We
report
on
the
preparation
of
synthetically
versatile
N-carboxyanhydrides
(NCAs)
directly
from
amino
acids
and
CO2
using
n-propylphosphonic
anhydride.
Most
NCAs
were
isolated
with
>95%
purity
after
simple
workup,
avoiding
need
for
tedious
purification
procedures
typically
required
conventional
methods.
Because
reagents
conditions
employed
are
mild,
tandem
reactions
moisture-sensitive
carried
out
to
transform
them
into
medicinally
active
alkaloids
tryptanthrin
phaitanthrin
A
in
one
pot.
qualitative
analysis
revealed
that
our
NCA
synthesis
approach
is
more
green
than
methods,
which
all
or
indirectly
use
highly
poisonous
gas
phosgene.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Июнь 14, 2023
Photocatalytic
carboxylation
of
alkenes
with
CO2
is
a
promising
and
sustainable
strategy
to
synthesize
high
value-added
carboxylic
acids.
However,
it
challenging
rarely
investigated
for
unactivated
due
their
low
reactivities.
Herein,
we
report
visible-light
photoredox-catalyzed
arylcarboxylation
CO2,
delivering
variety
tetrahydronaphthalen-1-ylacetic
acids,
indan-1-ylacetic
indolin-3-ylacetic
chroman-4-ylacetic
acids
thiochroman-4-ylacetic
in
moderate-to-good
yields.
This
reaction
features
chemo-
regio-selectivities,
mild
conditions
(1
atm,
room
temperature),
broad
substrate
scope,
good
functional
group
compatibility,
easy
scalability
facile
derivatization
products.
Mechanistic
studies
indicate
that
situ
generation
carbon
dioxide
radical
anion
following
addition
might
be
involved
the
process.
RSC Medicinal Chemistry,
Год журнала:
2024,
Номер
15(4), С. 1127 - 1147
Опубликована: Янв. 1, 2024
Tryptanthrin
with
a
broad
spectrum
of
biological
activities
can
be
not
only
decorated
by
various
functional
groups,
but
also
coordinated
bio-metal
ions,
generating
varied
tryptanthrin
derivatives
as
potential
anticancer
agents
low
toxicity.
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
Symmetrical
bis(hydrazone)-based
ligands,
H4dar(bhz)2
(I),
H4dar(fah)2
(II),
H4dar(nah)2
(III),
and
H4dar(inh)2
(IV)
obtained
from
4,6-diacetylresorcinol
(H2dar)
different
hydrazides
[benzoylhydrazide
(Hbhz),
isonicotinoylhydrazide
(Hinh),
nicotinoylhydrazide
(Hnah),
2-furoylhydrazide
(Hfah)],
were
used
to
prepare
potassium
salts
of
binuclear
cis-[VVO2]+
complexes,
{K(H2O)2}2[(VVO2)2dar(bhz)2]
(1),
{K(H2O)2}2[(VVO2)2dar(fah)2]
(2),
{K(H2O)2}2[(VVO2)2dar(nah)2]
(3),
{K(H2O)2}2[(VVO2)2dar(inh)2]
(4),
[VIVO]2+
[{VIVO(MeOH)}2dar(bhz)2]
(5),
[{VIVO(MeOH)}2dar(fah)2]
(6),
[{VIVO(MeOH)}2dar(nah)2]
(7),
[{VIVO(MeOH)}2dar(inh)2]
(8).
In
the
presence
warm
MeOH/DMSO
(4:1),
3
changed
{K(H2O)2}[(VVO2)2Hdar(nah)2]·DMSO
(3a·DMSO).
Single
crystal
XRD
studies
1
3a
confirm
a
structure
along
with
distorted
square
pyramidal
geometry
each
vanadium
center
where
bis{ONO(2-)}
ligands
coordinate
through
phenolate-O,
azomethine-N,
enolate-O
atoms
unit.
While
growing
crystals
6
in
EtOH,
part
it
oxidizes
gives
[{VVO(OEt)}2dar(fah)2]
(9)
powdery
6.
Complex
9
has
octahedral
structure.
These
complexes
as
catalysts
for
synthesis
biologically
important
2-phenylquinazolin-4-(3H)-ones
having
aryl
aldehydes,
they
all
show
excellent
catalytic
performance
(up
97%
yield)
less
reaction
time
low
temperature,
70%
aqueous
TBHP/30%
H2O2
greener
oxidant.
Generally,
these
perform
better
than
their
mononuclear
analogues.
Spectroscopy,
DFT
studies,
isolated
intermediates
have
helped
proposing
suitable
mechanism
reaction.
Russian Chemical Reviews,
Год журнала:
2025,
Номер
94(4), С. RCR5167 - RCR5167
Опубликована: Апрель 1, 2025
The
development
of
convenient
methods
for
the
synthesis
heterocyclic
compounds
that
are
highly
important
search
pharmacological
substances
and
in
other
spheres
human
activity
is
among
most
relevant
fields
organic
chemistry.
