Опубликована: Март 25, 2023
Chromenes and their derivatives are abundant in natural products biologically active molecules. Here we summarize the decades-long development of transition metal-catalyzed site-selective C–H functionalization chromene derivatives. This chapter describes 2 H -chromenes, -chromen-2-ones (coumarins), 4 -chromenes -chromen-4-ones (chromones).
Язык: Английский
Inorganics, Год журнала: 2022, Номер 10(2), С. 23 - 23
Опубликована: Фев. 15, 2022
For several decades, coumarins have attracted considerable attention due to the fact of their application in diverse fields such as medical science and biomedical research well industrial branches. Recently, many compounds containing coumarin moiety been intensively studied, mainly biological activities antitumor, antioxidative, anti-HIV, vasorelaxant, antimicrobial, anticancer. They are also widely used fluorescent dyes probes because great structural flexibility large quantum yields. this reason, numerous attempts made develop new more practical methods for synthesis these compounds. This review aims at providing a comprehensive overview by direct C–H bond activation order demonstrate current state-of-the-art limitations.
Язык: Английский
Процитировано
24
Chinese Chemical Letters, Год журнала: 2023, Номер 34(9), С. 108396 - 108396
Опубликована: Март 30, 2023
Язык: Английский
Процитировано
15
Organic Letters, Год журнала: 2021, Номер 23(15), С. 5952 - 5957
Опубликована: Июль 29, 2021
The Rh(III)-catalyzed dual directing group assisted C–H activation/annulation of 3-arylisoxazolones with propargyl alcohols has been developed, which expands the application scope isoxazolones in organic synthesis. This protocol also worked well 3-aryl-1,4,2-dioxazol-5-ones to produce synthetically and biologically important 4-arylisoquinolones.
Язык: Английский
Процитировано
24
Synthetic Communications, Год журнала: 2022, Номер 52(21), С. 1999 - 2018
Опубликована: Сен. 7, 2022
This review presents a vast body of literature on various synthetic methodology, biological, and fluorescence activities pyrrolo[3,4‑c]coumarins as published during the last 20–30 years. Synthesized have been reported in by construction either pyrrole, indole, or both rings via different methodology including metal-catalyzed reactions, green reaction protocols starting from readily accessible substrates.
Язык: Английский
Процитировано
17
Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(48), С. 9522 - 9588
Опубликована: Янв. 1, 2022
Recent advances in the synthesis of conjugated dienes via transition metal-catalyzed double C vinyl –H bond activation.
Язык: Английский
Процитировано
15
Organic Chemistry Frontiers, Год журнала: 2021, Номер 8(22), С. 6350 - 6355
Опубликована: Янв. 1, 2021
The first Ru( ii )-catalyzed cascade C–H activation/annulation reactions of N -aryl-pyrazolidinones with sulfoxonium ylides are reported.
Язык: Английский
Процитировано
18
Chemistry - A European Journal, Год журнала: 2023, Номер 29(25)
Опубликована: Янв. 10, 2023
Mn(I) C-H functionalization of coumarins provides a versatile and practical method for the rapid assembly fused polycyclic pyridinium-containing in regioselective manner. The synthetic strategy enables application bench-stable organomanganese reagents both photochemical- thermal-promoted reactions. cyclomanganated intermediates, global reaction system, provide an ideal testing ground structural characterization active carbonyl-containing species, including transient species observable by ultra-fast time-resolved spectroscopic methods. thermodynamic reductive elimination product, solely encountered from between alkynes air-stable organometallic coumarins, has enabled critical seven-membered intermediate, detected infrared spectroscopy, enabling elucidation temporal profile key steps pathway. Quantitative data are provided. Manganated products readily decomplexed AgBF
Язык: Английский
Процитировано
7
Organic Letters, Год журнала: 2021, Номер 23(16), С. 6272 - 6277
Опубликована: Июль 30, 2021
An efficient synthesis of indolo[2,1-a]benzazepinones through rhodium-catalyzed cascade reactions 2-arylindoles with allyl alcohols has been developed. This work expands the scope products that are available C–H activation/intramolecular annulation in organic synthesis.
Язык: Английский
Процитировано
14
Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(21), С. 3713 - 3717
Опубликована: Сен. 16, 2023
Abstract We herein disclose a simple and general method for the synthesis of chromendiones through Rh(III)‐catalyzed C−H functionalization/annulation reactions nitrones with cyclic 2‐diazo‐1,3‐diones by using nitrone group as traceless directing group. This exhibits high efficiency broad functional compatibility. The derivatization these has been also demonstrated to further strengthen synthetic utility transformation.
Язык: Английский
Процитировано
4
European Journal of Organic Chemistry, Год журнала: 2021, Номер 2021(17), С. 2411 - 2420
Опубликована: Апрель 6, 2021
Abstract Herein, we describe two types of C5 functionalization reactions chromones with allyl alcohols. Diverse 5‐substituted can be produced by modulating the catalysts in these reactions: Rh(III) results formation 5‐alkylated chromones, and Ru(II) furnishes 5‐alkenylated products. We also achieve further functionalizations which demonstrates superiority this method. Notable features new methods include readily available precursors, tunable reactivity, exclusive C5‐selectivity, easy derivatization
Язык: Английский
Процитировано
9