ABSTRACT
Fatty
acid
binding
protein
7
(FABP7)
is
prominently
expressed
in
astrocytes
and
a
critical
regulator
of
inflammatory
responses.
Accumulating
evidence
suggests
that
FABP7
crucial
neuropsychological
disease
through
the
modulation
spinogenesis.
Nonetheless,
impact
on
depressive
disorders
underlying
mechanisms
not
fully
understood.
Here,
we
investigated
antidepressant
properties
using
chronic
unpredictable
mild
stress
(CUMS)‐induced
model
depression
possible
mechanisms.
Our
results
revealed
depressive‐like
behavior
induced
by
CUMS
was
associated
with
decreased
levels
hippocampus
(HP).
Furthermore,
overexpression
HP
mitigated
increased
expression
its
downstream
target
caveolin‐1
(Cav‐1).
specifically
regulates
astrocyte
marker
GFAP,
as
well
blood–brain
barrier
(BBB)‐associated
proteins
AQP4,
CLDN‐5,
occludin,
LRP1.
Notably,
CUMS‐induced
upregulation
pro‐inflammatory
factors
IL‐1β
IL‐6
also
significantly
reversed
HP.
This
intervention
led
to
postsynaptic
proteins,
including
PSD95
GluA1,
an
increase
brain‐derived
neurotrophic
factor
(BDNF)
enhanced
neuronal
dendritic
spine
density.
The
findings
indicate
exerts
antidepressant‐like
inhibiting
inflammation,
regulating
spinogenesis,
modulating
BBB‐related
proteins.
Foods,
Год журнала:
2025,
Номер
14(11), С. 1938 - 1938
Опубликована: Май 29, 2025
As
the
global
elderly
population
is
rising,
concerns
about
cognitive
decline
and
memory
loss
are
becoming
urgent.
This
study
evaluated
potential
of
sea
cucumber
hydrolysates
(SCH)
from
Stichopus
japonicus
in
alleviating
deficits
using
a
D-galactose-induced
murine
aging
model.
The
effects
SCH
on
behavior,
hippocampal
morphology,
gut
microbiota,
cholinergic
system,
brain-derived
neurotrophic
factor
(BDNF)
signaling,
neuroinflammatory
pathways
were
investigated.
Results
showed
that
ameliorated
learning
reduced
neuronal
damage
mice.
also
modulated
along
with
increased
fecal
short-chain
fatty
acids
levels.
Functional
prediction
revealed
alterations
microbiota
related
to
signal
transduction.
Further,
enhanced
function
through
elevating
acetylcholine
(ACh)
levels
inhibiting
acetylcholinesterase
(AChE)
activity
activated
BDNF
consistent
predictions
function.
Restoration
homeostasis
transmission
pathway
might
contribute
inhibition
neuroinflammation
via
suppressing
microglial
activation
nuclear
kappa-B
(NF-κB)
pathway.
In
summary,
attenuated
neuroinflammation,
which
be
correlated
transduction
caused
by
regulating
microbiota.
Further
validation
will
conducted
depletion
transplantation.
These
findings
suggest
promising
functional
component
for
counteracting
aging-related
deficits.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 26, 2024
Depression,
a
mood
disorder
characterized
by
persistent
low
and
lack
of
enjoyment,
is
considered
the
leading
cause
non-fatal
health
losses
worldwide.
Neuroplasticity
refers
to
brain’s
ability
adapt
external
or
internal
stimuli,
resulting
in
functional
structural
changes.
This
process
plays
crucial
role
development
depression.
Traditional
Chinese
Medicine
(TCM)
shows
significant
potential
as
complementary
alternative
therapy
for
neurological
diseases,
including
However,
there
has
been
no
systematic
summary
neuroplasticity
pathological
depression
TCM
Interventions
currently.
review
systematically
summarized
recent
literature
on
changes
analyzed
regulatory
mechanisms
active
metabolites
formulas
antidepressant
treatment.
Additionally,
this
discussed
limitations
current
research
application
prospects
regulating
research.
