Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Язык: Английский

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Photocatalytic Thio/Selenosulfonylation–Bicyclization of Indole-Tethered 1,6-Enynes Leading to Substituted Benzo[c]pyrrolo[1,2,3-lm]carbazoles

Organic Letters, Год журнала: 2024, Номер 26(18), С. 3828 - 3833

Опубликована: Апрель 29, 2024

The photocatalyzed radical-triggered thio/selenosulfonylation–bicyclization of indole-tethered 1,6-enynes has been established for the first time, enabling synthesis various previously unreported thio/selenosulfonylated benzo[c]pyrrolo[1,2,3-lm]carbazoles with moderate to good yields under mild conditions. reaction pathway was proposed, consisting energy transfer, homolytic cleavage, radical addition, 5-exo-dig, coupling, and a Mallory cascade. This approach exhibits wide substrate compatibility excellent tolerability toward functional groups is characterized by its remarkable efficiency in both bond formation annulation.

Язык: Английский

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Benzannulation of Functionally Enhanced Indole-3-carbaldehydes with Ynones and Alkynoates: A Domino Approach to Bioactive Carbazoles─Synthesis of Clauolenzole A, Calothrixin A & B, Methyl Carbazole-3-carboxylate, and Quinocarbazole

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

A flexible, regioselective, benzannulation strategy toward multifunctional carbazoles from 2-(2-oxo-2-arylethyl)indole-3-carbaldehydes, employing either ynones or alkynoates as reaction partners, has been envisaged and implemented. This enabling access to variegated in one-flask operation leads strategic substituent diversification via partner variation. The efficacy applications of this methodology are demonstrated through 23 examples concise syntheses bioactive clauolenzole A, calothrixin & B, methyl carbazole-3-carboxylate, pharmacophoric quinocarbazole.

Язык: Английский

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New 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one derivatives as antimicrobial and anti-cancer agents: Synthesis, in-vitro and SAR studies

Journal of Molecular Structure, Год журнала: 2023, Номер 1294, С. 136516 - 136516

Опубликована: Авг. 30, 2023

Язык: Английский

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N-heterocyclic carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp³)–H acylation

Green Chemistry, Год журнала: 2024, Номер 26(9), С. 5397 - 5408

Опубликована: Янв. 1, 2024

Carbene and photocatalyst-catalyzed rapid access to indole ketones via radical C(sp 3 )–H acylation.

Язык: Английский

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Diverse pharmacological actions of potential carbazole derivatives by influencing various pathways of molecular signaling

Future Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 10(1)

Опубликована: Июнь 17, 2024

Abstract Background Carbazoles are an important class of heterocyclic aromatic compounds that contain nitrogen atom in the ring. They have a large-conjugated system, attractive “electrical and charge-transport properties”, ability to efficiently incorporate different functional groups into structurally inflexible carbazolyl Main text Carbazole derivative ECCA acts as anticancer agent by reactivating P53 molecular signaling pathway; similarly, some other derivatives carbazole show antifungal activity acting on RAS-MAPK pathway. also their effect inflammation inhibiting p38 mitogen-activated protein kinase pathway stopping conversion DAXX ASK-1. By modifying AKT through boosting phosphatase brain, they anti-Alzheimer’s translocating GLUT4 these effective against diabetes. Conclusion After exploring literature carbazole, it was found has immeasurably great potential for treatment various diseases nucleus leads synthesized which used pharmacological activities. So there is need explore newer drugs.

Язык: Английский

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Novel carbazolyl–thiazolyl–chromone and carbazolyl–thiazolyl–pyrazole hybrids: synthesis, cytotoxicity evaluation and molecular docking studies

RSC Advances, Год журнала: 2024, Номер 14(24), С. 17245 - 17260

Опубликована: Янв. 1, 2024

A simple synthetic method was performed to design a novel series of polycyclic systems consisting carbazole–thiazolidinone–chromone hybrids 4a–e and carbazole–thiazolidinone–pyrazole 5a–e in excellent yields.

Язык: Английский

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The therapeutic potential of indole hybrids, dimers, and trimers against drug‐resistant ESKAPE pathogens

Archiv der Pharmazie, Год журнала: 2024, Номер 357(10)

Опубликована: Июнь 26, 2024

Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter (ESKAPE) species as causative agents are characterized by increased levels of resistance toward multiple classes first-line well last-resort antibiotics represent serious global health concerns, creating a critical need for the development novel antibacterials with therapeutic potential against drug-resistant ESKAPE species. Indole derivatives structural mechanistic diversity demonstrated broad-spectrum antibacterial activity various clinically important pathogens including ESKAPE. Moreover, several indole-based that exemplified creatmycin have already been used in clinics or under clinical trials treatment bacterial infections, demonstrating indole hold great promise antibacterials. This review is an endeavor to highlight current scenario hybrids, dimers, trimers pathogens, covering articles published from 2020 present, open new avenues exploration antidrug-resistant candidates.

Язык: Английский

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Preliminary study on the effects of dry powder and water extract of Neolamarckia cadamba on growth performance, immunity, and intestinal health of yellow-feathered broilers

BMC Veterinary Research, Год журнала: 2025, Номер 21(1)

Опубликована: Апрель 2, 2025

In recent years, the livestock industry has shown increasing concern regarding need to find effective alternatives antibiotic products while also striving produce high-quality and poultry products. Woody feed sources exhibit wide distribution variety, containing a variety of bioactive substances such as flavonoids alkaloids. Among these woody plants, Neolamarckia cadamba (Nc) characteristics high leaf yield, fast growth rate, rich nutritional value, which great development potential. However, whether Nc supplementation can improve performance, immunity, gut health yellow-feathered broilers remains be explored. present study, we aimed investigate effects diet supplemented with dry powder or water extract on intestinal broilers. The results showed that, (1) There was no significant difference in Body weight (BW), Average daily gain (ADG), intake (ADFI), Feed conversion ratio (FCR) between experimental groups control group (P > 0.05); (2) Compared group, thymus index at 63 days significantly increased 1% < 0.05). Conversely, bursa Fabricius decreased 0.05) same group; (3) there were differences serum levels albumin (ALB), globulin (GLB), total protein (TP), alanine aminotransferase (ALT), aspartate (AST), triglycerides (TG) each (4) IgG both 0.05% (5) could increase mRNA expression ZO-1 TGF-β4 jejunum, well claudin-1, ZO-1, ileum(P Furthermore, use resulted jejunum ileum These suggest that dietary enhance immune function, small barrier integrity, reduce inflammation certain extent. four doses (1% powder, 2% 0.1% extract), more effective. findings underscore importance exploring alternative additives production, they may offer viable strategy for promoting animal performance absence traditional antibiotics.

Язык: Английский

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Synthesis of Functionalized 4-Hydroxy Carbazoles and Carbazole Alkaloids via Ring Expansion of Indole Cyclopentanone

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 8845 - 8850

Опубликована: Май 30, 2024

The exploration of a ring expansion reaction from indole cyclopentanone to generate range diversely functionalized 4-hydroxyl carbazole frameworks, representing the core structure numerous alkaloids, has been conducted under mild conditions. This approach exhibits broad functional group tolerance and moderate good yields. practical applicability this strategy demonstrated through concise syntheses carbazomycins A, D, G.

Язык: Английский

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