RSC Advances, Год журнала: 2024, Номер 14(29), С. 20609 - 20645
Опубликована: Янв. 1, 2024
The photocatalytic field revolves around the utilization of photon energy to initiate various chemical reactions using non-adsorbing substrates, through processes such as single electron transfer, or atom transfer.
Язык: Английский
Процитировано
78Photoinduced, additive- and photosensitizer-free multi-component synthesis of naphthoselenazol-2-amines with air in water
Green Chemistry, Год журнала: 2023, Номер 25(20), С. 7983 - 7987
Опубликована: Янв. 1, 2023
An atom- and step-economical, efficient eco-friendly method for constructing naphthoselenazol-2-amines through a visible-light photocatalytic multi-component reaction under aqueous phase conditions is reported.
Язык: Английский
Процитировано
71Accelerated photochemical reactions at oil-water interface exploiting melting point depression
Science, Год журнала: 2024, Номер 383(6684), С. 750 - 756
Опубликована: Фев. 15, 2024
Water can accelerate a variety of organic reactions far beyond the rates observed in classical solvents. However, using pure water as solvent introduces solubility constraints that have limited applicability efficient photochemistry particular. We report here formation aggregates between pairs arenes, heteroarenes, enamines, or esters with different electron affinities an aqueous medium, leading to oil-water phase boundary through substrate melting point depression. The active hydrogen atoms reactants engage bonds water, thereby accelerating photochemical reactions. This methodology realizes appealingly simple conditions for coupling complex solid molecules, including drug molecules are poorly soluble water.
Язык: Английский
Процитировано
35Challenges and Future Perspectives in Photocatalysis: Conclusions from an Interdisciplinary Workshop
JACS Au, Год журнала: 2024, Номер 4(8), С. 2746 - 2766
Опубликована: Авг. 8, 2024
Photocatalysis is a versatile and rapidly developing field with applications spanning artificial photosynthesis, photo-biocatalysis, photoredox catalysis in solution or supramolecular structures, utilization of abundant metals organocatalysts, sustainable synthesis, plastic degradation. In this Perspective, we summarize conclusions from an interdisciplinary workshop young principal investigators held at the Lorentz Center Leiden March 2023. We explore how diverse fields within photocatalysis can benefit one another. delve into intricate interplay between these subdisciplines, by highlighting unique challenges opportunities presented each multidisciplinary approach drive innovation lead to solutions for future. Advanced collaboration knowledge exchange across domains further enhance potential photocatalysis. Artificial photosynthesis has become promising technology solar fuel generation, instance, via water splitting CO
Язык: Английский
Процитировано
18Overcoming the Oxygen Dilemma in Photoredox Catalysis: Near‐Infrared (NIR) Light‐Triggered Peroxynitrite Generation for Antibacterial Applications
Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(20)
Опубликована: Март 16, 2023
The peroxynitrite anion (ONOO- ) is closely associated with many diseases and the creation of ONOO- donors an essential means understanding its pathophysiological functions. However, it challenging to develop due difficulties in simultaneously producing highly reactive short-lived nitric oxide (NO) superoxide (O2 ⋅- ). Here, we report a novel strategy for constructing by combining near-infrared (NIR)-mediated type I photosensitization photoredox catalysis. key design using Nile blue analogue that can serve as both photosensitizer metal-free photocatalyst. Intriguingly, formation O2 via avoids oxygen interference instead activates nitrobenzofurazan-based NO oxygen-tolerant NIR simultaneous release leads release, showing antibacterial antibiofilm activities.
Язык: Английский
Процитировано
26Photochemistry in Medicinal Chemistry and Chemical Biology
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(6), С. 4322 - 4345
Опубликована: Март 8, 2024
Photochemistry has emerged as a transformative force in organic chemistry, significantly expanding the chemical space accessible for medicinal chemistry. Light-induced reactions enable efficient synthesis of intricate structures and have found applications throughout different stages drug discovery development processes. Moreover, photochemical techniques provide innovative solutions biology, allowing precise spatiotemporal activation targeted delivery. In this Perspective, we highlight already numerous remarkable even more promising future photochemistry chemistry biology.
Язык: Английский
Процитировано
13Artificial Photosynthases: Single-Chain Nanoparticles with Manifold Visible-Light Photocatalytic Activity for Challenging “in Water” Organic Reactions
Journal of the American Chemical Society, Год журнала: 2024, Номер 146(21), С. 14397 - 14403
Опубликована: Апрель 19, 2024
Photocatalyzed reactions of organic substances in aqueous media are challenging transformations, often because scarce solubility substrates and catalyst deactivation. Herein, we report single-chain nanoparticles, SCNPs, capable efficiently catalyzing four different "in water" by employing visible light as the only external energy source. Specifically, decorated a high-molecular-weight copolymer, poly(OEGMA300-r-AEMA), with iridium(III) cyclometalated complex pendants at varying content amounts. The isolated functionalized copolymers demonstrated self-assembly into noncovalent, amphiphilic SCNPs water, which enabled efficient visible-light photocatalysis two unprecedentedly reported namely, [2 + 2] photocycloaddition vinyl arenes α-arylation N-arylamines. Additionally, aerobic oxidation 9-substituted anthracenes β-sulfonylation α-methylstyrene were successfully carried out media. Hence, merging metal-mediated for fabrication artificial photoenzyme-like nano-objects─i.e., photosynthases (APS)─our work broadens possibilities performing transformations via photocatalysis.
Язык: Английский
Процитировано
11Radical Reactions in Organic Synthesis: Exploring in-, on-, and with-Water Methods
Molecules, Год журнала: 2024, Номер 29(3), С. 569 - 569
Опубликована: Янв. 23, 2024
Radical reactions in water or aqueous media are important for organic synthesis, realizing high-yielding processes under non-toxic and environmentally friendly conditions. This overview includes (i) a general introduction to chemistry media, (ii) synthetic approaches in, on, with as well heterogeneous phases, (iii) of carbon-centered radicals (or deuterium oxide) activated through coordination various Lewis acids, (iv) photocatalysis (v) applications bioinspired by naturally occurring processes. A wide range chemical strategies different experimental conditions have been reviewed that lead functional group translocation transformation reactions, leading the preparation complex molecules. These results reveal how solvent/medium/reagent radical has matured over last two decades, further discoveries anticipated near future.
Язык: Английский
Процитировано
9Applications of innovative synthetic strategies in anticancer drug Discovery: The Driving Force of new chemical reactions
Bioorganic & Medicinal Chemistry Letters, Год журнала: 2025, Номер 119, С. 130096 - 130096
Опубликована: Янв. 9, 2025
Язык: Английский
Процитировано
1Recent advances in photo-induced organic synthesis in water
Current Opinion in Green and Sustainable Chemistry, Год журнала: 2023, Номер 40, С. 100766 - 100766
Опубликована: Янв. 31, 2023
Язык: Английский
Процитировано
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