Abstract
The
development
of
innovative
synthetic
strategies
for
constructing
complex
molecular
structures
is
the
heart
organic
chemistry.
This
significance
novel
reactions
or
reaction
sequences
would
further
enhance
if
they
permitted
synthesis
new
classes
structural
motifs,
which
have
not
been
previously
created.
research
on
heterocyclic
compounds
one
most
active
topics
in
chemistry
due
to
widespread
application
N‐heterocycles
life
and
material
science.
a
catalytic
process
that
employs
first‐row
transition
metals
produce
range
heterocycles
from
renewable
raw
materials
considered
highly
sustainable
approach.
be
more
advantageous
done
an
eco‐friendly
atom‐efficient
manner.
Herein
we
introduce,
various
quinoline
based
azafluorenes
via
sequential
dehydrogenative
multicomponent
(MCR)
followed
by
C(sp
3
)−H
hydroxylation
annulation.
Our
newly
developed,
Mn‐complexes
ability
direct
order
achieve
high
amount
desired
functionalized
while
minimizing
possibility
multiple
side
reactions.
We
also
performed
series
control
experiments,
hydride
trapping
kinetics,
intermediate
DFT
studies
comprehend
detailed
route
catalyst‘s
function
MCR
sequence.
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 26, 2024
Abstract
Herein
we
first
report
the
unprecedented
synthesis
of
tetrazene‐based
cobalt
complexes
using
unusual
coupling
amines
via
dehydrogenation.
These
were
employed
for
dehydrogenative
reactions
to
synthesize
N‐heterocycles
(quinoline,
and
quinazolinone).
Based
on
control
experiments
IR
identification
intermediates,
proposed
a
plausible
reaction
mechanism.
Synthesis
protocols
utilized
preparative
scale
biologically
active
molecule
(±)‐galipinine
synthesis.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(23), С. 4704 - 4719
Опубликована: Янв. 1, 2024
This
protocol
is
solvent
free,
requires
a
lower
amount
of
phosphine-free
highly
stable
catalyst,
produces
an
excellent
yield
with
green
by-product
only.
Besides,
it's
applicability
in
broad
substrate
scope
and
scalable
as
well.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
In
this
report,
a
new
imidazole-
and
amide-functionalized
pincer-like
Cu(II)
complex
(1)
was
synthesized
characterized.
By
employing
1
9-azabicyclo[3.3.1]nonane
NH-Oxyl
(ABNOH),
catalytic
protocol
for
alcohol
oxidation
the
subsequent
oxidation-triggered
synthesis
of
quinolines
pyrazines
were
explored.
Alcohols
such
as
2-aminoaryl
alcohols
also
oxidized
efficiently.
As
carbonyls
from
2-arylaminobenzyl
secondary
are
synthons
quinolines,
we
explored
their
directly
alcohols.
The
quite
efficient
completed
reaction
in
only
∼5–10
h.
Combinations
(a)
primary
with
or
ketones
(b)
found
to
be
very
effective
quinolines.
successful
various
1,2-diols
1,2-diaminobenzenes
10
Mechanistic
investigations
showed
that
generated
acted
an
active
catalyst:
it
activated
O2
subsequently
cooperation
N-Oxyl
(ABNO•)
α-CH
hydrogen
coordinated
alkoxide.
Then,
Cu(II)/Cu(I)
reduction
led
formation
carbonyl
compounds,
which
via
successive
C–C/C–N
coupling
reactions
resulted
heterocycles
presence
KOtBu
1.
New Journal of Chemistry,
Год журнала:
2023,
Номер
48(3), С. 1327 - 1335
Опубликована: Дек. 8, 2023
The
synthesis
of
single
phase
δ
-MnO
2
NPs
was
carried
out
utilising
an
environmentally
benign
biogenic
method.
prepared
catalyst
utilized
for
benzimidazoles
and
dihydroperimidines
the
dye
removal
study
with
exceptional
catalytic
activity.
Abstract
The
development
of
innovative
synthetic
strategies
for
constructing
complex
molecular
structures
is
the
heart
organic
chemistry.
This
significance
novel
reactions
or
reaction
sequences
would
further
enhance
if
they
permitted
synthesis
new
classes
structural
motifs,
which
have
not
been
previously
created.
research
on
heterocyclic
compounds
one
most
active
topics
in
chemistry
due
to
widespread
application
N‐heterocycles
life
and
material
science.
a
catalytic
process
that
employs
first‐row
transition
metals
produce
range
heterocycles
from
renewable
raw
materials
considered
highly
sustainable
approach.
be
more
advantageous
done
an
eco‐friendly
atom‐efficient
manner.
Herein
we
introduce,
various
quinoline
based
azafluorenes
via
sequential
dehydrogenative
multicomponent
(MCR)
followed
by
C(sp
3
)−H
hydroxylation
annulation.
Our
newly
developed,
Mn‐complexes
ability
direct
order
achieve
high
amount
desired
functionalized
while
minimizing
possibility
multiple
side
reactions.
We
also
performed
series
control
experiments,
hydride
trapping
kinetics,
intermediate
DFT
studies
comprehend
detailed
route
catalyst‘s
function
MCR
sequence.
