesis
pathway
predicted
be
weakened
(p<0.05);
sulfur
relay
system
attenuated,
bacterial
toxins
augmented
(p<0.05).
Our
research
showed
has
enhance
metabolic
health
maintain
intestinal
homeostasis.
Optimal
dosage
should
focal
point
future
research.
Food & Function,
Год журнала:
2024,
Номер
15(15), С. 8153 - 8167
Опубликована: Янв. 1, 2024
This
study
was
designed
to
verify
the
anti-obesity
effect
of
dietary
turmeric
powder
(TP)
as
a
traditional
cooking
spice
and
its
underlying
mechanism.
The
HFD-fed
C57BL/6J
mice
were
supplemented
with
or
without
TP
(8%)
for
12
weeks.
results
indicated
that
glucolipid
metabolism
disorder
high-fat
diet
(HFD)-fed
significantly
ameliorated
through
supplementation
TP.
consumption
also
induced
beige-fat
development
brown
adipose
tissue
(BAT)-derived
nonshivering
thermogenesis
in
obese
mice.
16S
rDNA-based
microbiota
targeted
metabolomics
analysis
intestinal
dysbiosis
microbial
abnormality
caused
by
HFD,
reflected
dramatically
increasing
relative
abundance
The
increasing
incidence
and
associated
metabolic
complications
pose
major
challenges
in
the
treatment
of
hyperlipidaemia.
Cinnamon
is
a
food
medicinal
resource
with
lipid
metabolism,
but
mechanism
by
which
its
active
components,
cinnamic
acid
(CA)
cinnamaldehyde
(CM),
alleviate
hyperlipidaemia
remains
unclear.
Biochemical,
pathological,
gut
microbiota,
metabolomic
analyses
were
performed
to
investigate
effects
CA
CM
on
HFD-fed
mice
underlying
mechanisms
involved.
Supplementation
reduced
body
weight,
liver,
adipose
tissue
accumulation
HFD-induced
mice;
improved
glucose
metabolism;
decreased
inflammation
oxidative
stress
levels,
showing
superior
efficacy.
Faecal
microbiota
transplantation
confirmed
that
therapeutic
effect
was
closely
related
core
bacteria
metabolites.
Specifically,
inhibited
growth
metabolism-related
genera
(e.g.,
Turicibacter
Romboutsia)
metabolites
PC,
LysoPCs,
prostaglandin
E2,
arachidonic
acid)
while
promoting
beneficial
Oscillospiraceae
Colidextribacter)
linoleic
acid,
phytosphingosine,
stercobilin).
Additionally,
Spearman's
correlation
analysis
revealed
serum
hepatic
lipids,
as
well
inflammatory
factors,
positively
correlated
Erysipelatoclostridium,
Turicibacter,
Eubacterium
fissicatena,
Enterorhabdus,
cervonoyl
ethanolamide,
acetoxystachybotrydial
acetate,
whereas
they
negatively
Lachnospiraceae
NK4A136,
stercobilin,
LysoPE
(15:0/0:0),
phytosphingosine.
In
contrast,
markers
exhibited
opposite
pattern.
conclusion,
have
potential
regulate
improve
metabolism
decrease
levels.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 22
Опубликована: Май 12, 2025
Polysaccharides
represent
a
crucial
and
extensively
utilized
bioactive
fraction
in
natural
products,
which
are
employed
the
treatment
of
metabolic
disorders
due
to
their
significant
therapeutic
potential.
Recently,
food-derived
polysaccharides
(FPs)
have
emerged
as
substances
obesity
management,
valued
for
ability
activate
thermogenic
fat.
This
review
discusses
correlation
between
structural
features
FPs
efficacy
combating
obesity.
Moreover,
molecular
mechanism
by
regulate
fat
how
intestinal
microecology
induces
activity
is
elucidated.
The
anti-obesity
effects
depend
on
structure,
including
weight,
composition,
linkages,
conformation,
branching.
Furthermore,
thermogenesis
via
multiple
mechanisms,
AMPK,
p38,
AKT,
PGC-1α-FNDC5/irisin,
miRNA
signaling
pathways.
Importantly,
gut
microbiota,
together
with
its
associated
metabolites
gut-derived
hormones,
pivotal
regulatory
control
brown
FPs.
work
provides
an
in-depth
examination
adipose
tissue
contributes
FPs,
shedding
light
potential
preventing
informing
formulation
weight-loss
remedies.
Journal of Functional Foods,
Год журнала:
2023,
Номер
109, С. 105766 - 105766
Опубликована: Сен. 5, 2023
Obesity
is
regarded
to
be
correlated
with
disorders
of
lipid
metabolism,
bile
acid
metabolism
and
dysbiosis
the
gut
microbiota.
Moringa-Fu
brick
tea
(MFBT),
a
functional
food,
has
significant
anti-obesity
effect.
However,
effectiveness
mechanisms
MFBT
in
preventing
obesity
require
further
investigation.
Here,
our
results
show
that
moringa-Fu
extract
(MFTE)
displays
effects
by
reducing
high-fat
diet-induced
weight
gain
adipose
tissue
accumulation
rats,
attenuating
visceral
adiposity
index,
oxidative
stress
inflammation.
In
addition,
MFTE
could
regulate
microbiota
diversity,
reduce
relative
abundance
microbioa
associated
salt
hydrolase
(BSH)
activity,
such
as
Blautia,
Ruminococcaceae,
Coprococcus
Roseburia.
Moreover,
improve
expression
main
rate-limiting
enzymes
CYP7A1
CYP27A1
process
synthesis,
downregulate
intestinal
FXR
protein,
promote
serum
level,
cholesterol
liver.
Taken
together,
these
suggested
serve
food
for
prevention
hyperlipidemia
association
regulating
