A Review on Molecular Iodine Catalyzed/Mediated Multicomponent Reactions

Asian Journal of Organic Chemistry, Год журнала: 2022, Номер 12(1)

Опубликована: Ноя. 26, 2022

Abstract In multicomponent reactions, three or more reactants combine in one pot to form a product without the isolation of intermediate and most contribute newly formed reducing number steps involved waste generated. Molecular iodine is mild, efficient, relatively nontoxic, inexpensive, commercially available, catalyzes various organic reactions due its Lewis acidic behaviour. The development catalyzed by molecular indeed good green alternative for synthetic chemistry. aim this article review all important reported since 2013 order envisage some new efficient protocols synthesis structurally complex molecules.

Язык: Английский

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Oxidative dual C–H sulfenylation: A strategy for the synthesis of bis(imidazo[1,2-a]pyridin-3-yl)sulfanes under metal-free conditions using sulfur powder

Chinese Chemical Letters, Год журнала: 2020, Номер 32(5), С. 1705 - 1708

Опубликована: Дек. 28, 2020

Язык: Английский

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Supramolecular aggregation patterns featuring Se⋯N secondary-bonding interactions in mono-nuclear selenium compounds: A comparison with their congeners

Coordination Chemistry Reviews, Год журнала: 2021, Номер 443, С. 214031 - 214031

Опубликована: Май 26, 2021

Язык: Английский

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Copper-Catalyzed C-3 Functionalization of Imidazo[1,2-a]pyridines with 3-Indoleacetic Acids

The Journal of Organic Chemistry, Год журнала: 2021, Номер 86(17), С. 12394 - 12402

Опубликована: Авг. 13, 2021

A copper-catalyzed C-3 functionalization of imidazo[1,2-a]pyridines with 3-indoleacetic acids through an aerobic oxidative decarboxylative process has been developed. The protocol provided a series 3-(1H-indol-3-ylmethyl)-imidazo[1,2-a]pyridines in moderate to good yields under simple reaction conditions. Importantly, some products exhibited potent antiproliferative activity cancer cell lines.

Язык: Английский

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Visible-Light-Promoted Selenocyanation of Cyclobutanone Oxime Esters Using Potassium Selenocyanate

The Journal of Organic Chemistry, Год журнала: 2021, Номер 86(17), С. 11399 - 11406

Опубликована: Авг. 9, 2021

We report the visible-light-promoted selenocyanation of cyclobutanone oxime esters using potassium selenocyanate in presence a fac-Ir(ppy)3 catalyst for first time. Because mild conditions employed and use readily accessible selenocyanate, this method is an effective green strategy synthesis cyano selenocyano bifunctional substituted alkanes.

Язык: Английский

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Transition Metal-free Direct C(sp2)-H Thiocyanation of 2-Iminothiazolines at Room Temperature

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134756 - 134756

Опубликована: Май 1, 2025

Язык: Английский

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Ruthenium-Catalyzed C(sp²)–H Bond Bisallylation with Imidazopyridines as Directing Groups

The Journal of Organic Chemistry, Год журнала: 2020, Номер 85(23), С. 15167 - 15182

Опубликована: Ноя. 3, 2020

A Ru(II)-catalyzed bisallylation of imidazopyridines with vinylcyclopropanes or vinyl cyclic carbonate has been successfully realized. Notably, pharmacophore imidazopyridine was utilized as an intrinsic directing group, which gave access to value-added bisallylated products in high yields via double tandem C-H and C-C/C-O activation. The current methodology featured broad substrate scope, good functional group compatibility, operational simplicity.

Язык: Английский

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Iodine pentoxide-mediated oxidative selenation and seleno/thiocyanation of electron-rich arenes

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(27), С. 5463 - 5469

Опубликована: Янв. 1, 2022

A simple and efficient method for the regioselective selenation of electron-rich arenes by employing non-metal inorganic iodine pentoxide (I2O5) as a reaction promoter under ambient conditions has been developed. The present protocol showed broad functional group tolerance easy-to-operate time-economical features. Additionally, this also allows access to 3-seleno 3-thiocyanoindoles use readily available selenocyanate thiocyanate salts. mechanistic study indicated that transformation operated through selenenyl iodide-induced electrophilic substitution processes.

Язык: Английский

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Electrochemical-induced regioselective C-3 thiocyanation of imidazoheterocycles with hydrogen evolution

Tetrahedron Letters, Год журнала: 2021, Номер 65, С. 152755 - 152755

Опубликована: Янв. 7, 2021

Язык: Английский

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Regioselective N–F and α C(sp³)–H Arylation of Aliphatic N-Fluorosulfonamides with Imidazopyridines

Organic Letters, Год журнала: 2021, Номер 23(17), С. 6807 - 6812

Опубликована: Авг. 18, 2021

A regioselective arylation of aliphatic N-fluorosulfonamides with imidazopyridines enabled by breaking N–F and α C(sp3)–H bond to form C–N C–C bonds was described. With CuCl as the catalyst, a radical mechanism proposed produce N-arylated sulfonamides via N intermediate. Importantly, under acidic conditions, an in situ generated imine possible intermediate, which trapped arylated sulfonamides. The current protocol featured broad substrate scope, tunable reaction operational convenience, good regioselectivity.

Язык: Английский

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