Maackiain induces apoptosis and autophagy via ROS-mediated endoplasmic reticulum stress in endometrial cancer

International Immunopharmacology, Год журнала: 2025, Номер 147, С. 113935 - 113935

Опубликована: Янв. 5, 2025

Язык: Английский

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Mulberrin suppresses gastric cancer progression and enhances chemosensitivity to oxaliplatin through HSP90AA1/PI3K/AKT axis

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156441 - 156441

Опубликована: Янв. 1, 2025

Язык: Английский

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Cathepsin-K Targeted by Sanggenol L Induces Lethal Autophagy through ROS-Dependent AMPK/mTOR Signaling in Gastric Cancer

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2025, Номер unknown, С. 100611 - 100611

Опубликована: Апрель 1, 2025

Язык: Английский

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Moracin D suppresses cell growth and induces apoptosis via targeting the XIAP/PARP1 axis in pancreatic cancer

Phytomedicine, Год журнала: 2024, Номер 128, С. 155527 - 155527

Опубликована: Март 11, 2024

Язык: Английский

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Gastrointestinal Cancer Therapeutics via Triggering Unfolded Protein Response and Endoplasmic Reticulum Stress by 2-Arylbenzofuran

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 999 - 999

Опубликована: Янв. 13, 2024

Gastrointestinal cancers are a major global health challenge, with high mortality rates. This study investigated the anti-cancer activities of 30 monomers extracted from Morus alba L. (mulberry) against gastrointestinal cancers. Toxicological assessments revealed that most compounds, particularly immunotoxicity, exhibit some level toxicity, but it is generally not life-threatening under normal conditions. Among these components, Sanggenol L, Sanggenon C, Kuwanon H, 3′-Geranyl-3-prenyl-5,7,2′,4′-tetrahydroxyflavone, Morusinol, Mulberrin, Moracin P, E, and A demonstrate significant properties various cancers, including colon, pancreatic, gastric The mechanism chemical components was explored in cancer cells, revealing they inhibit cell cycle DNA replication-related gene expression, leading to effective suppression tumor growth. Additionally, induced unfolded protein response (UPR) endoplasmic reticulum (ER) stress, potentially resulting damage, autophagy, death. an active monomer characterized as 2-arylbenzofuran, found induce ER stress promote apoptosis confirming its potential growth vitro vivo. These findings highlight therapeutic especially focusing on P potent inducer apoptosis.

Язык: Английский

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Innate Immune Cells in Melanoma: Implications for Immunotherapy

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8523 - 8523

Опубликована: Авг. 5, 2024

The innate immune system, composed of neutrophils, basophils, eosinophils, myeloid-derived suppressor cells (MDSCs), macrophages, dendritic (DCs), mast (MCs), and lymphoid (ILCs), is the first line defense. Growing evidence demonstrates crucial role immunity in tumor initiation progression. Several studies support idea that immunity, through release pro- and/or anti-inflammatory cytokines growth factors, plays a significant pathogenesis, progression, prognosis cutaneous malignant melanoma (MM). Cutaneous most common skin cancer, with an incidence rapidly increased recent decades. Melanoma highly immunogenic tumor, due to its high mutational burden. metastatic form retains mortality. advent immunotherapy revolutionized therapeutic approach this significantly ameliorated patients' clinical outcome. In review, we will recapitulate multiple roles related implications for immunotherapy.

Язык: Английский

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Cell Death Modalities in Therapy of Melanoma

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3475 - 3475

Опубликована: Апрель 8, 2025

Melanoma, one of the most lethal cancers, demands urgent and effective treatment strategies. However, a successful therapeutic approach requires precise understanding mechanisms underlying melanoma initiation progression. This review provides an overview pathogenesis, identifies current pathogenic factors contributing to mortality, explores targeted therapy checkpoint inhibitor therapy. Furthermore, we examine classification corresponding therapies, along with advancements in various cell death for treatment. We also discuss status some drawbacks encountered during research stages such as resistance metastasis.

Язык: Английский

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Research Progress of Traditional Chinese Medicine in the Treatment of Gastric Cancer Based on Different Signaling Pathways

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(04), С. 2136 - 2143

Опубликована: Янв. 1, 2025

Язык: Английский

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Mori Folium ethanol extracts induce ferroptosis and suppress gastric cancer progression by inhibiting the AKT/GSK3β/NRF2 axis

Phytomedicine, Год журнала: 2025, Номер 142, С. 156789 - 156789

Опубликована: Апрель 24, 2025

Язык: Английский

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Endoplasmic reticulum stress regulates swainsonine-induced the autophagy in renal tubular epithelial cells through UPR signaling pathway

The Science of The Total Environment, Год журнала: 2025, Номер 981, С. 179616 - 179616

Опубликована: Май 11, 2025

Язык: Английский

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