Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors DOI
Shuai Li, Xinyang Li, Tingjian Zhang

и другие.

Bioorganic Chemistry, Год журнала: 2020, Номер 96, С. 103575 - 103575

Опубликована: Янв. 10, 2020

Язык: Английский

Engaging an engineered PARP-2 catalytic domain mutant to solve the complex structures harboring approved drugs for structure analyses DOI
Xiaoyu Wang, Jie Zhou, Bailing Xu

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер unknown, С. 108471 - 108471

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Novel Brain-Tumor-Inhibiting Copper(II) Compound Based on a Human Serum Albumin (HSA)-Cell Penetrating Peptide Conjugate DOI
Zhenlei Zhang, Ping Yu, Yi Gou

и другие.

Journal of Medicinal Chemistry, Год журнала: 2019, Номер 62(23), С. 10630 - 10644

Опубликована: Ноя. 6, 2019

It is a great challenge to design drugs that penetrate the blood–brain barrier inhibit brain tumor growth by acting against multiple targets and also improve their delivery efficacy targeting ability cancer cells. To overcome above problems, we designed multitarget metal agent for treating tumors based on an human serum albumin (HSA)-cell penetrating peptide conjugate. Thus, rationally screened copper (Cu) 2-acetyl-3-ethylpyrazine thiosemicarbazones synthesize six compounds, investigated structure–activity relationships confirmed mechanisms glioma The HSA–6b complex structure indicated 6b binds IIA subdomain of HSA His242 replaces Br ligand in coordination with Cu2+. In vivo data suggested both HSA–6b–peptide conjugate few side effects. Furthermore, HSA–peptide improved vivo.

Язык: Английский

Процитировано

34
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs DOI
Shuai Li, Xinyang Li, Tingjian Zhang

и другие.

Bioorganic Chemistry, Год журнала: 2019, Номер 94, С. 103385 - 103385

Опубликована: Окт. 22, 2019

Язык: Английский

Процитировано

32
Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells DOI

Zhangxu He,

Jin-Ling Huo,

Yunpeng Gong

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2020, Номер 210, С. 112970 - 112970

Опубликована: Окт. 29, 2020

Язык: Английский

Процитировано

31
Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors DOI
Shuai Li, Xinyang Li, Tingjian Zhang

и другие.

Bioorganic Chemistry, Год журнала: 2020, Номер 96, С. 103575 - 103575

Опубликована: Янв. 10, 2020

Язык: Английский

Процитировано

28