Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
290, С. 117811 - 117811
Опубликована: Янв. 1, 2025
Di
(2-ethylhexyl)
phthalate
(DEHP)
is
widespread
in
the
environment.
It
can
impair
sperm
function
through
damaging
development
process.
However,
few
studies
have
focused
on
tail
that
directly
related
to
motility.
In
this
study,
we
demonstrate
DEHP
impedes
conversion
of
riboflavin
mitochondrial
sheath
midsection
tail,
resulting
reduced
ATP
(adenosine
triphosphate)
synthesis,
thereby
inhibiting
The
results
HPLC-MS/MS
showed
metabolites
were
transported
testes
and
epididium,
indicating
MEHP
(Mono-2-ethylexyl
phthalate)
could
affect
espermatozoa
mature.
Sperm
motility
analysis
determined
decreased
with
increasing
concentration.
movement
mainly
dependent
motility,
which
largely
by
structure
energy
supply.
Electron
microscopy
images
illustrate
there
are
no
observable
changes
basic
kinematic
tail.
causes
a
decrease
complex
II
activity
respiratory
chain
interfering
synthesis
cofactor
FAD
(Flavin
adenine
dinucleotide),
leads
Therefore,
exposure
reduce
decreasing
This
study
exemplifies
importance
dysfunction
caused
environmental
pollutants.
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 579 - 579
Опубликована: Май 8, 2024
Microplastics
(MPs)
are
plastic
particles
between
0.1
and
5000
µm
in
size
that
have
attracted
considerable
attention
from
the
scientific
community
general
public,
as
they
threaten
environment.
contribute
to
various
harmful
effects,
including
lipid
peroxidation,
DNA
damage,
activation
of
mitogen-activated
protein
kinase
pathways,
cell
membrane
breakages,
mitochondrial
dysfunction,
lysosomal
defects,
inflammation,
apoptosis.
They
affect
cells,
tissues,
organs,
overall
health,
potentially
contributing
conditions
like
cancer
cardiovascular
disease.
pose
a
significant
danger
due
their
widespread
occurrence
food.
In
recent
years,
information
has
emerged
indicating
MPs
can
cause
oxidative
stress
(OS),
known
factor
accelerating
aging
organisms.
This
comprehensive
evaluation
exposed
notable
variability
reported
connection
OS.
work
aims
provide
critical
review
whether
harmfulness
constitute
environmental
contaminants
may
result
OS
through
analysis
research
existing
literature,
well
an
assessment
characteristics
causing
Additionally,
article
covers
analytical
methodology
used
this
field.
The
conclusions
point
necessity
for
further
into
effects
on
Metabolites,
Год журнала:
2022,
Номер
12(10), С. 897 - 897
Опубликована: Сен. 23, 2022
Mitochondria
are
highly
dynamic
cellular
organelles
that
perform
crucial
functions
such
as
respiration,
energy
production,
metabolism,
and
cell
fate
decisions.
Mitochondrial
damage
dysfunction
critically
lead
to
the
pathogenesis
of
various
diseases
including
cancer,
diabetes,
neurodegenerative
cardiovascular
disorders.
in
response
environmental
contaminant
exposure
its
association
with
has
also
been
reported.
Recently,
persistent
pollutants,
micro-
nanoplastics,
have
become
growing
global
threats
potential
health
risks.
In
this
review,
we
discuss
impact
nanoplastics
on
mitochondria
review
current
knowledge
field.
