Protective and immunomodulatory effects of the novel probiotic yeast Pichia kudriavzevii isolated from a home-made kefir during infection in human colon epithelial cells: An exploratory study
Journal of Functional Foods,
Год журнала:
2025,
Номер
125, С. 106666 - 106666
Опубликована: Янв. 8, 2025
Язык: Английский
Vitamin K2 alleviates dextran sulfate sodium-induced colitis via inflammatory responses, gut barrier integrity, and the gut microbiota in mice
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
280, С. 136091 - 136091
Опубликована: Сен. 30, 2024
Язык: Английский
Candida utilis Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice via NF-κB/MAPK Suppression and Gut Microbiota Modulation
Rongxin Zang,
Zhouliang Liu,
Huihao Wu
и другие.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1993 - 1993
Опубликована: Фев. 25, 2025
Candida
utilis
(CUM)
possesses
various
biological
effects,
including
anti-inflammatory,
intestinal
microbiota
regulatory,
and
immunomodulatory
activities.
However,
there
has
been
little
exploration
regarding
the
effects
of
CUM
on
ulcerative
colitis
(UC).
Therefore,
this
study
aimed
to
investigate
beneficial
alleviating
dextran
sulfate
sodium
(DSS)-induced
UC
in
mice
explore
potential
underlying
mechanisms.
Here,
effect
was
analyzed
using
a
DSS-induced
mouse
model
(n
=
9),
results
which
indicated
decrease
disease
activity
index
(DAI)
mice.
Furthermore,
alleviated
colon
shortening,
minimized
tissue
damage,
preserved
tight
junction
proteins
(Claudin-3,
Occludin,
ZO-1).
reduced
level
pro-inflammatory
cytokines
(IL-1β,
IL-6,
TNF-α),
inhibited
activation
NF-ĸB,
MAPK
PPARγ
signaling
pathways,
decreased
oxidative
mediators
(MPO,
SOD
MDA)
Additionally,
it
mitigated
dysbiosis
by
increasing
abundance
Prevotellaceae
Lactobacillus
while
decreasing
Bacteroidaceae
Enterobacteriaceae.
short-chain
fatty
acids
(SCFAs)
content
The
above
provide
scientific
basis
for
CUM,
as
natural
supplement,
restore
balance
gut
inflammatory
promote
health.
Язык: Английский
Unveiling the Multifaceted Benefits of Simiao Pill in Ulcerative Colitis: Integrative Analysis of Signaling Pathways, Gut Microbiota, and Lipid Metabolism
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119714 - 119714
Опубликована: Март 1, 2025
Язык: Английский
Effect of 1-Kestose on Lipid Metabolism in a High-Fat-Diet Rat Model
Kento Kuramitsu,
Masayoshi Kubo,
Felicia Cindy
и другие.
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1362 - 1362
Опубликована: Апрель 16, 2025
Objectives:
Hyperlipidemia
is
a
risk
factor
for
various
diseases.
Identifying
food
components
that
can
help
reduce
the
levels
of
blood
lipids,
such
as
cholesterol
and
triglycerides,
global
research
priority.
It
has
been
reported
1-Kestose,
fructooligosaccharide,
triglyceride
in
rats;
however,
underlying
mechanisms
remain
unclear.
Therefore,
we
aimed
to
elucidate
effects
1-kestose
supplementation
on
lipid
metabolism
gut
environment
rats.
Methods:
Twenty
male
Sprague–Dawley
rats
(age
8
weeks)
were
provided
1-kestose-containing
water
maintained
two
weeks.
After
dissection,
components,
hepatic
gene
expression,
microbiota,
bile
acid
composition
cecal
contents
analyzed.
Results:
The
1-Kestose
intake
reduced
plasma
levels.
Additionally,
an
increase
cytochrome
P450
family
7
subfamily
A
member
1
mRNA
key
synthesis
liver,
decrease
synthesis-related
expression
observed.
In
cecum,
deconjugated
acids,
which
are
involved
regulation
synthesis,
increased.
Furthermore,
altered
microbiota
leading
abundance
specific
bacteria,
Bifidobacterium,
deconjugation
conjugated
acids.
Conclusions:
alters
potentially
influencing
host.
Язык: Английский
Harnessing Probiotics: Emerging Strategies for Health and Disease Management
Indian Journal of Microbiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
Язык: Английский
OVA-Induced Food Allergy Leads to Neurobehavioral Changes in Mice and the Potential Role of Gut Microbiota and Metabolites Dysbiosis
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(10), С. 4760 - 4760
Опубликована: Май 16, 2025
The
neurobehavioral
changes
in
food
allergy
mice
have
not
been
comprehensively
studied,
and
the
mechanism
underlying
them
remains
unclear.
Our
study
aims
to
fully
investigate
OVA
(ovalbumin)-sensitized
explore
potential
via
gut
microbiota-brain
axis.
We
established
mouse
(C57BL/6J
male)
model
with
OVA,
evaluating
anaphylactic
symptoms
levels
of
Th2
signature
cytokine
allergy-related
antibodies
serum.
Using
behavioral
tests,
we
measured
anxiety,
depression,
social
behavior,
repetitive
attention,
spatial
memory
control
mice.
