Electrochemical Late-Stage Functionalization
Chemical Reviews,
Год журнала:
2023,
Номер
123(19), С. 11269 - 11335
Опубликована: Сен. 26, 2023
Late-stage
functionalization
(LSF)
constitutes
a
powerful
strategy
for
the
assembly
or
diversification
of
novel
molecular
entities
with
improved
physicochemical
biological
activities.
LSF
can
thus
greatly
accelerate
development
medicinally
relevant
compounds,
crop
protecting
agents,
and
functional
materials.
Electrochemical
synthesis
has
emerged
as
an
environmentally
friendly
platform
transformation
organic
compounds.
Over
past
decade,
electrochemical
late-stage
(eLSF)
gained
major
momentum,
which
is
summarized
herein
up
to
February
2023.
Язык: Английский
Transition Metal‐Catalyzed C−H Functionalization Through Electrocatalysis
ChemSusChem,
Год журнала:
2023,
Номер
16(12)
Опубликована: Март 7, 2023
Electrochemically
promoted
transition
metal-catalyzed
C-H
functionalization
has
emerged
as
a
promising
area
of
research
over
the
last
few
decades.
However,
development
in
this
field
is
still
at
an
early
stage
compared
to
traditional
reactions
using
chemical-based
oxidizing
agents.
Recent
reports
have
shown
increased
attention
on
electrochemically
functionalization.
From
standpoint
sustainability,
environmental
friendliness,
and
cost
effectiveness,
oxidation
metal
catalyst
offers
mild,
efficient,
atom-economical
alternative
chemical
oxidants.
This
Review
discusses
advances
metal-electrocatalyzed
past
decade
describes
how
unique
features
electricity
enable
economic
sustainable
way.
Язык: Английский
Demystifying the recent photochemical and electrochemical tricks on installing the magic methyl group: A comprehensive overview
Feiyang Liao,
Zenghui Wei,
Yunhao Guan
и другие.
Green Chemistry,
Год журнала:
2024,
Номер
26(14), С. 8161 - 8203
Опубликована: Янв. 1, 2024
The
strategic
installation
of
the
“magic
methyl”
group
has
become
highly
desirable
for
drug
discovery.
This
review
summarized
recent
photochemical
and
electrochemical
strategies
in
installing
methyl
group.
Язык: Английский
Electrochemically driven oxidative C–H/N–H cross-coupling reactions of cyclic sulfamidate imines with primary anilines and secondary amines
Green Chemistry,
Год журнала:
2022,
Номер
24(21), С. 8377 - 8385
Опубликована: Янв. 1, 2022
An
efficient
and
eco-friendly
electrochemical
synthesis
of
various
cyclic
N
-sulfonylamidines
from
sulfamidate
imines
amines
via
oxidative
C–H/N–H
cross-coupling
under
mild
reaction
conditions
has
been
developed.
Язык: Английский
Catalyst-free benzylic C(sp3)–H cross-coupling with organotrifluoroborates enabled by electrochemistry
Green Chemistry,
Год журнала:
2022,
Номер
24(20), С. 7883 - 7888
Опубликована: Янв. 1, 2022
An
electrochemical
benzylic
C(sp
3
)–H
cross-coupling
with
organotrifluoroborates
without
any
catalyst
or
external
electrolyte
has
been
developed.
Язык: Английский
Electrooxidative iridium-catalyzed sp2 C−H activation-annulation leading to cationic π-extended heteroaromatics
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(17), С. 4849 - 4856
Опубликована: Янв. 1, 2024
An
electrochemically
driven,
Cp*Ir(
iii
)-catalyzed
method
for
alkenyl
and
aromatic
C(sp
2
)–H
activation
coupling
with
alkynes
the
synthesis
of
biologically
useful
quaternary
ammonium
salts
under
mild
conditions
is
demonstrated.
Язык: Английский
Hydrogen evolution-enabled rhodaelectro-catalyzed [4+2] annulations of purines and 7-deazapurines with alkynes
Chemical Communications,
Год журнала:
2022,
Номер
58(68), С. 9508 - 9511
Опубликована: Янв. 1, 2022
A
series
of
polycyclic
purinium
and
7-deazapurinium
salts
were
obtained
via
rhodaelectro-catalyzed
[4+2]
annulations
with
H
2
evolution.
Язык: Английский
Regiodivergent Synthesis of Brominated Pyridylthiophenes by Overriding the Inherent Substrate Bias
Synlett,
Год журнала:
2023,
Номер
35(04), С. 431 - 436
Опубликована: Июнь 5, 2023
Abstract
A
regiocontrolled
functionalization
of
a
pyridylthiophene
scaffold
was
accomplished.
Regioselectivity
for
deprotonation
the
switched
by
changing
reaction
conditions,
including
metal
amide
base
and
solvent.
Subsequently,
in
situ
transmetalation
halogen
dance
on
corresponding
organometallic
species
were
controlled
additives
temperature,
as
well
above
conditions.
This
method
successfully
enabled
synthesis
four
iodinated
constitutional
isomers
from
single
starting
material,
2-(5-bromo-2-thienyl)pyridine.
Язык: Английский
Photocatalyst-free visible-light-induced highly selective acylation of purine nucleosides at the C6 position
Chemical Communications,
Год журнала:
2023,
Номер
59(26), С. 3910 - 3913
Опубликована: Янв. 1, 2023
A
protocol
for
visible-light-induced
C-H
acylation
selectively
at
the
C6
position
of
purine
nucleosides
with
aldehydes
under
photocatalyst-free
conditions
was
established
herein.
This
allows
green,
mild,
and
efficient
functionalization
various
a
broad
range
alkyl
aryl
aldehydes.
Язык: Английский
Electrochemical Ruthenium‐Catalysed Directed C−H Functionalization of Arenes with Boron Reagents
Advanced Synthesis & Catalysis,
Год журнала:
2023,
Номер
366(4), С. 830 - 837
Опубликована: Дек. 19, 2023
Abstract
Ortho
‐directed
electrochemical
C−H
functionalization
of
aromatics
with
boron‐based
coupling
partners
has
been
achieved
under
ruthenium
catalysis
through
an
oxidatively
induced
reductive
elimination
mechanism.
Our
method
provides
a
single
set
conditions
delivering
arylation,
alkenylation
and
methylation,
yielding
ortho
‐functionalized
products
good
functional
group
tolerance,
including
examples
late‐stage
in
synthetically
useful
yields.
By
harnessing
electricity
as
‘green’
oxidant,
this
circumvents
the
need
for
stoichiometric
quantities
chemical
oxidants,
enhancing
our
sustainability
metrics.
Язык: Английский