Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 27, 2024
In search of novel natural product-based fungicides, 49 cuminic acid derivatives were designed, synthesized, and screened for their in vitro antifungal effects toward seven phytopathogenic fungi oomycetes. Consequently, several exhibited strong activities
Язык: Английский
Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 6
Опубликована: Июнь 28, 2024
A series of bis(indolyl)-hydrazide-hydrazone derivatives were synthesised, and their structures characterised using
Язык: Английский
Процитировано
1
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Окт. 2, 2024
In order to explore novel antifungal lead compounds from plant essential oil, thirty-two pinonic acid derivatives containing thiourea groups were designed and synthesized using α-pinene as a raw material. One of these compound
Язык: Английский
Процитировано
1
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 18, 2024
Building upon previous structure–activity relationships about the fungicidal amide and hydrazide lead structures, 24 novel amide-hydrazide compounds were designed synthesized with L-isoleucine as initial skeleton to explore impact of substituents in bridge on activity. Among these compounds, A5 exhibited excellent broad spectrum inhibitory activity, along satisfactory vivo protective efficiency against R. solani at concentrations 200 50 μg·mL–1. Scanning electron microscopy (SEM) transmission (TEM) observations revealed that compound induced significant morphological changes mycelium coupled vacuole rupture cytoplasmic inhomogeneity cellular structures. Transcriptomic metabolomic analyses indicated that, following treatment, differentially expressed genes metabolites significantly enriched carbohydrate metabolism-related pathways well lipid metabolism-associated pathways, including glycerophospholipid metabolism, steroid biosynthesis, arachidonic acid sphingolipid metabolism. Additionally, demonstrated low toxicity zebrafish, survival rates 100% 60% 1 10 μg·mL–1, respectively, over a period 7 days. The above results provide theoretical guidance for development green candidates.
Язык: Английский
Процитировано
1
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 27, 2024
In search of novel natural product-based fungicides, 49 cuminic acid derivatives were designed, synthesized, and screened for their in vitro antifungal effects toward seven phytopathogenic fungi oomycetes. Consequently, several exhibited strong activities
Язык: Английский
Процитировано
0