Computational intelligence modeling and optimization of small molecule API solubility in supercritical solvent for production of drug nanoparticles DOI Creative Commons
Jiaxin Liang, H. Vicky Zhao, Shengxue Zhou

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 28, 2025

Language: Английский

Study of Baclofen Solubility in Supercritical CO2 with and without Cosolvents: Experimental Analysis, Thermodynamic Evaluation, and Machine Learning Methods DOI
Mohammad Ahmar Khan,

P. J. RODRIGUES,

Sameer A. Awad

et al.

Journal of Chemical & Engineering Data, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

This study investigates the solubility of Baclofen in supercritical CO2, which is essential for developing an efficient drug delivery system using processes. Solubility measurements were carried out both with and without presence various cosolvents (ethanol dimethyl sulfoxide (DMSO)), across a temperature range 308–338 K pressure 12–30 MPa. exhibited ranging from 1.62 × 10–5 to 2.30 mole fractions pure CO2. In cosolvents, increased 5.76 12.79 ethanol 3.50 7.02 DMSO. Indeed, addition DMSO by approximately 3.55–5.56 times 2.15–3.05 times, respectively. Several density-based empirical models thermodynamic (Soave–Redlich–Kwong (SRK) Peng–Robinson (PR) equations state) used correlate data. Jafari Nejad's model CO2–Baclofen Jouyban's CO2–ethanol/DMSO–Baclofen systems displayed higher consistency. Also, PR showed better accuracy correlating while SRK outperformed CO2–ethanol/DMSO cosolvents. Moreover, machine learning exceptional accuracy, over 99% predictions closely matching experimental data, emphasizing its outstanding performance.

Language: Английский

Citations

1
Mechanistic Insights into Amorphous Solid Dispersions: Bridging Theory and Practice in Drug Delivery DOI

B Srividya,

Animesh Ghosh

Pharmaceutical Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

1
Comprehensive study of medications solubility in supercritical CO2 with and without co-solvent; Laboratory, theoretical, and intelligent approaches DOI
Chou‐Yi Hsu, Dheyaa J. Jasim, Pooja Bansal

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 411, P. 125765 - 125765

Published: Aug. 13, 2024

Language: Английский

Citations

3
Computational intelligence modeling and optimization of small molecule API solubility in supercritical solvent for production of drug nanoparticles DOI Creative Commons
Jiaxin Liang, H. Vicky Zhao, Shengxue Zhou

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 28, 2025

Language: Английский

Citations

0