ACS Omega,
Год журнала:
2023,
Номер
8(28), С. 25349 - 25357
Опубликована: Июль 5, 2023
Herein,
we
report
an
efficient
method
for
synthesis
of
novel
selenocyanates
amino
pyrazole,
uracil,
and
isoxazole
derivatives
using
in
situ
triselenium
dicyanide
from
the
combination
malononitrile
selenium
dioxide
DMSO
medium.
Using
same
but
changing
stoichiometry
reagents
sequence
addition
temperature,
symmetrical
selenoethers
pyrazoles
uracils
were
prepared
good
yields.
Furthermore,
utilized
corresponding
alkynyl
selenides
presence
CuI
Cs2CO3.
The
salient
features
this
methodology
are
inexpensive
starting
materials,
short
reaction
time,
to
very
This
is
also
applicable
gram-scale
uracils.
Organic Letters,
Год журнала:
2023,
Номер
25(26), С. 4918 - 4922
Опубликована: Июнь 28, 2023
A
general
and
facile
approach
for
the
direct
oxidative
α-acyloxylation
of
ketones
using
molecular
oxygen
as
oxidant
is
developed.
This
method
avoids
use
excessive
peroxides
expensive
metal
catalysts,
affording
a
variety
α-acyloxylated
in
satisfactory
yields.
Experimental
studies
indicate
that
reaction
proceeds
via
radical
pathway.
Additionally,
α-hydroxy
could
be
obtained
by
changing
solvent.
RSC Advances,
Год журнала:
2022,
Номер
12(23), С. 14502 - 14508
Опубликована: Янв. 1, 2022
Herein,
we
describe
a
simple
and
general
multi-component
synthesis
of
5-arylselanyluracils
by
the
regioselective
C-H
selenation
uracils.
Reactions
uracils
with
arylboronic
acid
Se
powder
in
presence
AgNO3
(10
mol%)
at
120
°C
under
aerobic
conditions
afforded
various
5-arylselanyluracils.
The
source
introduced
selanyl
group
was
prepared
from
commercially
available
reaction
system,
thereby
ensuring
efficient
protocol.
This
represents
first
example
5-arylselanyluracil
system.
Abstract
Herein
we
report
acid
mediated
two
and
three‐component
domino
reactions
of
cyclic
enamines
such
as
2‐amino‐1,4‐naphthoquinone,
6‐amino‐1,3‐dimethyluracil
with
arylglyoxals
for
the
synthesis
diverse
fused
pyrroles.
The
two‐component
reaction
arylglyoxal
2‐amino‐1,4‐naphthoquinone
in
acetic
medium
provided
substituted
naphthoquinone‐fused
pyrroles
tethered
hydroxyl
aryl
substituents.
On
other
hand,
under
similar
conditions,
phenylglyoxal
an
unusual
bipyrrolopyrimidine
a
quaternary
carbon
center
following
involving
formation
five
new
sigma
bonds
one‐pot.
Interestingly,
ethanol
presence
10‐mol%
PTSA
product
having
pyrimidine
pyrrole
linked
6‐aminouracil
moiety.
We
have
also
developed
arylglyoxals,
4‐hydroxy‐1‐methylquinolin‐2(1H)‐one
hydroxyquinoline
derivatives.
ACS Omega,
Год журнала:
2023,
Номер
8(28), С. 25349 - 25357
Опубликована: Июль 5, 2023
Herein,
we
report
an
efficient
method
for
synthesis
of
novel
selenocyanates
amino
pyrazole,
uracil,
and
isoxazole
derivatives
using
in
situ
triselenium
dicyanide
from
the
combination
malononitrile
selenium
dioxide
DMSO
medium.
Using
same
but
changing
stoichiometry
reagents
sequence
addition
temperature,
symmetrical
selenoethers
pyrazoles
uracils
were
prepared
good
yields.
Furthermore,
utilized
corresponding
alkynyl
selenides
presence
CuI
Cs2CO3.
The
salient
features
this
methodology
are
inexpensive
starting
materials,
short
reaction
time,
to
very
This
is
also
applicable
gram-scale
uracils.
