Advances in biochemical engineering, biotechnology, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Synthetic biology and engineering, Год журнала: 2025, Номер 3(1), С. 10001 - 10001
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Biotechnology Advances, Год журнала: 2024, Номер 77, С. 108464 - 108464
Опубликована: Окт. 9, 2024
Biotechnology has been built on the foundation of a small handful well characterized and well-engineered organisms. Recent years have seen breakout performer gain attention as new entrant into bioengineering toolbox: Vibrio natriegens. This review covers recent research efforts making V. natriegens biotechnology platform, using large language model (LLM) knowledge graph to expedite literature survey process. Scientists made advancements in pertaining fundamental metabolic characteristics natriegens, development characterization synthetic biology tools, systems analysis modeling, bioproduction engineering, microbial ecology. Each these subcategories relevance future for applications. In this review, we cover offer context impact they may field, highlighting benefits drawbacks organism. From examining research, it appears that is precipice becoming platform bacterium biotechnology.
Язык: Английский
Процитировано
3
Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(4)
Опубликована: Июнь 7, 2024
Abstract Glutamine, the most abundant amino acid in body, plays a critical role preserving immune function, nitrogen balance, intestinal integrity, and resistance to infection. However, its limited solubility instability present challenges for use functional nutrient. Consequently, there is preference utilizing glutamine‐derived peptides as an alternative achieve enhanced functionality. This article aims review applications of glutamine monomers clinical, sports, enteral nutrition. It compares effectiveness provides comprehensive assessment terms their classification, preparation, mechanism absorption, biological activity. Furthermore, this study explores potential integration artificial intelligence (AI)‐based peptidomics synthetic biology de novo design large‐scale production these peptides. The findings reveal that possess significant structure‐related bioactivities, with smaller molecular weight fraction serving primary active ingredient. These ability promote homeostasis, exert hypotensive hypoglycemic effects, display antioxidant properties. our understanding structure–function relationships remains largely exploratory at current stage. combination AI based presents opportunity explore untapped resources food ingredients. Additionally, utilization bioavailability can be through delivery systems vivo. serves valuable reference future investigations developments discovery, validation, biomanufacturing science.
Язык: Английский
Процитировано
3
Enzyme and Microbial Technology, Год журнала: 2024, Номер 176, С. 110412 - 110412
Опубликована: Фев. 15, 2024
Язык: Английский
Процитировано
2
Biotechnology and Bioengineering, Год журнала: 2024, Номер 121(7), С. 2121 - 2132
Опубликована: Апрель 17, 2024
Abstract l ‐glutathione (GSH) is an important tripeptide compound with extensive applications in medicine, food additives, and cosmetics industries. In this work, innovative whole‐cell catalytic strategy was developed to enhance GSH production by combining metabolic engineering of biosynthetic pathways adenosine‐based adenosine triphosphate (ATP) regeneration system Escherichia coli . Concretely, E. , several genes associated ‐cysteine degradation, as well the branched flow, were deleted. Additionally, bifunctional synthase (GshFSA) ATP‐binding cassette exporter (CydDC) overexpressed. Moreover, ATP first introduced into biosynthesis without exogenous additions. Through optimization conditions, engineered strain GSH17‐FDC achieved impressive titer 24.19 g/L only after 2 h reaction, a nearly 100% (98.39%) conversion rate from added ‐Cys. This work not unveils new platform for but also provides valuable insights other high‐value metabolites that rely on consumption.
Язык: Английский
Процитировано
2
Advances in biochemical engineering, biotechnology, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1