Neuroinflammation of Microglial Regulation in Alzheimer’s Disease: Therapeutic Approaches
Molecules,
Год журнала:
2024,
Номер
29(7), С. 1478 - 1478
Опубликована: Март 26, 2024
Alzheimer’s
disease
(AD)
is
a
complex
degenerative
of
the
central
nervous
system
that
clinically
characterized
by
progressive
decline
in
memory
and
cognitive
function.
The
pathogenesis
AD
intricate
not
yet
fully
understood.
Neuroinflammation,
particularly
microglial
activation-mediated
neuroinflammation,
believed
to
play
crucial
role
increasing
risk,
triggering
onset,
hastening
progression
AD.
Modulating
activation
regulating
energy
metabolic
disorder
are
seen
as
promising
strategies
intervene
application
anti-inflammatory
drugs
targeting
microglia
for
prevention
treatment
has
emerged
new
area
research
interest.
This
article
provides
comprehensive
review
neuroinflammation
regulation
development
AD,
exploring
connection
between
disorder,
development.
Additionally,
advancements
microglia-regulating
therapies
discussed.
Язык: Английский
Xinnaoxin capsule alleviates neuropathological changes and cognitive deficits in Alzheimer’s disease mouse model induced by D-galactose and aluminum chloride via reducing neuroinflammation and protecting synaptic proteins
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119323 - 119323
Опубликована: Янв. 1, 2025
Язык: Английский
A novel bacillus-shaped CoNi ZIF-MXene@MWCNT carbon cloth electrochemical sensor for sensitive detection of salidroside
Microchemical Journal,
Год журнала:
2024,
Номер
204, С. 111055 - 111055
Опубликована: Июнь 24, 2024
Язык: Английский
Therapeutic role of NLRP3 inflammasome inhibitors against Alzheimer’s disease
Tanmoy Tantra,
Abdul Rahaman T A,
Nandini Nandini
и другие.
Bioorganic Chemistry,
Год журнала:
2024,
Номер
153, С. 107912 - 107912
Опубликована: Окт. 23, 2024
Язык: Английский
Molecular mechanism of PANoptosis and programmed cell death in neurological diseases
Ketian Hou,
Weihong Pan,
L.-Y. Liu
и другие.
Neurobiology of Disease,
Год журнала:
2025,
Номер
unknown, С. 106907 - 106907
Опубликована: Апрель 1, 2025
PANoptosis
represents
a
highly
coordinated
inflammatory
programmed
cell
death
governed
by
the
assembly
and
activation
of
PANoptosome,
which
strategically
integrate
core
molecular
elements
from
pyroptosis,
apoptosis,
necroptosis.
The
triple-component
pathways
set
themselves
apart
alternative
regulated
mechanisms
through
their
unique
capacity
to
concurrently
process
signals
derived
multiple
death-signaling
modalities,
thereby
coordinating
multifaceted
cellular
defense
system
against
diverse
pathological
insults.
Pathogen-associated
patterns
synergistically
interact
with
cytokine
storms,
oncogenic
stress
active
PANoptosis,
establishing
this
pathway
as
critical
nexus
in
pathogenesis
tumor
immunomodulation.
This
crosstalk
highlights
promising
therapeutic
target
for
managing
immune-related
disorders
malignant
transformation.
Emerging
evidence
links
neuroinflammatory
dysregulated
between
(apoptosis,
necroptosis,
pyroptosis)
accidental
necrosis,
driving
neuronal
loss
neural
damage.
Single-cell
transcriptomics
reveals
spatially
resolved
signatures
Alzheimer's
hippocampal
microenvironments
sclerosis
demyelinating
plaques,
distinct
clusters
correlating
quantifiable
metrics.
PANoptosis-targeted
therapies
show
preclinical
promise
alleviating
neurovascular
dysfunction
while
preserving
physiological
microglial
surveillance
functions.
Accumulating
linking
(particularly
PANoptosis)
neurological
underscores
urgency
deciphering
its
developing
precision
modulators
next-generation
therapies.
review
systematically
deciphers
PANoptosome
associated
cascades,
evaluates
roles
multiscale
regulatory
networks,
proposes
frameworks
advance
neurology.
Язык: Английский
A Review on Traditional Uses, Phytochemistry, Pharmacology and Clinical Application of Tinospora sinensis (Lour.) Merr
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(6)
Опубликована: Март 28, 2024
Abstract
Tinospora
sinensis
(
T.
),
whose
Tibetan
name
is
“Lezhe”,
as
a
traditional
medicine,
widely
distributed
in
China,
India
and
Sri
Lanka.
It
used
for
the
treatment
of
rheumatic
arthralgia,
sciatica,
lumbar
muscle
strain
bruises.
