Computational intelligence modeling and optimization of small molecule API solubility in supercritical solvent for production of drug nanoparticles DOI Creative Commons
Jiaxin Liang, H. Vicky Zhao, Shengxue Zhou

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 28, 2025

Язык: Английский

Study of Baclofen Solubility in Supercritical CO2 with and without Cosolvents: Experimental Analysis, Thermodynamic Evaluation, and Machine Learning Methods DOI
Mohammad Ahmar Khan,

P. J. RODRIGUES,

Sameer A. Awad

и другие.

Journal of Chemical & Engineering Data, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

This study investigates the solubility of Baclofen in supercritical CO2, which is essential for developing an efficient drug delivery system using processes. Solubility measurements were carried out both with and without presence various cosolvents (ethanol dimethyl sulfoxide (DMSO)), across a temperature range 308–338 K pressure 12–30 MPa. exhibited ranging from 1.62 × 10–5 to 2.30 mole fractions pure CO2. In cosolvents, increased 5.76 12.79 ethanol 3.50 7.02 DMSO. Indeed, addition DMSO by approximately 3.55–5.56 times 2.15–3.05 times, respectively. Several density-based empirical models thermodynamic (Soave–Redlich–Kwong (SRK) Peng–Robinson (PR) equations state) used correlate data. Jafari Nejad's model CO2–Baclofen Jouyban's CO2–ethanol/DMSO–Baclofen systems displayed higher consistency. Also, PR showed better accuracy correlating while SRK outperformed CO2–ethanol/DMSO cosolvents. Moreover, machine learning exceptional accuracy, over 99% predictions closely matching experimental data, emphasizing its outstanding performance.

Язык: Английский

Процитировано

1
Mechanistic Insights into Amorphous Solid Dispersions: Bridging Theory and Practice in Drug Delivery DOI

B Srividya,

Animesh Ghosh

Pharmaceutical Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

1
Comprehensive study of medications solubility in supercritical CO2 with and without co-solvent; Laboratory, theoretical, and intelligent approaches DOI
Chou‐Yi Hsu, Dheyaa J. Jasim, Pooja Bansal

и другие.

Journal of Molecular Liquids, Год журнала: 2024, Номер 411, С. 125765 - 125765

Опубликована: Авг. 13, 2024

Язык: Английский

Процитировано

3
Computational intelligence modeling and optimization of small molecule API solubility in supercritical solvent for production of drug nanoparticles DOI Creative Commons
Jiaxin Liang, H. Vicky Zhao, Shengxue Zhou

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 28, 2025

Язык: Английский

Процитировано

0