International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2494 - 2494
Опубликована: Фев. 21, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
inflammatory
condition
of
the
digestive
tract
and
closely
associated
with
homeostasis
gut
microbiota.
Inulin,
as
natural
prebiotic,
displays
anti-inflammatory
activity
maintains
equilibrium
intestinal
In
this
study,
our
research
aimed
to
explore
potential
inulin
in
enhancing
immunity
reducing
inflammation
stress-recurrent
IBD.
co-culture
epithelium
model
IBD
mouse
was
used
examine
protective
effects
inulin.
It
observed
that
digesta
significantly
reduced
pro-inflammatory
cytokine
expression
(
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5085 - 5085
Опубликована: Май 7, 2024
The
brain
is
the
central
organ
of
adaptation
to
stress
because
it
perceives
and
determines
threats
that
induce
behavioral,
physiological,
molecular
responses.
In
humans,
chronic
manifests
as
an
enduring
consistent
feeling
pressure
being
overwhelmed
for
extended
duration.
This
can
result
in
a
persistent
proinflammatory
response
peripheral
nervous
system
(CNS),
resulting
cellular,
behavioral
effects.
Compounding
stressors
may
increase
risk
chronic-stress-induced
inflammation,
which
yield
serious
health
consequences,
including
mental
disorders.
review
summarizes
current
knowledge
surrounding
neuroinflammatory
rodent
models
stress—a
relationship
continually
defined.
Many
studies
investigating
effects
on
neuroinflammation
have
identified
significant
changes
inflammatory
modulators,
nuclear
factor-κB
(NF-κB)
toll-like
receptors
(TLRs),
cytokines,
tumor
necrosis
factor-alpha
(TNF-α),
interleukin
(IL)-1β,
IL-6.
suggests
these
are
key
factors
response,
contribute
establishment
anxiety
depression-like
symptoms.
neurological
modulating
through
gene
knockdown
(KD)
knockout
(KO),
conventional
alternative
medicine
approaches,
discussed.
Neural Regeneration Research,
Год журнала:
2024,
Номер
20(7), С. 1829 - 1848
Опубликована: Июль 10, 2024
Subarachnoid
hemorrhage
leads
to
a
series
of
pathological
changes,
including
vascular
spasm,
cellular
apoptosis,
blood–brain
barrier
damage,
cerebral
edema,
and
white
matter
injury.
Microglia,
which
are
the
key
immune
cells
in
central
nervous
system,
maintain
homeostasis
neural
environment,
support
neurons,
mediate
participate
regulation,
have
neuroprotective
effects.
Increasing
evidence
has
shown
that
microglia
play
pivotal
role
pathogenesis
subarachnoid
affect
process
injury
prognosis
hemorrhage.
Moreover,
certain
roles
recovery
phase
Several
approaches
aimed
at
modulating
function
believed
attenuate
This
provides
new
targets
ideas
for
treatment
However,
an
in-depth
comprehensive
summary
after
is
still
lacking.
review
describes
activation
their
processes
vasospasm,
neuroinflammation,
neuronal
disruption,
lesions.
It
also
discusses
during
from
therapeutic
advances
microglial
Currently,
targeted
with
TLR
inhibitors,
nuclear
factor-κB
STAT3
pathway
glycine/tyrosine
kinases,
NLRP3
signaling
Gasdermin
D
vincristine
receptor
α
agonists,
ferroptosis
genetic
modification
techniques,
stem
cell
therapies,
traditional
Chinese
medicine.
most
these
being
evaluated
laboratory
stage.
More
clinical
studies
data
on
required
improve
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
Triterpenoids
derived
from
plants
are
a
promising
class
of
natural
antidepressants.
This
research
focused
on
the
therapeutic
potential
quinoa
saponin
(QS)
in
alleviating
lipopolysaccharide
(LPS)-induced
anxiety
and
depressive-like
behaviors
mice.
The
most
abundant
fraction,
QS–3,
was
isolated
QS
extracts,
its
major
components
chemical
structure
were
elucidated.
Six
pentacyclic
triterpene
saponins
three
tetracyclic
identified
with
phytolaccagenin
oleanolic
acid
being
dominant
sapogenins.
In
vivo
studies
demonstrated
that
significantly
mitigated
LPS-induced
mice,
enhanced
levels
neurotrophic
proteins,
key
synaptic
neurotransmitters,
restored
function
neuronal
damage.
Furthermore,
inhibited
neuroinflammation
by
curtailing
activity
TLR4/MyD88/NF-κB
pathway
modulating
microglial
phenotypes.
Notably,
also
ameliorated
colonic
inflammation
promoting
gut
microbiota
homeostasis
increasing
short-chain
fatty
acids
(SCFAs)
production,
which
contributed
to
improvement
depressive
Our
findings
suggest
holds
as
dietary
supplement
for
treatment
prevention
depression,
possibly
through
modulation
gut-brain
axis
dynamics
suppression
activation
pathway.
