International Journal of Biological Macromolecules, Год журнала: 2024, Номер 290, С. 139041 - 139041
Опубликована: Дек. 19, 2024
Язык: Английский
Advances in Nutrition, Год журнала: 2025, Номер unknown, С. 100376 - 100376
Опубликована: Янв. 1, 2025
Aging is associated with the decline of tissue and cellular functions, which can promote development age-related diseases like cancer, cardiovascular disease, neurodegeneration, disorders musculoskeletal immune systems. Healthspan length time an individual in good health free from chronic disabilities aging. Two modifiable factors that influence healthspan, healthy aging, prevent diseases, are diet microbiota gastrointestinal tract (gut microbiota). This review will discuss how dietary phytochemicals gut work concert to a First overview provided influences aging through its impact on barrier integrity, function, mitochondria function oxidative stress. Next, mechanisms by effect health, inflammation, nurture diverse microbial composition discussed. Lastly, directly producing bioactive metabolites food urolithin A, equol, hesperetin sulforaphane. These other phytochemical derived may healthspan Importantly, individual's capacity produce promoting cruciferous vegetables, berries, nuts, citrus soy products be dependent specific bacteria present gut.
Язык: Английский
Процитировано
2
Advanced Materials, Год журнала: 2024, Номер 36(41)
Опубликована: Сен. 2, 2024
Ferroptosis in neurons is considered one of the key factors that induces Parkinson's disease (PD), which caused by excessive iron accumulation intracellular labile pool (LIP). The ions released from LIP lead to aberrant generation reactive oxygen species (ROS) trigger ferroptosis and exacerbate PD progression. Herein, a pioneering design multifunctional nanoregulator deferoxamine (DFO)-integrated nanosheets (BDPR NSs) presented target restrict protect against PD. BDPR NSs are constructed incorporating brain-targeting peptide DFO into polydopamine-modified black phosphorus nanosheets. These can sequester free ions, thereby ameliorating overload regulating metabolism. Furthermore, decrease lipid peroxidation mitigating ROS accumulation. More importantly, specifically accumulate mitochondria suppress mitochondrial In vivo experiments demonstrated highly efficiently mitigated dopaminergic neuronloss its associated behavioral disorders modulating inhibiting ferroptosis. Thus, BDPR-based nanovectors holds promise as potential avenue for advancing therapy.
Язык: Английский
Процитировано
7
NeuroToxicology, Год журнала: 2024, Номер 101, С. 117 - 127
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
6
Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137537 - 137537
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1636 - 1636
Опубликована: Янв. 29, 2024
Alzheimer’s disease and Type 2 diabetes are two epidemiologically linked diseases which closely associated with the misfolding aggregation of amyloid proteins amyloid-β (Aβ) human islet polypeptide (hIAPP), respectively. The co-aggregation is regarded as fundamental molecular mechanism underlying their pathological association. green tea extract epigallocatechin-3-gallate (EGCG) has been extensively demonstrated to inhibit Aβ hIAPP proteins. However, its potential role in not thoroughly investigated. In this study, we employed enhanced-sampling replica exchange dynamics simulation (REMD) method investigate effect EGCG on hIAPP. We found that molecules substantially diminish β-sheet structures within core regions co-aggregates. Through hydrogen-bond, π–π cation–π interactions targeting polar aromatic residues hIAPP, effectively attenuates both inter-chain intra-chain All these findings indicated can Our study expands applications an anti-amyloidosis agent provides therapeutic options for association disorders.
Язык: Английский
Процитировано
2
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Окт. 23, 2024
Parkinson's disease (PD), as a refractory neurological disorder with complex etiology, currently lacks effective therapeutic agents. Natural products (NPs), derived from plants, animals, or microbes, have shown promising effects in PD models through their antioxidative and anti-inflammatory properties, well the enhancement of mitochondrial homeostasis autophagy. The misfolding deposition α-Synuclein (α-Syn), due to abnormal overproduction impaired clearance, being central death dopamine (DA) neurons. Thus, inhibiting α-Syn aggregation has become critical focus discovery. This review highlights NPs that can reduce by preventing its misfolding, emphasizing potential novel drugs adjunctive therapies for treatment, thereby providing further insights clinical translation.
Язык: Английский
Процитировано
0
Food & Nutrition Research, Год журнала: 2024, Номер 68
Опубликована: Ноя. 7, 2024
The escalating global burden of cardiovascular diseases, largely driven by unhealthy lifestyle choices and dietary patterns, has intensified the search for effective safe interventions. With current treatments often marred significant side effects, exploration natural compounds such as flavonoids presents a compelling alternative.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 290, С. 139041 - 139041
Опубликована: Дек. 19, 2024
Язык: Английский
Процитировано
0