Synthetic Communications,
Год журнала:
2020,
Номер
50(22), С. 3443 - 3461
Опубликована: Авг. 9, 2020
The
present
paper
elicits
a
marvelous
synthesis
of
series
sulfonamide
containing
1,4-disubstituted
1,2,3-triazoles
through
click
reaction
terminal
alkynes
with
aromatic
azides.
synthesized
triazoles
were
characterized
by
FTIR,
1H
NMR,13C
NMR
and
HRMS
techniques.
Further,
the
structures
compounds
6u
(CCDC
1954932)
6z3
1954931)
also
confirmed
X-ray
crystallography.
evaluated
for
in
vitro
antibacterial
activity
against
S.
aureus,
B.subtilis,
E.
coli
K.
pneumoniae
serial
dilution
method.
Among
series,
compound
4-bromo-N-(2-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)benzenesulfonamide,
6z4
(MIC
=
0.025
µM/mL)
4-bromo-N-(2-(1-(naphthalen-1-yl)-1H-1,2,3-triazol-4-yl)propan-2-yl)benzenesulfonamide
6z6
0.027
exhibited
appreciable
Staphylococcus
aureus
Bacillus
subtilis.
molecular
docking
studies
above
potent
analogs
dihydropteroate
synthase
was
performed
to
have
an
insight
binding
interactions.
Synthesized
molecules
explored
antioxidant
activity,
reflecting
6m
as
better
radical
scavenging
agent
IC50
value
1.96
µM/mL.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 10, 2023
Phytopathogen,
pest,
weed,
and
nutrient
deficiency
cause
severe
losses
to
global
crop
yields
every
year.
As
the
core
engine,
agrochemicals
drive
continuous
development
of
modern
agriculture
meet
demand
for
agricultural
productivity
increase
environmental
burden
due
inefficient
use.
With
new
advances
in
nanotechnology,
introducing
nanomaterials
into
realize
agrochemical
accurate
targeted
delivery
has
brought
opportunities
support
sustainable
green
agriculture.
Metal–Organic
frameworks
(MOFs),
which
weave
metal
ions/clusters
organic
ligands
porous
frameworks,
have
exhibited
significant
advantages
constructing
biotic/abiotic
stimuli-responsive
nanoplatforms
controlled
delivery.
This
review
emphasizes
recent
developments
MOF-based
protection,
including
phytopathogen,
weed
control,
growth
promotion,
fertilizer/plant
hormone
Finally,
forward-looking
perspectives
challenges
on
future
applications
protection
promotion
are
also
discussed.
Journal of Agricultural and Food Chemistry,
Год журнала:
2022,
Номер
70(30), С. 9262 - 9275
Опубликована: Июль 21, 2022
The
introduction
of
active
groups
natural
products
into
the
framework
pesticide
molecules
is
an
effective
approach
for
discovering
lead
compounds,
and
thus
has
been
widely
used
in
development
new
agrochemicals.
In
this
work,
a
novel
series
1,2,3,4-tetrahydroquinoline
derivatives
containing
pyrimidine
ether
scaffold
were
designed
synthesized
by
substructure
splicing
method.
compounds
showed
good
antifungal
activities
against
several
fungi.
Especially,
compound
4fh
displayed
excellent
vitro
activity
Valsa
mali
Sclerotinia
sclerotiorum
with
EC50
values
0.71
2.47
μg/mL,
respectively.
had
slightly
stronger
inhibitory
(68.08%
at
50
μM)
chitin
synthase
(CHS)
than
that
polyoxin
D
(63.84%
exhibited
obvious
curative
protective
effects
on
S.
sclerotiorumin
vivo.
Thus,
can
be
considered
as
candidate
fungicide
inhibitor.
An
accurate
reliable
three-dimensional
quantitative
structure-activity
relationship
(3D-QSAR)
model
presented
useful
direction
further
excogitation
more
highly
fungicides.
Molecular
docking
revealed
conventional
hydrogen
bond
mainly
affected
binding
affinity
synthase.
present
results
will
provide
guidance
to
discover
potential
CHS-based
fungicides
plant
disease
control
agriculture.
Journal of Agricultural and Food Chemistry,
Год журнала:
2021,
Номер
69(8), С. 2382 - 2391
Опубликована: Фев. 19, 2021
Considering
the
severity
of
plant
pathogen
resistance
toward
commonly
used
agricultural
microbicides,
as
well
potential
threats
agrichemicals
to
eco-environment,
there
is
a
pressing
need
for
antimicrobial
approaches
that
are
capable
inactivating
pathogens
efficiently
without
risk
inducing
resistances
and
harm.
In
this
work,
porphyrin
metal–organic
framework
(MOF)
nanocomposite
was
constructed
by
incorporating
5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin
tetra(p-toluenesulfonate)
(TMPyP)
photosensitizer
(PS)
in
cage
variant
MOF
(HKUST-1)
produce
singlet
oxygen
(1O2)
inactivate
under
light
irradiation.
The
results
showed
prepared
PS@MOF
had
loading
rate
PS
about
12%
(w/w)
excellent
broad-spectrum
photodynamic
activity
vitro
against
three
pathogenic
fungi
two
bacteria.
Moreover,
outstanding
control
efficacy
Sclerotinia
sclerotiorum
on
cucumber
pot
experiment.
Allium
cepa
chromosome
aberration
assays
safety
evaluation
Chinese
cabbage
indicated
no
genotoxicity
safe
plants.
Thus,
demonstrated
great
an
alternative
efficient
new
microbicide
sustainable
disease
management.
ACS Omega,
Год журнала:
2020,
Номер
5(35), С. 22596 - 22602
Опубликована: Авг. 26, 2020
Tobacco
mosaic
virus
coat
protein
(TMV
CP)
plays
an
important
role
in
viral
replication,
translation,
and
intracellular
intercellular
movements.
Thus,
TMV
CP
could
be
regarded
as
a
potential
target
for
antiviral
agents.
In
this
study,
order
to
find
out
whether
dithioacetal
derivatives
act
on
the
target,
series
of
containing
sulfonamide
moiety
was
first
designed
synthesized.
Bioassay
results
demonstrated
that
Y14,
Y18,
Y21
exhibited
excellent
activities
against
TMV,
with
half-maximal
effective
concentrations
(EC50)
curative,
protective,
inactivate
being
183.0
±
3.2,
252.3
2.6,
63.8
1.2
μg/mL,
270.6
3.7,
249.7
3.5,
57.7
1.4
329.5
1.5,
269.2
48.1
2.0
μg/mL
Y21,
respectively,
which
were
higher
than
those
control
agents
ningnanmycin
(331.0
2.8,
271.0
77.4
1.3
respectively)
d2
(471.5
1.4,
447.2
2.1,
91.7
1.8
respectively).
Transmission
electron
microscopy
showed
particle
morphology
destroyed
by
microscale
thermophoresis
(MST)
bonded
dissociation
constant
(Kd)
9.7
1.7
μM.
Then,
molecular
docking
MST
further
illustrated
had
weak
binding
affinity
mutant
(Kd
=
561.3
83.2
μM).
we
deduced
derivative
may
inhibit
activity
CP.
This
work
provides
some
new
insights
design
optimization
novel
anti-TMV
