Published: Jan. 1, 2024
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Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 29(7), P. 1478 - 1478
Published: March 26, 2024
Alzheimer’s disease (AD) is a complex degenerative of the central nervous system that clinically characterized by progressive decline in memory and cognitive function. The pathogenesis AD intricate not yet fully understood. Neuroinflammation, particularly microglial activation-mediated neuroinflammation, believed to play crucial role increasing risk, triggering onset, hastening progression AD. Modulating activation regulating energy metabolic disorder are seen as promising strategies intervene application anti-inflammatory drugs targeting microglia for prevention treatment has emerged new area research interest. This article provides comprehensive review neuroinflammation regulation development AD, exploring connection between disorder, development. Additionally, advancements microglia-regulating therapies discussed.
Language: Английский
Citations
14
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119323 - 119323
Published: Jan. 1, 2025
Language: Английский
Citations
1
Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106907 - 106907
Published: April 1, 2025
PANoptosis represents a highly coordinated inflammatory programmed cell death governed by the assembly and activation of PANoptosome, which strategically integrate core molecular elements from pyroptosis, apoptosis, necroptosis. The triple-component pathways set themselves apart alternative regulated mechanisms through their unique capacity to concurrently process signals derived multiple death-signaling modalities, thereby coordinating multifaceted cellular defense system against diverse pathological insults. Pathogen-associated patterns synergistically interact with cytokine storms, oncogenic stress active PANoptosis, establishing this pathway as critical nexus in pathogenesis tumor immunomodulation. This crosstalk highlights promising therapeutic target for managing immune-related disorders malignant transformation. Emerging evidence links neuroinflammatory dysregulated between (apoptosis, necroptosis, pyroptosis) accidental necrosis, driving neuronal loss neural damage. Single-cell transcriptomics reveals spatially resolved signatures Alzheimer's hippocampal microenvironments sclerosis demyelinating plaques, distinct clusters correlating quantifiable metrics. PANoptosis-targeted therapies show preclinical promise alleviating neurovascular dysfunction while preserving physiological microglial surveillance functions. Accumulating linking (particularly PANoptosis) neurological underscores urgency deciphering its developing precision modulators next-generation therapies. review systematically deciphers PANoptosome associated cascades, evaluates roles multiscale regulatory networks, proposes frameworks advance neurology.
Language: Английский
Citations
0
Microchemical Journal, Journal Year: 2024, Volume and Issue: 204, P. 111055 - 111055
Published: June 24, 2024
Language: Английский
Citations
3
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107912 - 107912
Published: Oct. 23, 2024
Language: Английский
Citations
3
Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(6)
Published: March 28, 2024
Abstract Tinospora sinensis ( T. ), whose Tibetan name is “Lezhe”, as a traditional medicine, widely distributed in China, India and Sri Lanka. It used for the treatment of rheumatic arthralgia, sciatica, lumbar muscle strain bruises. Research over previous decades indicated that mainly contains terpenes, lignans, alkaloids, phenol glycosides other chemical components. A wide range pharmacologic activities such anti‐inflammatory, analgesic, immunosuppressive, anti‐aging, anti‐radiation, anti‐leishmania liver protection have been reported. However, scholar's research on pharmacodynamic material basis relatively weak. Data regarding many aspects links between uses bioactivities, pharmacokinetics, quality control standard active compositions still limited need more attention. This review reports total 241 compounds, ethnopharmacology clinical application , covering literature which were searched by multiple databases including Web Science, PubMed, Google Scholar, Science Direct, CNKI sources from 1996 to date, with view provide systematic insightful reference lays foundation inspiration further in‐depth resources.
Language: Английский
Citations
2
Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: April 27, 2024
Abstract The challenge of antimicrobial resistance requires new solutions, and Rhodiola sp. is a promising candidate due to its rich medicinal history. This review focuses on sp., especially R. rosea , highlighting phytochemical constituents, such as salidroside, rosavins, other phenolics, their potential. We investigate the efficacy against various pathogenic bacteria, suggesting value in combating resistance. Additionally, compounds are being investigated both direct antimicrobials modifiers that increase antibiotics. extracts salidroside modulate gut microbiota, thereby affecting health physiological metabolic disorders. illustrates comprehensive therapeutic potential emphasize importance understanding complex interactions between phytochemicals, effects, effects microbiota well need for in-depth research. Further studies will be crucial development holistic treatment approaches. Finally, highlighted an important natural resource fight microbial pathogens antibiotic Research should continue further unravel pharmacological health-promoting thus address public challenge.
Language: Английский
Citations
2
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10421 - 10440
Published: Dec. 1, 2024
Despite advancements in cancer treatment through surgery and drugs, hepatocellular carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The mammalian target of rapamycin (mTOR) signaling pathway plays crucial role regulating the cell cycle, proliferation, apoptosis, metabolism. Notably, dysregulation leading to activation mTOR is common HCC, making it key focus for in-depth research current therapeutic strategies. This review focuses on downstream effectors HCC autophagy, metabolic reprogramming. Moreover, emphasizes potential natural products modulators pathway. When incorporated into combination therapies, these have been demonstrated augment efficacy surmount drug resistance. These pathways such pathways. Examples include 11-epi-sinulariolide acetate, matrine, asparagus polysaccharide. Their inhibitory effects processes suggest valuable directions development more effective Various ability inhibit suppress progression. phytochemicals, functioning inhibitors, hold great promise anti-HCC agents, especially context overcoming chemoresistance enhancing outcomes therapies.
Language: Английский
Citations
2
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117144 - 117144
Published: July 14, 2024
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder and the leading cause of age-related cognitive decline. Recent studies have established close relationship between mitophagy pathogenesis AD. Various phytochemicals shown promising therapeutic effects in mitigating onset progression This review offers comprehensive overview typical features underlying mechanisms to its occurrence AD, highlighting significance disease's progression. Additionally, we examine synthetic drugs that induce Finally, summarize recent advances research on regulate treatment potentially guiding development new anti-AD drugs.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Language: Английский
Citations
0