CNS Neuroscience & Therapeutics,
Год журнала:
2023,
Номер
30(1)
Опубликована: Дек. 18, 2023
Brain
injury
in
preterm
infants
potentially
disrupts
critical
structural
and
functional
connective
networks
the
brain.
It
is
a
major
cause
of
neurological
sequelae
developmental
deficits
infants.
Interesting
findings
suggest
that
gut
microbiota
(GM)
their
metabolites
contribute
to
programming
central
nervous
system
(CNS)
during
stages
may
exert
effects
throughout
lifespan.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 12, 2023
Depression
is
characterized
by
prominent
indicators
and
manifestations,
such
as
anhedonia,
which
refers
to
the
inability
experience
pleasure,
persistent
feelings
of
hopelessness.
In
clinical
practice,
primary
treatment
approach
involves
utilization
selective
serotonin
reuptake
inhibitors
(SSRIs)
related
pharmacological
interventions.
Nevertheless,
it
crucial
recognize
that
these
agents
are
associated
with
significant
adverse
effects.
Traditional
Chinese
medicine
(TCM)
adopts
a
multifaceted
approach,
targeting
diverse
components,
multiple
targets,
various
channels
action.
TCM
has
potential
antidepressant
Anomalies
in
adult
hippocampal
neurogenesis
(AHN)
constitute
pivotal
factor
pathology
depression,
regulation
AHN
emerging
key
measure
intervene
pathogenesis
progression
this
condition.
This
comprehensive
review
presented
an
overview
mechanisms
underlying
effects
active
ingredients
found
TCM.
Through
examination
recent
studies,
we
explored
how
modulated
AHN.
Furthermore,
critically
assessed
current
limitations
research
domain
proposed
novel
strategies
for
preclinical
investigation
applications
depression
future.
Inulin,
an
increasingly
studied
dietary
fiber,
alters
intestinal
microbiota.
The
aim
of
this
study
was
to
assess
whether
inulin
decreases
colonization
by
multidrug
resistant
As
the
population
ages,
functional
dietary
supplements
are
increasingly
used
to
reduce
age-related
diseases,
especially
in
field
of
cognitive
impairment.
In
this
study,
a
thyroxine
(Th)-induced
aging
model
was
established,
and
effect
proanthocyanidins
(Pc)
on
impairment
mice
evaluated
based
ability,
neuroinflammation
immune
level.
The
results
showed
that
Pc
significantly
reduced
AchE
activity
compared
Model
group,
improving
learning
deficits
spatial
memory
aged
(
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4286 - 4286
Опубликована: Дек. 12, 2024
The
microbiota
stability,
diversity,
and
composition
are
pillars
for
an
efficient
beneficial
symbiotic
relationship
between
its
host
itself.
Microbial
dysbiosis,
a
condition
where
homeostatic
bacterial
community
is
disturbed
by
acute
or
chronic
events,
predisposition
many
diseases,
including
local
systemic
inflammation
that
leads
to
metabolic
syndrome,
diabetes,
some
types
of
cancers.
Classical
dysbiosis
occurs
in
the
large
intestine.
During
this
period,
pathogenic
strains
can
multiply,
taking
advantage
compromised
environment.
This
overgrowth
triggers
exaggerated
inflammatory
response
from
human
immune
system
due
weakened
integrity
intestinal
barrier.
Such
also
directly
influence
higher
polyp
formation
and/or
tumorigenesis.
Prebiotics
be
instrumental
preventing
correcting
dysbiosis.
molecules
capable
serving
as
substrates
fermentation
processes
gut
microorganisms.
promote
returning
environment
homeostasis.
Effective
prebiotics
generally
specific
oligo-
polysaccharides,
such
FOS
inulin.
However,
direct
effects
on
epithelial
cells
must
taken
into
consideration.
interaction
happens
with
diverse
prebiotic
nondigestible
carbohydrates,
they
inhibit
decrease
response.
present
work
aims
elucidate
describe
different
prebiotics,
their
influence,
functionalities
health,
primarily
focusing
ability
reduce
control
barrier,
gut,
environments.