Research
over
previous
decades
indicated
that
mainly
contains
terpenes,
lignans,
alkaloids,
phenol
glycosides
other
chemical
components.
A
wide
range
pharmacologic
activities
such
anti‐inflammatory,
analgesic,
immunosuppressive,
anti‐aging,
anti‐radiation,
anti‐leishmania
liver
protection
have
been
reported.
However,
scholar's
research
on
pharmacodynamic
material
basis
relatively
weak.
Data
regarding
many
aspects
links
between
uses
bioactivities,
pharmacokinetics,
quality
control
standard
active
compositions
still
limited
need
more
attention.
This
review
reports
total
241
compounds,
ethnopharmacology
clinical
application
,
covering
literature
which
were
searched
by
multiple
databases
including
Web
Science,
PubMed,
Google
Scholar,
Science
Direct,
CNKI
sources
from
1996
to
date,
with
view
provide
systematic
insightful
reference
lays
foundation
inspiration
further
in‐depth
resources.
Язык: Английский
The antibacterial potential and effects of Rhodiola sp. on gut microbiota
Phytochemistry Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 27, 2024
Abstract
The
challenge
of
antimicrobial
resistance
requires
new
solutions,
and
Rhodiola
sp.
is
a
promising
candidate
due
to
its
rich
medicinal
history.
This
review
focuses
on
sp.,
especially
R.
rosea
,
highlighting
phytochemical
constituents,
such
as
salidroside,
rosavins,
other
phenolics,
their
potential.
We
investigate
the
efficacy
against
various
pathogenic
bacteria,
suggesting
value
in
combating
resistance.
Additionally,
compounds
are
being
investigated
both
direct
antimicrobials
modifiers
that
increase
antibiotics.
extracts
salidroside
modulate
gut
microbiota,
thereby
affecting
health
physiological
metabolic
disorders.
illustrates
comprehensive
therapeutic
potential
emphasize
importance
understanding
complex
interactions
between
phytochemicals,
effects,
effects
microbiota
well
need
for
in-depth
research.
Further
studies
will
be
crucial
development
holistic
treatment
approaches.
Finally,
highlighted
an
important
natural
resource
fight
microbial
pathogens
antibiotic
Research
should
continue
further
unravel
pharmacological
health-promoting
thus
address
public
challenge.
Язык: Английский
Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 10421 - 10440
Опубликована: Дек. 1, 2024
Despite
advancements
in
cancer
treatment
through
surgery
and
drugs,
hepatocellular
carcinoma
(HCC)
remains
a
significant
challenge,
as
reflected
by
its
low
survival
rates.
The
mammalian
target
of
rapamycin
(mTOR)
signaling
pathway
plays
crucial
role
regulating
the
cell
cycle,
proliferation,
apoptosis,
metabolism.
Notably,
dysregulation
leading
to
activation
mTOR
is
common
HCC,
making
it
key
focus
for
in-depth
research
current
therapeutic
strategies.
This
review
focuses
on
downstream
effectors
HCC
autophagy,
metabolic
reprogramming.
Moreover,
emphasizes
potential
natural
products
modulators
pathway.
When
incorporated
into
combination
therapies,
these
have
been
demonstrated
augment
efficacy
surmount
drug
resistance.
These
pathways
such
pathways.
Examples
include
11-epi-sinulariolide
acetate,
matrine,
asparagus
polysaccharide.
Their
inhibitory
effects
processes
suggest
valuable
directions
development
more
effective
Various
ability
inhibit
suppress
progression.
phytochemicals,
functioning
inhibitors,
hold
great
promise
anti-HCC
agents,
especially
context
overcoming
chemoresistance
enhancing
outcomes
therapies.
Язык: Английский
A Novel Bacillus-Shaped Coni Zif-Mxene@Mwcnt Cc Electrochemical Sensor for Sensitive Detection of Salidroside
Опубликована: Янв. 1, 2024
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Язык: Английский
Phytochemicals targeting mitophagy: Therapeutic opportunities and prospects for treating Alzheimer’s disease
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117144 - 117144
Опубликована: Июль 14, 2024
Alzheimer's
disease
(AD)
is
a
prevalent
neurodegenerative
disorder
and
the
leading
cause
of
age-related
cognitive
decline.
Recent
studies
have
established
close
relationship
between
mitophagy
pathogenesis
AD.
Various
phytochemicals
shown
promising
therapeutic
effects
in
mitigating
onset
progression
This
review
offers
comprehensive
overview
typical
features
underlying
mechanisms
to
its
occurrence
AD,
highlighting
significance
disease's
progression.
Additionally,
we
examine
synthetic
drugs
that
induce
Finally,
summarize
recent
advances
research
on
regulate
treatment
potentially
guiding
development
new
anti-AD
drugs.
Язык: Английский