Transforming monosaccharides: recent advances in rare sugar production and future exploration

BBA Advances, Год журнала: 2025, Номер 7, С. 100143 - 100143

Опубликована: Янв. 1, 2025

Язык: Английский

---

Biochemical characterization and biocatalytic application of a hyperthermostable tagatose 4-epimerase from Infirmifilum uzonense

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 305, С. 141168 - 141168

Опубликована: Фев. 17, 2025

Язык: Английский

---

High-Temperature Catalytic Platform Powered by Thermophilic Microorganisms and Thermozymes

Synthetic biology and engineering, Год журнала: 2025, Номер 3(1), С. 10001 - 10001

Опубликована: Янв. 1, 2025

Язык: Английский

---

Discovery, design, and engineering of enzymes based on molecular retrobiosynthesis

mLife, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Abstract Biosynthesis—a process utilizing biological systems to synthesize chemical compounds—has emerged as a revolutionary solution 21st‐century challenges due its environmental sustainability, scalability, and high stereoselectivity regioselectivity. Recent advancements in artificial intelligence (AI) are accelerating biosynthesis by enabling intelligent design, construction, optimization of enzymatic reactions systems. We first introduce the molecular retrosynthesis route planning biochemical pathway including single‐step algorithms AI‐based design tools. highlight advantages large language models addressing sparsity data. Furthermore, we review enzyme discovery methods based on sequence structure alignment techniques. Breakthroughs structural prediction expected significantly improve accuracy discovery. also summarize for de novo generation nonnatural or orphan reactions, focusing functional annotation techniques reaction small molecule similarity. Turning engineering, discuss strategies thermostability, solubility, activity, well applications AI these fields. The shift from traditional experiment‐driven data‐driven computationally driven is already underway. Finally, present potential provide perspective future research directions. envision expanded biocatalysis drug development, green chemistry, complex synthesis.

Язык: Английский

---

The use of isomerases and epimerases for the production of the functional sugars mannose, allulose and tagatose from Fructose

World Journal of Microbiology and Biotechnology, Год журнала: 2025, Номер 41(4)

Опубликована: Апрель 1, 2025

Язык: Английский

---

Enhanced thermostability and catalytic activity for arginine deiminase from Enterobacter faecalis SK32.001 via combinatorial mutagenesis

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138004 - 138004

Опубликована: Ноя. 1, 2024

Язык: Английский

---