In
addition,
analyzed
prefrontal
cortex
for
measuring
inflammation-related
indicators
gathered
serum
untargeted
metabolomics
analysis
feces
16S
rDNA
sequencing.
exhibited
significantly
elevated
IgE
levels.
addition
anxiety-like,
depression-like,
behaviors,
also
displayed
less
interest
damaged
attention.
TNF-α,
IL-1β,
IL-6
activation
microglia
were
increased,
which
might
explain
neuronal
damage.
multi-omics
technology,
amino
acid
metabolism
disruption,
particularly
carboxylic
acids
derivatives,
was
observed
mice,
remarkably
correlated
altered
abundance
microbiota
related
allergy.
Behaviors
OVA-induced
extensively
impaired.
disruption
associated
dysbiosis
play
a
pivotal
role
impairing
neural
immune
homeostasis
damage,
could
be
responsible
abnormalities.
Язык: Английский
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 7, 2024
Acute
graft-versus-host
disease
(aGVHD)
is
primarily
driven
by
allogeneic
donor
T
cells
associated
with
an
altered
composition
of
the
host
gut
microbiome
and
its
metabolites.
The
severity
aGVHD
after
hematopoietic
stem
cell
transplantation
(allo-HSCT)
not
solely
determined
characteristics;
however,
underlying
mechanisms
remain
unclear.
Using
single-cell
RNA
sequencing,
we
decoded
immune
atlas
12
patients
who
underwent
allo-HSCT:
six
non-aGVHD.
We
performed
a
fecal
microbiota
(16SrRNA
sequencing)
analysis
to
investigate
bacterial
82
patients:
30
52
Fecal
samples
from
these
were
analyzed
for
bile
acid
metabolism.
Through
multi-omic
analysis,
identified
feedback
loop
involving
"immune
cell-gut
microbes-bile
metabolites"
contributing
heightened
responses
in
aGVHD.
dysbiosis
disruption
metabolism
contributed
exaggerated
interleukin-1
mediated
response.
Our
findings
suggest
that
resistin
defensins
are
crucial
mitigating
against
Therefore,
comprehensive
incorporating
cells,
microbes,
metabolites
was
developed
this
study
used
propose
novel,
non-immunosuppressive
approaches
prevent
Язык: Английский
Potential of Fiber and Probiotics to Fight Against the Effects of PhIP + DSS-Induced Carcinogenic Process of the Large Intestine
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(45), С. 25161 - 25172
Опубликована: Окт. 29, 2024
We
determined
the
in
vivo
counteracting
effect
of
fiber
and
probiotic
supplementation
on
colonic
mucosal
damage
alterations
gut
microbiota
caused
by
2-amino-1-methyl-6-phenylimidazo
[4,5-b]
pyridine
(PhIP)
sodium
dextran
sulfate
(DSS).
Male
Fischer-344
rats
were
randomly
divided
into
4
groups:
control
(standard
diet),
PhIP
+
DSS
group
diet
DSS),
(fiber
(probiotic
DSS).
The
intake
for
3
weeks
induced
erosion,
crypt
loss,
inflammation,
distal
colon
was
more
severely
damaged.
Fiber
alleviated
reducing
loss
while
increased
length.
fecal
relative
abundance
Clostridia
UCG014
along
intervention,
contrast
to
lower
abundances
these
taxa
found
after
administration
supplemented
with
probiotics
or
fiber.
mitigated
histological
shifting
toward
a
reduction
pro-inflammatory
taxa.
Язык: Английский
Integrated multi-omics analysis of the microbial profile characteristics associated with pulmonary arterial hypertension in congenital heart disease
Microbiology Spectrum,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
ABSTRACT
Dysregulation
of
immune
and
inflammatory
cells
around
blood
vessels
metabolic
dysfunction
are
key
mechanisms
in
the
development
pulmonary
arterial
hypertension
(PAH).
The
homeostasis
human
microbiome
plays
a
crucial
role
regulating
responses
progression
diseases.
For
associated
with
congenital
heart
disease
involving
body-lung
shunt
(PAH-CHD),
potential
impact
on
“gut-lung
axis”
remains
underexplored.
This
study
recruited
15
healthy
individuals
patients
due
to
from
Fuwai
Yunnan
Hospital,
Chinese
Academy
Medical
Sciences,
Kunming
Children's
Hospital.
We
performed
differential
analyses
metabolites
microbiota
both
gut
lower
respiratory
tract
for
these
two
groups.
goal
was
investigate
metabolome
profiles
children
PAH-CHD
analyze
interrelationships
between
profiles.
Ultimately,
we
aim
propose
value
aiding
diagnosis.
results
indicated
that
characterized
by
an
increased
abundance
beneficial
symbionts,
which
closely
linked
changes
metabolome.
Metabolite
functional
enrichment
analysis
revealed
energy
metabolism
reprogramming
group,
active
pathways
bile
acid
secretion
carnitine
homeostasis.
Moreover,
expression
correlated
right
function
growth
development.
IMPORTANCE
Previous
studies
have
primarily
focused
relationship
PAH.
However,
microbial
perspective
gut-lung
axis
has
not
been
adequately
elucidated.
Our
utilizes
integrated
multi-omics
approach
report
characteristics
lung
reference
subjects.
found
influence
pathological
manifestations
through
their
activity.
Additionally,
alterations
ecological
structure.
findings
suggest
modulating
composition
may
positive
implications
maintaining
environment
PAH-CHD.
Язык: Английский