Evaluation of Phenazine Derivatives from the Lichen-Associated Streptomyces flavidovirens as Potent Antineuroinflammatory Agents In Vitro and In Vivo

Journal of Natural Products, Год журнала: 2024, Номер 87(8), С. 1930 - 1940

Опубликована: Авг. 14, 2024

Eighteen nitrogen-containing compounds (

Язык: Английский

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A one-pot synthesized dual-emission MOFs-based ratiometric fluorescent sensor for hypersensitive and portable detection of griseofulvin

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137613 - 137613

Опубликована: Март 1, 2025

Язык: Английский

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Isoflavones and Stilbenes With Antifungal Activities From the Seeds of Thermopsis lanceolata R. Br

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 30, 2025

In order to discover novel fungicides from natural products, the phytochemical investigation of Thermopsis lanceolata seeds was thoroughly conducted. Eight new isoflavone derivatives (1-5 and 8-10), two stilbenes (6 7), as well 21 known isoflavones (11-31) were obtained crude extract T. following a bioassay-guided method. The structures 1-31 confirmed via HRESIMS, NMR, IR, UV, quantum chemistry calculations. antifungal activities against Phytophthora nicotiana, Colletotrichum orbiculare, Rhizoctonia solani, Botrytis cinerea screened according mycelial inhibition test. Compound 6 displayed significant activity B. in vitro (EC50: 9.68 μg/mL) had an 8 5.7% prevention control effect vivo (100 μg/mL). Moreover, mechanism studies revealed that causes accumulation reactive oxygen species, increases level lipid peroxidation, decreases MDH, finally triggers molecular damage cell death vitro. Therefore, can be utilized lead compound for fungicides.

Язык: Английский

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Design and synthesis of novel cinnamamide derivatives‐based lansiumamide B as potent fungicidal candidates

Pest Management Science, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

Abstract BACKGROUND Natural products have been and continue to be a significant resource for developing environmentally friendly pesticides with distinctive structures mechanisms. Lansiumamide B (LB), cinnamamide compound extracted from Clausena lansium seeds, has served as the lead design synthesis of series derivatives. The fungicidal activity these derivatives evaluated. RESULTS majority proposed compounds displayed moderate considerable antifungal efficacy against tested pathogenic fungi oomycetes, some exhibiting broad‐spectrum activities. Compound 26 showed excellent Colletotrichum orbiculare in vitro , median effective concentration (EC 50 ) value 0.36 μg/mL, better than positive control boscalid (0.95 μg/mL) LB (60.18 μg/mL). In vivo also exhibited greater C. LB. Furthermore, study found that mycelium cell wall was damaged after treatment through observation mycelial morphology ultrastructure . Consequently, growth inhibited. CONCLUSION results indicated containing 1,2,3,4‐tetrahydroisoquinoline moiety represent novel class active scaffold, potential developed into new type fungicide. © 2025 Society Chemical Industry.

Язык: Английский

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Naphthoquinone Derivatives from the Endophytic Fungus Fusarium solani Induce Pancreatic Cancer Cells Apoptosis via Targeting EGFR-Mediated PI3K/Akt Pathway

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(47), С. 26209 - 26223

Опубликована: Ноя. 13, 2024

Seven new polyketide compounds, four naphthoquinone derivatives, neofusarubins A-D (

Язык: Английский

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Synthesis and Antifungal Activity Evaluation of Novel L-Carvone-Based 1,3,4-Thiadiazole-amide Derivatives as a Potential Succinate Dehydrogenase Inhibitor

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(47), С. 26116 - 26124

Опубликована: Ноя. 14, 2024

In an effort to explore new-type high-efficiency antifungal agents, 25 novel

Язык: Английский

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Discovery of New Antifungal Polyketides Cladrioides A–N against Phytopathogenic Fungi from Cladosporium cladosporioides LD-8

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

During the search for natural fungicides, 14 new australifungin analogues cladrioides A–S (1–14) and two known ones (15 16) were obtained from Cladosporium cladosporioides LD-8. Their structures elucidated by comprehensive analysis of NMR HRESIMS data, as well ECD calculations. Compounds 1 2 possess a novel 6/6/5-fused tricyclic scaffold. Most compounds exhibited remarkable antifungal activities against tested phytopathogenic fungi. Among them, 7, 10, 16 showed excellent with IC50 values ranging 1.71 to 16.63 μg/mL. inhibitory A. brassicicola alternata higher than that commercial fungicide hymexazol. Compound displayed potent in vivo activity solani at 100 μg/mL an rate 96.82%. The structure–activity relationship was analyzed first time. Therefore, our study provides promising candidates development fungicides plant protection.

Язык: Английский

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Design, synthesis, and antifungal activity of hydrazone Schiff bases containing cinnamaldehyde moieties

Phytochemistry Letters, Год журнала: 2024, Номер 65, С. 53 - 57

Опубликована: Дек. 3, 2024

Язык: Английский

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