Sonodynamic Cancer Therapy by Mn(I)‐tricarbonyl complexes via Ultrasound‐triggered CO release and ROS generation

Chemistry - A European Journal, Год журнала: 2024, Номер 31(3)

Опубликована: Ноя. 6, 2024

Abstract A novel ferrocene conjugated Mn(I)‐tricarbonyl complex viz [Mn(Fc‐tpy)(CO) 3 Br] ( Mn2 ) where, Fc‐tpy=4′‐ferrocenyl‐2,2′:6′,2′′‐terpyridine was synthesized and fully characterized along with its non‐ferrocene analog [Mn(Ph‐tpy)(CO) Ph‐tpy=4′‐phenyl‐2,2′:6′,2′′‐terpyridine Mn1 for ultrasound (US) activated anticancer applications. The X‐ray structure of confirmed distorted octahedral geometry. , the first time, showed US‐triggered release CO ROS generation 1 O 2 ⋅ OH) in an aqueous solution from any complexes, indicating potential synergetic gas therapy sonodynamic therapy. above‐mentioned in‐solution chemistry successfully translated into vitro cellular models. These complexes unprecedented toxicity against T‐cell lymphoma human breast cancer cells (IC 50 <1 μM) while were minimally toxic without US or normal spleen embryonic kidney cells. ca. 12 fold more active than that conjugation augmented sensitivity. apoptotic sonotoxicity due to US‐promoted mitochondrial depolarization via release. apoptosis triggered by caspase activation. This is report Mn(I)‐tricarbonyl‐based sonosensitizers SDT. Overall, this study, establishes effectiveness 3d metal carbonyls

Язык: Английский

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Sialic Acid-Targeted Ru(II)/Ir(III)/Re(I) Complexes for Ferroptosis Induction in Triple-Negative Breast Cancer

Langmuir, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Ferroptosis has been recognized as an iron-based nonapoptotic-regulated cell death process. In the quest of resisting unyielding vehemence triple-negative breast cancer (TNBC), herein we have showcased ferroptosis-inducing heteroleptic [LIrcRu], [LIrcIrh], and [LIrcRe] complexes, enabling them to selectively target "sialic acid", overexpressed cell-surface marker. The open-circuit potential (OCP) measurements in live cells revealed specific interaction between TNBC whereas control experiments with normal did not exhibit such interactions. GSH depletion, GPx4 inhibition, NADH/NADPH oxidation, lipid peroxidation, COX-2 activation, Nrf2 inactivation were meticulously investigated upon treatment these complexes establish a strong basis for ferroptosis. Among all complex [LIrcIrh] (IC50 = 25 ± 2.17 μM) well-documented potent ferroptosis inducer, which unveils sturdy sialic acid possessing highest binding constant (Kb 0.71 × 105 M–1, ΔG −279345.8026 kcal/mol) along serum albumin affinity (KHSA 0.67 106 M–1) significant DNA intercalation 0.56 Kapp 1.06 C50 is 76.56 μM), displaying decreased current intensity differential pulse voltammetry (DPV). Moreover, exhibited mitochondrial dysfunction membrane damage (diminished MMP, ΔΨm) through production copious reactive oxygen species (ROS) MDA-MB-231 considerable accumulation mitochondria (Pearson's coefficient 0.842). analysis field emission scanning electron microscopy (FE-SEM) image marked vivid induced by exhibiting ablaze evidence destruction

Язык: Английский

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Rhenium(I) and technetium(I) complexes with megazol derivatives: towards the development of a theranostic platform for Chagas disease

Dalton Transactions, Год журнала: 2024, Номер 53(48), С. 19153 - 19165

Опубликована: Янв. 1, 2024

This study suggests that megazol derivatives and their complexes with Re(CO) 3 + are potent trypanocidal agents having TcOYE as a possible biological target. The labelling of 99m Tc also indicates this system for theranostic applications.

Язык: Английский

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New palladium complexes based on myrtenal and benzylamine derivatives: Selectivity of cyclometalation, antitumor activity

Inorganica Chimica Acta, Год журнала: 2024, Номер unknown, С. 122457 - 122457

Опубликована: Ноя. 1, 2024

Язык: Английский

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