Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors DOI
Shuai Li, Xinyang Li, Tingjian Zhang

et al.

Bioorganic Chemistry, Journal Year: 2020, Volume and Issue: 96, P. 103575 - 103575

Published: Jan. 10, 2020

Language: Английский

Engaging an engineered PARP-2 catalytic domain mutant to solve the complex structures harboring approved drugs for structure analyses DOI
Xiaoyu Wang, Jie Zhou, Bailing Xu

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108471 - 108471

Published: April 1, 2025

Language: Английский

Citations

0
Novel Brain-Tumor-Inhibiting Copper(II) Compound Based on a Human Serum Albumin (HSA)-Cell Penetrating Peptide Conjugate DOI
Zhenlei Zhang, Ping Yu, Yi Gou

et al.

Journal of Medicinal Chemistry, Journal Year: 2019, Volume and Issue: 62(23), P. 10630 - 10644

Published: Nov. 6, 2019

It is a great challenge to design drugs that penetrate the blood–brain barrier inhibit brain tumor growth by acting against multiple targets and also improve their delivery efficacy targeting ability cancer cells. To overcome above problems, we designed multitarget metal agent for treating tumors based on an human serum albumin (HSA)-cell penetrating peptide conjugate. Thus, rationally screened copper (Cu) 2-acetyl-3-ethylpyrazine thiosemicarbazones synthesize six compounds, investigated structure–activity relationships confirmed mechanisms glioma The HSA–6b complex structure indicated 6b binds IIA subdomain of HSA His242 replaces Br ligand in coordination with Cu2+. In vivo data suggested both HSA–6b–peptide conjugate few side effects. Furthermore, HSA–peptide improved vivo.

Language: Английский

Citations

34
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs DOI
Shuai Li, Xinyang Li, Tingjian Zhang

et al.

Bioorganic Chemistry, Journal Year: 2019, Volume and Issue: 94, P. 103385 - 103385

Published: Oct. 22, 2019

Language: Английский

Citations

32
Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells DOI

Zhangxu He,

Jin-Ling Huo,

Yunpeng Gong

et al.

European Journal of Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 210, P. 112970 - 112970

Published: Oct. 29, 2020

Language: Английский

Citations

31
Design, synthesis and biological evaluation of erythrina derivatives bearing a 1,2,3-triazole moiety as PARP-1 inhibitors DOI
Shuai Li, Xinyang Li, Tingjian Zhang

et al.

Bioorganic Chemistry, Journal Year: 2020, Volume and Issue: 96, P. 103575 - 103575

Published: Jan. 10, 2020

Language: Английский

Citations

28