Empagliflozin ameliorates olfactory bulbectomy-induced depression by mitigating oxidative stress and possible involvement of brain derived neurotrophic factor in diabetic rats DOI
Sachin P. Borikar,

Gaurav V. Chitode,

Deepali N. Tapre

и другие.

International Journal of Neuroscience, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Окт. 11, 2024

Empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has recently reported to prevent the depression in chronic animal model. The present study aimed explore antidepressant potential of empagliflozin using neuroinflammation-mediated involving olfactory bulbectomy (OBX) model diabetic rats. A low dose streptozotocin was injected induce diabetes all group animals. Following confirmation hyperglycemia, OBX surgery performed. Post-surgery, drug treatments were administered orally for 14 consecutive days. evaluated effects daily oral administration at doses 5 and 10 mg/kg, alongside metformin (200 mg/kg) clomipramine (50 mg/kg), on OBX-induced behavioral Separate sham vehicle control groups also maintained. Behavioral parameters open field, forced swim test, elevated plus maze splash test recorded 28

Язык: Английский

Empagliflozin ameliorates olfactory bulbectomy-induced depression by mitigating oxidative stress and possible involvement of brain derived neurotrophic factor in diabetic rats DOI
Sachin P. Borikar,

Gaurav V. Chitode,

Deepali N. Tapre

и другие.

International Journal of Neuroscience, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Окт. 11, 2024

Empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has recently reported to prevent the depression in chronic animal model. The present study aimed explore antidepressant potential of empagliflozin using neuroinflammation-mediated involving olfactory bulbectomy (OBX) model diabetic rats. A low dose streptozotocin was injected induce diabetes all group animals. Following confirmation hyperglycemia, OBX surgery performed. Post-surgery, drug treatments were administered orally for 14 consecutive days. evaluated effects daily oral administration at doses 5 and 10 mg/kg, alongside metformin (200 mg/kg) clomipramine (50 mg/kg), on OBX-induced behavioral Separate sham vehicle control groups also maintained. Behavioral parameters open field, forced swim test, elevated plus maze splash test recorded 28

Язык: Английский

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