Two
functional
groups
arenes
located
adjacent
positions
benzene
ring
can
provide
a
fused
ring.
If
at
least
one
two
<i>ortho</i>-functional
contains
nitrogen
atom,
heterocycle
formed
upon
cyclization.
nitro
group
often
chosen
as
nitrogen-containing
<i>ortho</i>-substituted
to
form
systems,
because
ready
availability
<i>ortho</i>-functionalized
nitroarenes,
ability
undergo
various
reactions
selectivity
reactions.
This
review
integrates
analyzes
first
time
published
data
on
involvement
nitroarenes
design
structures.
Using
numerous
examples
reported
literature
last
decade,
mutually
beneficial
effect
groups,
which
group,
formation
heterocycles
demonstrated.
Examples
both
intramolecular
cyclizations
involving
additional
reagents
considered.
gives
holistic
view
potential
functionalized
<i>ortho</i>-nitroarenes
systems.
<br>
bibliography
includes
132
references.
We
report
a
photocatalytic
strategy
for
direct
amide
synthesis
from
readily
available
nitroarenes
and
benzoylformic
acids
using
flavin
as
an
efficient
photocatalyst.
This
one-pot
transformation
proceeds
through
tandem
reduction-decarboxylation-amidation
sequence
under
mild
blue
light
irradiation.
Preliminary
mechanistic
studies
indicated
that
nitrosoarene
N-hydroxyamides
could
be
the
key
intermediates.
The
method
demonstrates
broad
substrate
scope,
excellent
functional
group
tolerance,
remarkable
operational
simplicity,
it
can
conducted
ambient
atmosphere.
Notably,
this
protocol
represents
significant
advancement
in
step
economy
by
directly
employing
diverse
nitrogen
sources,
avoiding
need
pre-reduced
amine
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(15), С. 10701 - 10710
Опубликована: Июль 20, 2023
A
short,
proficient,
and
regioselective
synthesis
of
biheterocyclic
5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones
has
been
revealed
via
an
Fe(0)-powder-mediated,
one-pot
reductive
cyclization
protocol.
Mechanistic
investigation
proved
that
water
acts
as
a
source
hydrogen
for
the
reduction
nitro
group
reaction
rate
was
accelerated
by
aldehyde.
The
designed
transformation
works
under
aerobic
conditions,
providing
series
bio-inspired
molecular
scaffolds.
In
addition,
photophysical
study
showed
blue
fluorescence
emission
with
good
quantum
yield.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(42), С. 49246 - 49258
Опубликована: Окт. 16, 2023
The
supramolecular
assemblies
of
the
donor–acceptor
(D–A)
system
Im-Tpy,
having
phenanthro[9,10-d]imidazole
as
donor
and
terpyridyl
group
acceptor
unit,
have
been
developed,
which
serve
host
to
stabilize
Co(II)
in
its
nanoform.
as-prepared
nanoensemble
Im-Tpy@Co
DMSO:water
(7:3)
shows
high
thermal
stability
photostability.
Even
case
solvent
mismatch,
i.e.,
on
dilution
with
cosolvent
THF/DMSO,
insignificant
changes
were
observed
size/morphology
nanoensemble.
low
catalytic
loading
(0.1
mol
%
Co)
catalyzes
oxidation
a
wide
variety
alcohols
aromatic
aldehydes/ketones
using
visible
light
radiations
source
energy
without
need
any
additive
at
room
temperature.
In
comparison
already
reported
systems,
exhibits
turnover
numbers
(TONs)
frequencies
(TOFs).
practical
application
has
also
demonstrated
gram-scale
synthesis
4-chlorobenzaldehyde.
recyclability
up
four
cycles
leaching
morphological
changes.
present
study
demonstrates
activity
"one-pot"
quinazolin-4(3H)-ones
from
2-aminobenzamide
primary
better
efficiency
other
transition-metal-based
systems.
Journal of Saudi Chemical Society,
Год журнала:
2023,
Номер
27(2), С. 101621 - 101621
Опубликована: Фев. 25, 2023
An
environmentally
benign
highly
atom-economic
protocol
for
the
construction
of
CC
bond
has
been
developed
under
catalyst-
and
solvent-free
conditions.
This
involves
efficient
coupling
2-methyl
quinazolinones
with
3-(trifluoroacetyl)coumarins
access
quinazolinone
derivatives
in
excellent
yields
(up
to
90
%).
The
crystal
structure
compound
3di
was
investigated
by
X-ray
diffraction
analysis.
biological
activities,
such
as
vitro
antifungal
activity
against
Fusarium
graminearum,
moniliforme,
oxysporum,
Phytophthora
parasitica
var
nicotianae,
Rhizoctonia
solani
Kuhn,
were
investigated.
bioassay
results
indicated
that
most
target
products
exhibited
promising
fungicidal
3
cl
95
%
R.
solani,
an
EC50
value
10.6
μg/mL.
