Isoflavones and Stilbenes With Antifungal Activities From the Seeds of Thermopsis lanceolata R. Br

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

In order to discover novel fungicides from natural products, the phytochemical investigation of Thermopsis lanceolata seeds was thoroughly conducted. Eight new isoflavone derivatives (1-5 and 8-10), two stilbenes (6 7), as well 21 known isoflavones (11-31) were obtained crude extract T. following a bioassay-guided method. The structures 1-31 confirmed via HRESIMS, NMR, IR, UV, quantum chemistry calculations. antifungal activities against Phytophthora nicotiana, Colletotrichum orbiculare, Rhizoctonia solani, Botrytis cinerea screened according mycelial inhibition test. Compound 6 displayed significant activity B. in vitro (EC50: 9.68 μg/mL) had an 8 5.7% prevention control effect vivo (100 μg/mL). Moreover, mechanism studies revealed that causes accumulation reactive oxygen species, increases level lipid peroxidation, decreases MDH, finally triggers molecular damage cell death vitro. Therefore, can be utilized lead compound for fungicides.

Language: Английский

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Evaluation of Phenazine Derivatives from the Lichen-Associated Streptomyces flavidovirens as Potent Antineuroinflammatory Agents In Vitro and In Vivo

Journal of Natural Products, Journal Year: 2024, Volume and Issue: 87(8), P. 1930 - 1940

Published: Aug. 14, 2024

Eighteen nitrogen-containing compounds (

Language: Английский

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A one-pot synthesized dual-emission MOFs-based ratiometric fluorescent sensor for hypersensitive and portable detection of griseofulvin

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137613 - 137613

Published: March 1, 2025

Language: Английский

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Synthesis and Antifungal Activity Evaluation of Novel L-Carvone-Based 1,3,4-Thiadiazole-amide Derivatives as a Potential Succinate Dehydrogenase Inhibitor

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(47), P. 26116 - 26124

Published: Nov. 14, 2024

In an effort to explore new-type high-efficiency antifungal agents, 25 novel

Language: Английский

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Naphthoquinone Derivatives from the Endophytic Fungus Fusarium solani Induce Pancreatic Cancer Cells Apoptosis via Targeting EGFR-Mediated PI3K/Akt Pathway

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(47), P. 26209 - 26223

Published: Nov. 13, 2024

Seven new polyketide compounds, four naphthoquinone derivatives, neofusarubins A-D (

Language: Английский

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Discovery of New Antifungal Polyketides Cladrioides A–N against Phytopathogenic Fungi from Cladosporium cladosporioides LD-8

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

During the search for natural fungicides, 14 new australifungin analogues cladrioides A–S (1–14) and two known ones (15 16) were obtained from Cladosporium cladosporioides LD-8. Their structures elucidated by comprehensive analysis of NMR HRESIMS data, as well ECD calculations. Compounds 1 2 possess a novel 6/6/5-fused tricyclic scaffold. Most compounds exhibited remarkable antifungal activities against tested phytopathogenic fungi. Among them, 7, 10, 16 showed excellent with IC50 values ranging 1.71 to 16.63 μg/mL. inhibitory A. brassicicola alternata higher than that commercial fungicide hymexazol. Compound displayed potent in vivo activity solani at 100 μg/mL an rate 96.82%. The structure–activity relationship was analyzed first time. Therefore, our study provides promising candidates development fungicides plant protection.

Language: Английский

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Design, synthesis, and antifungal activity of hydrazone Schiff bases containing cinnamaldehyde moieties

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 65, P. 53 - 57

Published: Dec. 3, 2024

Language: Английский

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