Design, Synthesis, and Fungicidal Activity of α-Methylene-γ-Butyrolactone Derivatives Bearing a Diphenyl Ether Moiety DOI
Caiyun Chen, Hong‐Wei He, Dan Xu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

The γ-butyrolactone scaffold, commonly present in natural products and bioactive compounds, has played a crucial role the development of novel pesticides. In this study, series α-methylene-γ-butyrolactone derivatives containing diphenyl ether moiety were designed synthesized using scaffold splicing strategy. Bioassays revealed that several target compounds demonstrated potent fungicidal activities, particularly against Phytophthora capsici Valsa mali. Notably, compound B7 (EC50 = 0.809 mg/L) exhibited highest antioomycete activity P. capsici, outperforming famoxadone 41.0 but being less effective than dimethomorph 0.180 mg/L). Meanwhile, C22 1.47 showed strongest antifungal V. mali, which was higher those 1.80 13.6 vivo experiments confirmed satisfactory protective curative effects better famoxadone. Additionally, found to inhibit sporangia formation, zoospore release, cystospore germination at 10 mg/L. Physiological biochemical studies indicated can induce changes mycelial morphology increase cell membrane permeability, modulate respiratory metabolism. Furthermore, both vitro enzymatic inhibition assays molecular docking analysis suggested primary mechanism action may involve binding complex III on chain. This work provides valuable insights for incorporating as agricultural agents.

Language: Английский

Frontier Exploration of Synthesis and Biological Activity of Vanillin Derivatives DOI

丽琼 张

Journal of Organic Chemistry Research, Journal Year: 2025, Volume and Issue: 13(01), P. 13 - 20

Published: Jan. 1, 2025

Language: Английский

Citations

0
Herbicidal activity and biochemical characteristics of the natural product australol and preparation of an australol‐based emulsifiable concentrate DOI
Yuxin Cao,

Yanpu Meng,

Shujuan Li

et al.

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Abstract BACKGROUND Botanical herbicides play a crucial role in agricultural sustainability and environmental protection. This study elucidated the herbicidal activity biochemical characteristics of australol, successfully developed an australol‐based emulsifiable concentrate (EC). The research lays foundation for development application novel botanical herbicides. RESULTS Australol exhibits significant activity, inhibition rates root length stem Echinochloa crusgalli Amaranthus tricolor were both 100% when concentration australol is 1 mg/mL. In pot experiment, treated with at 10 mg/mL 7 days, on fresh weight E. , Abutilon theophrasti 89.50%, 82.69%, 86.35%, respectively. can destroy tip cell morphology structure . It also increase content malondialdehyde, peroxidase was significantly increased. When 20% EC mg/mL, rate 100%. 38% atrazine suspension (SC) reduced by 30% combined EC, aboveground parts are CONCLUSION natural compound has inhibitory effect growth weed seedlings disrupting membrane weeds. An prepared, which achieve reducing chemical pesticide usage while enhancing efficacy. © 2025 Society Chemical Industry.

Language: Английский

Citations

0
A rapid, efficient microwave-assisted synthesis of novel bis-pyrazole analogues using non-toxic and cost-effective catalyst under green solvent medium DOI

Komati Satish Kumar,

Alice R. Robert,

Adapaka Venkateswara Rao

et al.

Chemical Data Collections, Journal Year: 2024, Volume and Issue: unknown, P. 101165 - 101165

Published: Sept. 1, 2024

Language: Английский

Citations

1
Design, Synthesis, and Herbicidal Activity Study of Novel Pyrazole-Carboxamides as Potential Transketolase Inhibitors DOI
Chengkun Li, Junmin Wang, Haijiao Dong

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Transketolase (TKL; EC 2.2.1.1) has been identified as a potential new herbicide target. In order to discover highly herbicidal active compounds targeting TKL and improve their structural diversity for lead compounds, series of pyrazole-carboxamides 7a–7v were designed synthesized through optimization pyrazole-containing phenoxy amide compound 4u. Among the 7r possessed excellent efficacy against Digitaria sanguinalis (Ds) Amaranthus retroflexus (Ar) by small cup method (the inhibition about 95%, 100 mg/L) foliar spray over 90%, 150 g ai/ha) in greenhouse, which superior that positive control nicosulfuron. More significantly, displayed good crop selectivity toward both maize wheat even at 375 ai/ha. The studies on mode action (MOA) high including enzyme activity, fluorescent quenching experiments, molecular docking analysis between Setaria viridis (Sv)TKL ligand, suggested acts typical inhibitor, benzothiazole ring is an important motif SvTKL activity. Above all, could be candidate development herbicides with MOA weed field.

Language: Английский

Citations

1
Design, Synthesis, and Fungicidal Activity of α-Methylene-γ-Butyrolactone Derivatives Bearing a Diphenyl Ether Moiety DOI
Caiyun Chen, Hong‐Wei He, Dan Xu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

The γ-butyrolactone scaffold, commonly present in natural products and bioactive compounds, has played a crucial role the development of novel pesticides. In this study, series α-methylene-γ-butyrolactone derivatives containing diphenyl ether moiety were designed synthesized using scaffold splicing strategy. Bioassays revealed that several target compounds demonstrated potent fungicidal activities, particularly against Phytophthora capsici Valsa mali. Notably, compound B7 (EC50 = 0.809 mg/L) exhibited highest antioomycete activity P. capsici, outperforming famoxadone 41.0 but being less effective than dimethomorph 0.180 mg/L). Meanwhile, C22 1.47 showed strongest antifungal V. mali, which was higher those 1.80 13.6 vivo experiments confirmed satisfactory protective curative effects better famoxadone. Additionally, found to inhibit sporangia formation, zoospore release, cystospore germination at 10 mg/L. Physiological biochemical studies indicated can induce changes mycelial morphology increase cell membrane permeability, modulate respiratory metabolism. Furthermore, both vitro enzymatic inhibition assays molecular docking analysis suggested primary mechanism action may involve binding complex III on chain. This work provides valuable insights for incorporating as agricultural agents.

Language: Английский

Citations

0