The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(19), С. 13634 - 13644
Опубликована: Сен. 8, 2023
Herein,
we
reported
an
efficient
and
facile
visible-light-induced
3-alkyl
chromone
synthesis
from
easily
accessible
o-hydroxyaryl
enaminones
α-diazo
esters.
In
this
protocol,
excellent
yields
were
obtained
with
a
broad
substrate
scope
at
room
temperature,
tolerating
various
functional
groups.
Of
note
is
that
eco-friendly
methodology
features
catalyst-
additive-free,
mild
reaction
conditions,
simple
operation
procedure,
easy
scale-up,
which
affords
convenient
pathway
for
the
preparation
of
chromones.
Experimental
results
density
theory
(DFT)
computation
analyses
confirm
participation
carbene
species
active
cyclopropane
intermediate.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(9), С. 5586 - 5596
Опубликована: Апрель 6, 2023
Herein,
we
present
a
practical
strategy
for
the
direct
construction
of
structurally
diverse
trifluoromethyl
carbinol-containing
compounds,
especially
CF3-substituted
tertiary
alcohol
with
chromone
derivatives
from
easily
available
o-hydroxyaryl
enaminones
and
trifluoroacetaldehyde/ketone
under
metal-free
conditions.
This
reaction
features
broad
substrate
scope
good
yields
is
scaled
up.
Notably,
one-pot
in
two-steps
obtained
products
amidines
also
developed
to
provide
series
multi-substituted
pyrimidine
bearing
two
unique
hydroxyls
one
containing
functional
units.
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(8), С. 1591 - 1628
Опубликована: Янв. 1, 2023
Photoredox
catalysis
has
demonstrated
rapid
evolution
in
the
field
of
synthetic
organic
chemistry.
On
other
hand,
splendour
cascade
reactions
providing
complex
molecular
architectures
renders
them
a
cutting-edge
research
area.
Therefore,
merging
photocatalysis
with
synthesis
brings
out
paradigm
immense
potential.
The
development
photocascade
for
target
molecule
particular
skeleton
and
stereochemical
framework
presents
certain
challenges
but
provides
robust
environmentally
benign
alternative.
This
comprehensive
review
assembles
all
accomplishments
highlights
visible-light-induced
literature
coverage
up
to
October
2022.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(10), С. 2363 - 2369
Опубликована: Март 16, 2024
Abstract
A
synthetic
protocol
was
developed
to
synthesize
highly
functionalized
3‐furylmethyl
chromones
from
enynones
and
o
‐hydroxyphenyl
enaminones
via
silver‐catalyzed
cascade
bis‐heteroannulation
reaction.
This
strategy
features
broad
substrate
scope
good
functional
group
tolerance.
Furthermore,
the
chromone
skeleton
shows
potential
application
value
through
further
gram‐scale
synthesis
derivatization.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(14), С. 3906 - 3912
Опубликована: Янв. 1, 2024
A
chemodivergent
and
skeleton-controllable
annulation
reactions
of
readily
available
o
-HPEs
aryldiazonium
salts
was
described
for
the
synthesis
highly
functionalized
pyridazine-fused
chromones
with
high
antiviral
activity
higher
safety.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(12), С. 8248 - 8255
Опубликована: Май 26, 2022
Ultrasound
has
been
successfully
employed
to
promote
the
thiocyanation
of
C═C
bond
in
enaminones
for
synthesis
α-thiocyanoketones
and
2-aminothiazoles.
The
reactions
with
ammonium
thiocyanate
provide
ultrasound
irradiation
at
room
temperature.
More
interestingly,
simply
further
heating
vessel
after
ultrasonic
leads
selective
2-aminothiazoles
an
unconventional
4-aryl
substructure.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(6), С. 4017 - 4023
Опубликована: Март 2, 2023
A
facile
cascade
reaction
for
the
site
selective
synthesis
of
2-cyanochromones
is
described.
By
using
simple
o-hydroxyphenyl
enaminones
and
potassium
ferrocyanide
trihydrate
(K4[Fe(CN)6]3·3H2O)
as
starting
materials
I2/AlCl3
promoters,
products
are
furnished
via
tandem
chromone
ring
formation
C–H
cyanation.
The
in
situ
3-iodochromone
a
formal
1,2-hydrogen
atom
transfer
(HAT)
process
account
unconventional
selectivity.
In
addition,
2-cyanoquinolin-4-one
has
been
realized
by
employing
corresponding
2-aminophenyl
enaminone
substrate.
Chemical Communications,
Год журнала:
2023,
Номер
59(45), С. 6885 - 6888
Опубликована: Янв. 1, 2023
The
annulation
reactions
of
enaminones
with
quinonediimides/quinoneimides
for
the
selective
synthesis
indoles
and
2-aminobenzofurans
have
been
realized.
With
Zn(II)
catalysis,
quinonediimides
reacted
to
give
via
HNMe2-elimination-based
aromatization.
Fe(III)
quinoneimides
provided
a
key
dehydrogenative
