International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2494 - 2494
Published: Feb. 21, 2024
Inflammatory
bowel
disease
(IBD)
is
a
chronic
inflammatory
condition
of
the
digestive
tract
and
closely
associated
with
homeostasis
gut
microbiota.
Inulin,
as
natural
prebiotic,
displays
anti-inflammatory
activity
maintains
equilibrium
intestinal
In
this
study,
our
research
aimed
to
explore
potential
inulin
in
enhancing
immunity
reducing
inflammation
stress-recurrent
IBD.
co-culture
epithelium
model
IBD
mouse
was
used
examine
protective
effects
inulin.
It
observed
that
digesta
significantly
reduced
pro-inflammatory
cytokine
expression
(
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5085 - 5085
Published: May 7, 2024
The
brain
is
the
central
organ
of
adaptation
to
stress
because
it
perceives
and
determines
threats
that
induce
behavioral,
physiological,
molecular
responses.
In
humans,
chronic
manifests
as
an
enduring
consistent
feeling
pressure
being
overwhelmed
for
extended
duration.
This
can
result
in
a
persistent
proinflammatory
response
peripheral
nervous
system
(CNS),
resulting
cellular,
behavioral
effects.
Compounding
stressors
may
increase
risk
chronic-stress-induced
inflammation,
which
yield
serious
health
consequences,
including
mental
disorders.
review
summarizes
current
knowledge
surrounding
neuroinflammatory
rodent
models
stress—a
relationship
continually
defined.
Many
studies
investigating
effects
on
neuroinflammation
have
identified
significant
changes
inflammatory
modulators,
nuclear
factor-κB
(NF-κB)
toll-like
receptors
(TLRs),
cytokines,
tumor
necrosis
factor-alpha
(TNF-α),
interleukin
(IL)-1β,
IL-6.
suggests
these
are
key
factors
response,
contribute
establishment
anxiety
depression-like
symptoms.
neurological
modulating
through
gene
knockdown
(KD)
knockout
(KO),
conventional
alternative
medicine
approaches,
discussed.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Triterpenoids
derived
from
plants
are
a
promising
class
of
natural
antidepressants.
This
research
focused
on
the
therapeutic
potential
quinoa
saponin
(QS)
in
alleviating
lipopolysaccharide
(LPS)-induced
anxiety
and
depressive-like
behaviors
mice.
The
most
abundant
fraction,
QS–3,
was
isolated
QS
extracts,
its
major
components
chemical
structure
were
elucidated.
Six
pentacyclic
triterpene
saponins
three
tetracyclic
identified
with
phytolaccagenin
oleanolic
acid
being
dominant
sapogenins.
In
vivo
studies
demonstrated
that
significantly
mitigated
LPS-induced
mice,
enhanced
levels
neurotrophic
proteins,
key
synaptic
neurotransmitters,
restored
function
neuronal
damage.
Furthermore,
inhibited
neuroinflammation
by
curtailing
activity
TLR4/MyD88/NF-κB
pathway
modulating
microglial
phenotypes.
Notably,
also
ameliorated
colonic
inflammation
promoting
gut
microbiota
homeostasis
increasing
short-chain
fatty
acids
(SCFAs)
production,
which
contributed
to
improvement
depressive
Our
findings
suggest
holds
as
dietary
supplement
for
treatment
prevention
depression,
possibly
through
modulation
gut-brain
axis
dynamics
suppression
activation
pathway.
The FASEB Journal,
Journal Year:
2025,
Volume and Issue:
39(9)
Published: May 7, 2025
ABSTRACT
Fatty
acid
binding
protein
7
(FABP7)
is
prominently
expressed
in
astrocytes
and
a
critical
regulator
of
inflammatory
responses.
Accumulating
evidence
suggests
that
FABP7
crucial
neuropsychological
disease
through
the
modulation
spinogenesis.
Nonetheless,
impact
on
depressive
disorders
underlying
mechanisms
not
fully
understood.
Here,
we
investigated
antidepressant
properties
using
chronic
unpredictable
mild
stress
(CUMS)‐induced
model
depression
possible
mechanisms.
Our
results
revealed
depressive‐like
behavior
induced
by
CUMS
was
associated
with
decreased
levels
hippocampus
(HP).
Furthermore,
overexpression
HP
mitigated
increased
expression
its
downstream
target
caveolin‐1
(Cav‐1).
specifically
regulates
astrocyte
marker
GFAP,
as
well
blood–brain
barrier
(BBB)‐associated
proteins
AQP4,
CLDN‐5,
occludin,
LRP1.
Notably,
CUMS‐induced
upregulation
pro‐inflammatory
factors
IL‐1β
IL‐6
also
significantly
reversed
HP.
This
intervention
led
to
postsynaptic
proteins,
including
PSD95
GluA1,
an
increase
brain‐derived
neurotrophic
factor
(BDNF)
enhanced
neuronal
dendritic
spine
density.
The
findings
indicate
exerts
antidepressant‐like
inhibiting
inflammation,
regulating
spinogenesis,
modulating
BBB‐related
proteins.
