Protective mechanism of quercetin nanoliposomes on hydrogen peroxide-induced oxidative damage in 3D Caco-2 cell model DOI Creative Commons
Xiaofeng Liu, Zhiyuan Zhou, Xiaoqin Lu

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106650 - 106650

Published: Dec. 26, 2024

Language: Английский

A brain-targeted and ROS-responsive natural polysaccharide nanogel for enhancing antidepressant therapy DOI
Dong Xu,

Tao Qiao,

Yan-Ming Zhou

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160719 - 160719

Published: Feb. 1, 2025

Language: Английский

Citations

1
Key Targets of Brain-Gut Coordination in Wuzhuyu Decoction Treating Chronic Migraine Based on Proteomics DOI
Meijing Li,

Zhimin Song,

Kristine Wang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review DOI Creative Commons

Andreea Sălcudean,

Cristina-Raluca Bodo,

Ramona Amina Popovici

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 502 - 502

Published: March 30, 2025

Depression is a multifactorial psychiatric condition with complex pathophysiology, increasingly linked to neuroinflammatory processes. The present review explores the role of neuroinflammation in depression, focusing on glial cell activation, cytokine signaling, blood-brain barrier dysfunction, and disruptions neurotransmitter systems. article highlights how inflammatory mediators influence brain regions implicated mood regulation, such as hippocampus, amygdala, prefrontal cortex. further discusses involvement hypothalamic-pituitary-adrenal (HPA) axis, oxidative stress, kynurenine pathway, providing mechanistic insights into chronic inflammation may underlie emotional cognitive symptoms depression. bidirectional relationship between depressive emphasized, along peripheral immune responses systemic stress. By integrating molecular, cellular, neuroendocrine perspectives, this supports growing field immunopsychiatry lays foundation for novel diagnostic biomarkers anti-inflammatory treatment approaches Further research holds promise developing more effective personalized interventions individuals suffering from

Language: Английский

Citations

0
Ginsenoside Re Inhibits NLRP3 Inflammasome Activation in Depressive Mice by Promoting PINK1-Mediated Mitophagy DOI
Shan Liu, Yue Zhang, Hao Zhou

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Ginsenoside Re (Re) was proved effective in improving depressive-like behaviors. However, the potential antidepressant mechanism of remains unrevealed. In this study, we investigated whether PINK1-mediated mitophagy and NLRP3 inflammasomes were linked to chronic unpredictable mild stress (CUMS) mice lipopolysaccharide (LPS)-stimulated astrocytes. RNA sequencing bioinformatics analyses performed discover targets pathways associated with Re. PTEN-induced putative kinase 1 (PINK1) knockdown conducted clarify role The outcomes showed that ameliorated behaviors, activated mitophagy, inhibited inflammasome activation. PINK1 attenuated effect promotion decline activation caused by reversed knockdown. conclusion, promoting exert its effect.

Language: Английский

Citations

0
Protective mechanism of quercetin nanoliposomes on hydrogen peroxide-induced oxidative damage in 3D Caco-2 cell model DOI Creative Commons
Xiaofeng Liu, Zhiyuan Zhou, Xiaoqin Lu

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106650 - 106650

Published: Dec. 26, 2024

Language: Английский

Citations

0