Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis

Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown, С. 108831 - 108831

Опубликована: Фев. 1, 2025

Язык: Английский

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Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota

International Immunopharmacology, Год журнала: 2024, Номер 132, С. 112024 - 112024

Опубликована: Апрель 11, 2024

Язык: Английский

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TRPA1-Activated Peptides from Saiga Antelope Horn: Screening, Interaction Mechanism, and Bioactivity

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2119 - 2119

Опубликована: Фев. 27, 2025

Saiga antelope horn (SAH), a rare traditional Chinese medicine, exhibits activities of anti-feverish convulsions and anti-inflammation, whereas its underlying mechanism specific pharmacological components are still unclear. In the present study, transient receptor potential ankyrin 1 (TRPA1), major cation channel was used as target protein to identified TRPA1 high-affinity peptides (THPs) from SAH digests. Firstly, digested under in vitro gastrointestinal conditions. With method affinity ultrafiltration liquid chromatography-mass spectrometry (AUF-LC/MS), about 200 that have interaction with were screened Subsequently, bioactivity databases molecular docking further exploited three THPs, including RCWPDCR, FGFDGDF, WFCEGSF. Furthermore, RIN-14B cells, characterized by high expression on cell surfaces, model investigate biological effect THPs. Immunofluorescence ELISA conducted showed THPs can increase intracellular Ca2+ concentration serotonin (5-HT) secretion cells activating TRPA1, which is evidenced impaired upregulation levels 5-HT after pretreatment inhibitor (HC-030031). Moreover, an analysis Western blots displayed up-regulated synthesis rate-limiting enzyme (TPH1) 5-hydroxytryptophan decarboxylase (Ddc), while reuptake transporter (SERT) down-regulated, suggesting enhance regulating pathway. summary, our findings demonstrate digest via TRPA1-targeted panning, exhibited activation enhanced release cells.

Язык: Английский

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Induction of multicomponent peptide assembly via solvent exchange strategy for enhanced structure and bioactivities

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157484 - 157484

Опубликована: Ноя. 1, 2024

Язык: Английский

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Dual-modified starch micelles as nanocarriers for efficient encapsulation and controlled release of walnut-derived active peptides

Food Chemistry, Год журнала: 2024, Номер 454, С. 139750 - 139750

Опубликована: Май 23, 2024

Язык: Английский

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Research progress on the protection and mechanism of active peptides in Alzheimer's disease and Parkinson's disease

Neuropeptides, Год журнала: 2024, Номер 107, С. 102457 - 102457

Опубликована: Июль 25, 2024

Язык: Английский

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Potential of Using Walnuts as a Part of Nutritional Therapy for Inflammatory Bowel Diseases

Педиатрическая фармакология, Год журнала: 2025, Номер 22(1), С. 56 - 61

Опубликована: Фев. 26, 2025

Walnuts are major component of Mediterranean and Asian diets increasingly used in different around the world due to their confirmed nutritional health benefits. Walnuts’ components abundant with omega-3 polyunsaturated fatty acids, essential amino vitamins, polyphenols, phytosterols, other nutrients biologically active compounds antioxidant, anti-inflammatory immunomodulating properties. currently have demonstrated promising effect inflammatory bowel diseases management. This study presents key mechanisms underlying walnuts’ therapeutic potential management, such as modulation intestinal mucosa permeability, processes regulation, oxidative stress reduction, gut microbiota composition correction.

Язык: Английский

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Synergistic protective effects of probiotics Lactiplantibacillus plantarum S58 and prebiotics Qingke β-glucan on dextran sulfate sodium-induced cognitive deficits in colitis mice: A study of microbial-gut-brain axis modulation

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106266 - 106266

Опубликована: Март 1, 2025

Язык: Английский

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Walnut‐derived peptides combined with intermittent fasting alleviated obesity by modulating gut microbiota and liver metabolome in high‐fat‐diet‐induced obesity mice

Journal of the Science of Food and Agriculture, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Abstract BACKGROUND This study aimed to investigate the anti‐obesity mechanism of walnut‐derived peptides (WMP) combined with intermittent fasting (IF) through modulating gut microbiota–liver metabolism axis in high‐fat‐diet (HFD)‐induced obese mice, providing theoretical support for dietary intervention strategies. METHODS Fifty C57BL/6 mice were divided into five groups ( n = 10): normal diet, HFD, WMP, IF and WMP + IF, an 8‐week intervention. Biochemical analysis, 16S rRNA sequencing, untargeted liver metabolomics employed explore underlying mechanisms. RESULTS significantly alleviated hyperlipidemia, glucose disorders, insulin resistance, visceral fat deposition HFD while suppressing systemic inflammation. Gut microbiota analysis revealed reduced abundance Firmicutes , Kineothrix Dubosiella along a decreased / Bacteroidota (F/B) ratio, whereas CAG‐873 enriched. Correlation demonstrated positive associations between obesity‐related markers (lipid profiles, dysfunction, pro‐inflammatory cytokines), exhibited negative correlations. Untargeted identified upregulated levels 16‐hydroxypalmitic acid 13‐S‐hydroxyoctadecadienoic (13(S)‐HODE), alongside activation ABC transporters galactose pathways. Notably, 13(S)‐HODE showed correlations F/B but . CONCLUSION The synergistic effects are mediated restoring microbial balance reprogramming hepatic metabolic These findings highlight novel mechanisms involving gut–liver axis, offering innovative strategies obesity prevention natural bioactive compounds interventions. © 2025 Society Chemical Industry.

Язык: Английский

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Chensinin-1b Alleviates DSS-Induced Inflammatory Bowel Disease by Inducing Macrophage Switching from the M1 to the M2 Phenotype

Biomedicines, Год журнала: 2024, Номер 12(2), С. 345 - 345

Опубликована: Фев. 1, 2024

Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder with an increasing prevalence worldwide. Macrophage polarization involved in the pathogenesis of IBD. Repolarization macrophage has thus emerged as novel therapeutic approach for managing Chensinin-1b, derived from skin Rana chensinensis, derivative native antimicrobial peptide (AMP). It shows anti-inflammatory effects sepsis models and can potentially modulate polarization. The objective this research was to study role chensinin-1b dextran sulfate sodium (DSS)-induced colitis. RAW264.7 macrophages were polarized M1 phenotype using lipopolysaccharide (LPS) simultaneously administered at various concentrations. ability chenisnin-1b reorient assessed by ELISA, qRT-PCR, flow cytometry analysis. addition significantly restrained expression M1-associated proinflammatory cytokines surface markers, including TNF-α, IL-6, NO, CD86, exaggerated M2-associated IL-10, TGF-β1, Arg-1, Fizz1, Chil3, CD206. Mechanistically, via Western Blotting, we revealed that induces M2 inhibiting phosphorylation nuclear factor-kappa B (NF-κB) mitogen-activated protein kinase (MAPK). In mouse colitis, intraperitoneal administration alleviated symptoms induced DSS, weight loss, elevated activity index (DAI) scores, colon shortening, colonic tissue damage, splenomegaly. Consistent our vitro data, significant decreases biomarkers increases colitis model. Furthermore, treatment repressesed NF-κB vivo. Overall, data showed attenuates IBD repolarizing phenotype, suggesting its potential candidate

Язык: Английский

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